The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing

Cavalcanti, Josenilda Malveira; Leal-Cardoso, José Henrique; Diniz, Lúcio Ricardo Leite; Portella, Viviane Gomes; Costa, Carolina Oliveira; Linard, Cybelle Façanha Barreto Medeiros; Alves, Karuza; Rocha, Maria Valdenir Abreu de Paula; Lima, Crystiane Calado; Cecatto, Vânia Marilande; Coelho‐de‐Souza, Andrelina Noronha

doi:10.1016/j.jep.2012.08.030

Cited by 58 publications

(19 citation statements)

References 30 publications

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“…We studied not only the combination of FEO with MUP, but also the combination of FEO main component – t A with MUP which, according to available data, improves cutaneous wound healing. This provides data on its oral LD 50 values between 1.8–5.0 g for mice, rats and guinea pigs [26, 27]. It can be concluded that antimicrobial activity of FEO compared with t A is determined by more than one particular component, and depends on the synergistic activities of different oil constituents.…”

Section: Discussionmentioning

confidence: 99%

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers

Kwiatkowski¹,

Pruss²,

Masiuk³

et al. 2019

pdia

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Introduction Staphylococcus aureus constitutes the most pathogenic species within the staphylococcal genus. Humans remain the major reservoirs of this pathogen which colonizes mostly anterior nares of healthy individuals. Aim To investigate the effect of fennel essential oil (FEO) and trans -anethole ( t A) on antibacterial activity of mupirocin (MUP) against S. aureus strains isolated from asymptomatic carriers. Material and methods The content of the FEO was analysed with use of the GC-MS method. The research done on 43 S. aureus isolates with different resistance patterns, obtained from nasal vestibule. Antibacterial activity of MUP in combination with FEO or t A was examined using the agar dilution method and E-test method. The data analysis was done with the Pearson’s χ 2 test. Results The chemical composition of FEO was consistent with the European Pharmacopoeia (EP) for the main constituent – t A (77.9%) according to the EP recommendations. Macrolide-lincosamide-streptogramin B resistance phenotype was prevalent among 39.5% of S. aureus isolates. FEO concentrations of 2.0% and 2.5% revealed antibacterial activity against 76.7% of isolates, whereas t A inhibited S. aureus growth at concentrations > 4.0%. The MIC values for MUP combined with FEO as well as for MUP combined with t A were < 0.064 µg/ml for 79.1% and 86.0% of S. aureus isolates, respectively. Conclusions Our experiment revealed FEO and t A influence on MUP effectiveness. The combination of MUP with FEO as well as MUP with t A are worth considering to implement in S. aureus eradication procedures. These findings will be useful in designing efficient antistaphylococcal agents which can limit the emergence of antibiotic resistance.

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Section: Discussionmentioning

confidence: 99%

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers

Kwiatkowski¹,

Pruss²,

Masiuk³

et al. 2019

pdia

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“…This new local anesthetic effect adds to the list of other pharmacological actions of estragole, such as antimicrobial (7), antioxidant (8), anti-edematogenic, and anti-inflammatory (13) effects, and places this substance as a candidate for therapeutic usefulness to treat ulcerations (infected or not), for example, and similar illnesses. In addition to these activities, one can consider that anethole, with a molecular structure very similar to estragole, has been documented to have procicatrizing activity (36). This prospect also increases when one takes into consideration recent studies showing that long-lasting per os administration of 37.5 mg/kg estragole showed no toxic effects (37), suggesting that extracts having estragole as the principal constituent, like fennel seed extract, have anticancer (for certain types of cancer) and antioxidant activities, and radical scavenging potential (38).…”

Section: Discussionmentioning

confidence: 99%

Estragole blocks neuronal excitability by direct inhibition of Na+ channels

Silva‐Alves

Ferreira-da-Silva

Peixoto‐Neves

et al. 2013

Braz J Med Biol Res

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Estragole is a volatile terpenoid, which occurs naturally as a constituent of the essential oils of many plants. It has several pharmacological and biological activities. The objective of the present study was to investigate the mechanism of action of estragole on neuronal excitability. Intact and dissociated dorsal root ganglion neurons of rats were used to record action potential and Na+ currents with intracellular and patch-clamp techniques, respectively. Estragole blocked the generation of action potentials in cells with or without inflexions on their descendant (repolarization) phase (Ninf and N0 neurons, respectively) in a concentration-dependent manner. The resting potentials and input resistances of Ninf and N0 cells were not altered by estragole (2, 4, and 6 mM). Estragole also inhibited total Na+ current and tetrodotoxin-resistant Na+ current in a concentration-dependent manner (IC50 of 3.2 and 3.6 mM, respectively). Kinetic analysis of Na+ current in the presence of 4 mM estragole showed a statistically significant reduction of fast and slow inactivation time constants, indicating an acceleration of the inactivation process. These data demonstrate that estragole blocks neuronal excitability by direct inhibition of Na+ channel conductance activation. This action of estragole is likely to be relevant to the understanding of the mechanisms of several pharmacological effects of this substance.

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“…Members of the genus have been used in traditional medicine to treat a wide range of disorders, including malaria, inflammation, diabetes and cancer [2]. The biological properties of various Croton species have been investigated in laboratory studies involving murine models [3,4,5,6,7,8,9,10]. The chemical composition of Croton is somewhat diverse, although alkaloids [11,12], diterpenoids [13,14] and volatile oils comprising mono- and sesquiterpenoids [15,16,17,18], have been commonly reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Croton rhamnifolioides Essential Oil on Aedes aegypti Oviposition, Larval Toxicity and Trypsin Activity

et al. 2014

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Although numerous reports are available concerning the larvicidal potential of essential oils, very few investigations have focused on their mechanisms of action. In the present study, we have investigated the chemical composition of the leaf oil of Croton rhamnifolioides during storage and its effects on oviposition and survival of larvae of the dengue fever mosquito Aedes aegypti. In addition, we have established a possible mechanism of action for the larvicidal activity of the essential oil. GC-MS analyses revealed marked differences in the composition of oil that had been freshly isolated and that of a sample that had been stored in a sealed amber-glass vial under refrigeration for three years. However, both fresh and stored oil exhibited substantial larvicidal activities with LC50 values of 122.35 and 89.03 ppm, respectively, and oviposition deterrent effects against gravid females at concentrations of 50 and 100 µg·mL . These results demonstrate that the larvicidal effect of the essential oil was unchanged during three years of storage even though its chemical composition altered. Hence, the essential oil could be used in the preparation of commercial products. In addition, we observed that the trypsin-like activity of mosquito larvae was OPEN ACCESSMolecules 2014, 19 16574 inhibited in vitro by the essential oil of C. rhamnifolioides, suggesting that the larvicidal effect may be associated with inhibition of this enzyme.

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The essential oil of Croton zehntneri and trans-anethole improves cutaneous wound healing

Abstract: Our data indicate that EOCz exerts significant wound healing activity, demonstrating its relevant therapeutic potential.

Cited by 58 publications

References 30 publications

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers

Estragole blocks neuronal excitability by direct inhibition of Na+ channels

Effects of Croton rhamnifolioides Essential Oil on Aedes aegypti Oviposition, Larval Toxicity and Trypsin Activity

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