Randomised clinical trial: the effects ofHelicobacter pylorieradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer

Abstract

SUMMARY BackgroundHelicobacter pylori eradication is recommended for early gastric cancer (GC) patients after resection.

Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis

“…The selected studies were published between 2000 and 2013. Four trials were conducted in China [3,7,9,18], 2 in Korea [10,19], 1 in Japan [6], and 1 in Colombia [1]. Duration of follow-up in each study ranged from 2 to 15 years.…”

“…Five trials chose two methods to confirm the infection while three trials used one. Participants in each study had a similar baseline of histology diagnosis, ranging from NAG to DYS, except that 3 studies included patients who had a history of GC and received endoscopic or surgical resection [6,10,19].…”

“…Among studies regarded metachronous GC as outcome, two of them defined GC as either noninvasive or invasive tumor corresponding to Vienna classification [6,10]. One used American Joint Committee on Cancer TNM classification system [19].…”

“…Five studies [1,3,4,9,18] chose the most advanced biopsy as the baseline diagnosis and two [17,19] made the diagnosis in different sites separately, while three studies did not describe the method explicitly [19]. Regarding the definition of progression of PL, two trials [1,4] compared the baseline and outcome histologic diagnoses based on the consecutive step of PL, two [9,17,19] applied a histological score comparison between baseline and outcome (e.g.…”

“…Regarding the definition of progression of PL, two trials [1,4] compared the baseline and outcome histologic diagnoses based on the consecutive step of PL, two [9,17,19] applied a histological score comparison between baseline and outcome (e.g. progression was defined as higher score at outcome compared with baseline), while four did not provide the relevant data.…”