The etiological involvement of Helicobacter pylori on residual gastritis after gastrectomy

Nagahata, Yoshi; Azumi, Yoshinori; Numata, Norio; Saitoh, Yoichi

doi:10.1016/0016-5085(95)23354-7

Cited by 20 publications

(28 citation statements)

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“…However, the role of H. pylori has recently attracted attention, and many studies have documented a relationship between H. pylori infection and gastritis of the residual stomach [26,27,28,29,30,31]. Nagahata et al [28] reported that the histological gastritis score was significantly higher in patients with H. pylori infection than in those without it, and they concluded that H. pylori plays a role in gastritis after surgery. After H. pylori infection becomes established, the gastric epithelium and the glands in the lamina propria are damaged both by direct bacterial toxicity and by the effects of inflammatory cell infiltration.…”

Section: Discussionmentioning

confidence: 98%

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Hamaguchi

Ogawa

Katšube

et al. 2004

Langenbeck's Archives of Surgery

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Before H. pylori eradication, the mucosa of the residual stomach may be at high risk of carcinogenesis due to induction of mucosal damage and active gastritis by H. pylori. Such changes were almost completely normalized by eradication therapy, so the eradication of H. pylori may reduce the risk of H. pylori-associated carcinogenesis in patients who have undergone gastrectomy for early gastric cancer.

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Section: Discussionmentioning

confidence: 98%

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Hamaguchi

Ogawa

Katšube

et al. 2004

Langenbeck's Archives of Surgery

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“…After distal gastrectomy, the primary causes of remnant gastritis are H. pylori infection and bile reflux. 34 Distal gastrectomy increases the occurrence of biliary enterogastric reflux and potentially inhibits the growth of H. pylori in the stomach, 35 or even eradicates the organism. 36,37 These observations may explain the high rate of spontaneous H. pylori clearance in this study.…”

Section: Discussionmentioning

confidence: 99%

Randomised clinical trial: the effects ofHelicobacter pylorieradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer

Cho

Choi

Kook

et al. 2013

Aliment Pharmacol Ther

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“…Several studies have investigated the effect of partial gastrectomy on H. pylori infection [16][17][18]. Most of these were, however, studies of peptic ulcer patients, and to date there have been only a few small studies of H. pylori involvement after gastric cancer operation [19,20]. Surgery for gastric cancer differs in many ways from peptic ulcer surgery, in terms of, for example, the size of the GR, the complete devascularization and denervation because of lymph node dissection, the reconstruction method with less bile reflux, and the initial difference in background mucosa inside the stomach.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

et al. 2001

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therapy has improved, and a long postoperative life is usual in a majority of these patients with early-stage gastric carcinoma [1]. However, in these patients, the gastric remnant (GR) retains the mucosa that had been the background of the initial cancer, and the mucosa exists in nonphysiological circumstances. Thus, the possible development of a second primary cancer in the GR has been a problem. In practice, the incidence of a second primary cancer in the GR is considerably high. At our institute, second primary cancer in the GR was found in approximately 2% of the patients after curative resection of primary gastric carcinoma [2]. Thus, post-operative endoscopic surveillance has been emphasized to detect curable early-stage cancer in the GR [3].Our previous study demonstrated that the features of early-stage second primary cancer in the GR were somewhat different from those of ordinary primary gastric carcinoma; protruding lesions and intestinal type cancer were dominant, and the background mucosa of these lesions was often associated with atrophic gastritis or intestinal metaplasia [2,4]. Although the real cause of gastric carcinogenesis is not fully understood, several environmental factors, including infection with Helicobacter pylori, have been shown to be linked with gastric carcinogenesis [5]. Since Warren and Marshall [6] first isolated H. pylori from the stomachs of patients with gastritis, numerous studies have demonstrated the relationship between H. pylori infection and the development of gastric cancer [7][8][9][10]. Now, H. pylori is regarded as a definite carcinogen [11] and as a trigger for the sequence of carcinogenesis, because there is strong evidence for H. pylori infection as a cause of chronic atrophic gastritis and intestinal metaplasia, two possible precancerous lesions [9,10,[12][13][14]. Our previous observations on the background mucosa of early-stage carcinoma of the GR also indicated an intimate association between atrophic gastritis and intestinal-type gastric carcinoma [2]. Thus, involvement of H. pylori in carAbstract Background. The development of a second primary cancer in the gastric remnant after gastrectomy for early gastric carcinoma is a problem, and eradication of Helicobacter pylori after the operation has been recommended. However, to date, practical indications for H. pylori eradication after gastric cancer surgery have not yet been reported. Methods. We examined H. pylori infection in the gastric remnant after distal gastrectomy for primary gastric cancer. One hundred and nine patients who had had a gastrectomy were studied. Endoscopic findings and results from the urease test, bacteriologic assessment, serological test, and histopathological examination were analyzed. Results. Seventy-one patients (65.1%) were judged to be positive for H. pylori infection. The prevalence of H. pylori infection was found to be significantly decreased in older patients, patients in whom the operation had been performed a long time before examination, patients with symptoms, and pati...

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The etiological involvement of Helicobacter pylori on residual gastritis after gastrectomy

Cited by 20 publications

References 0 publications

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Does eradication of Helicobacter pylori reduce the risk of carcinogenesis in the residual stomach after gastrectomy for early gastric cancer?

Randomised clinical trial: the effects ofHelicobacter pylorieradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer

Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

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