The essential role of hippocampo-cortical connections in temporal coordination of spindles and ripples

Enhancement of hippocampal-thalamocortical temporal coordination during slow-frequency long-duration anterior thalamic spindles

“…The model consists of thalamocortical and CA1-CA3 neural networks with long-range bidirectional hippocampal-thalamocortical and cortico-thalamic projections. As we previously described (Ghorbani et al, 2012; Hashemi et al, 2019; Azimi et al, 2021), in this model the up and down states with high frequency activity during the up states are generated in recurrently connected cortical networks due to dendritic spike frequency adaptation. Similar to previous studies (Cona et al, 2014; Destexhe et al, 1996; Destexhe and Sejnowski, 2003; Hashemi et al, 2019) spindles are generated in a bursting recurrent thalamic network which in our model simply consists of one identical group of inhibitory neurons representing the thalamic reticular neurons and one identical group of thalamocortical neurons.…”

“…The neural mass hippocampal-thalamocortical model consists of two hippocampal networks representing CA1 and CA3 networks, one thalamic and two cortical networks. The networks were described in our previous papers (Ghorbani et al, 2012; Hashemi et al, 2019; Azimi et al, 2021). In short, each of cortical and hippocampal networks consists of one group of identical inhibitory (I) neurons (number of neurons: , CX represents the cortical network) and one group of identical excitatory (E) neurons (number of neurons: ).…”

“…The model consists of thalamocortical and CA1-CA3 neural networks with long-range bidirectional hippocampal-thalamocortical and cortico-thalamic projections. As we previously described (Ghorbani et al, 2012;Hashemi et al, 2019;Azimi et al, 2021), in this model the up and down states with high frequency activity during the up states are generated in recurrently . CC-BY 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.…”

“…The neural mass hippocampal-thalamocortical model consists of two hippocampal networks representing CA1 and CA3 networks, one thalamic and two cortical networks. The networks were described in our previous papers (Ghorbani et al, 2012;Hashemi et al, 2019;Azimi et al, 2021 = 1000, N e CA1 = 1000). The model is a firing rate model (Ghorbani et al, 2012;Hashemi et al, 2019) so that the firing rate (r) of hippocampal and cortical neurons is simply a sigmoid function of the membrane potential (…”

Single acoustic closed loop stimulation in mice to modulate hippocampo-thalamo-cortical activity and performance

“…Our results clearly show that the temporal organization of hippocampal activity and behavior are affected by sACLS phase underscoring a strong connection between intact hippocampal activity during NREM sleep and memory retention on this spatial task. Recent experimental and modelling research reveal increasingly complex neurophysiological interdependencies between cortical and hippocampal activity during NREM sleep (Wei et al 2020; Azimi et al 2021; Sanda et al 2021; Skelin et al 2021).…”