Progress on the hippocampal circuits and functions based on sharp wave ripples

Xie, Bing; Zhen, Zhi-Hang; Guo, Ouyang; Li, Heming; Guo, Meijun; Zhen, Junli

doi:10.1016/j.brainresbull.2023.110695

Cited by 1 publication

(1 citation statement)

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“…Hippocampal SWR, an eruption of hippocampal activity, represents an essential neuronal oscillatory phenomenon that is closely associated with the encoding of memories and the transfer of recently acquired memory traces to the neocortex for long-term storage (Xie et al, 2023 ). It is suggested that SWRs emerge as a result of synchronized activation of the CA1 region, driven by inputs from hippocampal CA3 pyramidal neurons (Buzsaki, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Zhang,

Guo,

et al. 2024

Front. Neurosci.

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IntroductionIn our study, we applied transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound stimulation within a static magnetic field, in the APP/PS1 mouse model of Alzheimer's disease (AD) to explore the feasibility of TMAS on improving AD related spatial memory deficits and abnormal neural oscillations.MethodsThe mice treated with TMAS once daily for 21 days. We recorded local field potential signals in the hippocampal CA1 region of the mice after TMAS treatment with in-vivo electrophysiology and evaluated the neural rehabilitative effect of TMAS with sharp-wave ripple (SWR), gamma oscillations during SWRs, and phase-amplitude coupling (PAC). The spatial memory function of the mice was examined by the Morris water maze (MWM) task.ResultsWe found that TMAS improved the performance of MWM related spatial cognitive functions compared with AD group. Furthermore, our results implied that TMAS alleviated abnormalities in hippocampal SWRs, increased slow gamma power during SWRs, and promoted theta-slow gamma phase-amplitude coupling. These findings suggest that TMAS could have a positive influence on spatial memory through the modulation of neural oscillations.DiscussionThis work emphasizes the potential of TMAS to serve as a non-invasive method for Alzheimer's disease rehabilitation and promote the application of TMAS for the treatment of more neurological and brain aging diseases in the future.

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Section: Discussionmentioning

confidence: 99%