The Essential Oil from Angelica gigas NAKAI Suppresses Nicotine Sensitization

Zhao, Rongjie; Koo, Byung Soo; Kim, Geun Woo; Jang, Eun Young; Lee, Jong Rok; Kim, Mi Ryeo; Kim, Sang Chan; Kwon, Young Kyu; Kim, Kwang Joong; Huh, Tae Lin; Kim, Dae Hyun; Shim, Insop; Yang, Chae Ha

doi:10.1248/bpb.28.2323

Cited by 16 publications

(14 citation statements)

References 26 publications

(23 reference statements)

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“…Locomotor activity was measured as described previously (Jeon et al, 2008; Zhao et al, 2005). Locomotor activity was monitored and measured with a video tracking system (Ethovision, Nodus Information Technology BV, Wageningen, Netherlands) that provided automatic measures of traveled distance (m).…”

Section: Methodsmentioning

confidence: 99%

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

et al. 2016

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Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. Methamphetamine-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are implicated in behavior changes and DA release in the nucleus accumbens (NAc) following cocaine administration. The aim of this study was to evaluate the involvement of ROS in METH-induced locomotor activity, self-administration, and enhancement of DA release in the NAc. Systemic administration of a non-specific ROS scavenger, N-tert-butyl-α-phenylnitrone (PBN; 0, 50 and 75 mg/kg, IP), or a superoxide selective scavenger, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL; 0, 50 and 100 mg/kg, IP), attenuated METH-induced locomotor activity without affecting generalized behavior in METH naïve rats. PBN and TEMPOL significantly attenuated METH self-administration without affecting food intake. Increased oxidative stress was found in neurons, but not astrocytes, microglia or oligodendrocytes, in the NAc of METH self-administering rats. In addition, TEMPOL significantly decreased METH enhancement of DA release in the NAc. Taken together, these results suggest that enhancement of ROS in the NAc contributes to the reinforcing effect of METH.

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Section: Methodsmentioning

confidence: 99%

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

et al. 2016

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“…In addition, the nicotinic acetylcholine receptor was also demonstrated to be an important mediator of the pharmacologic action of Angelica gigas Naki (Zhao et al, 2005). Although direct evidence of the anti-inflammatory effect of decursinol and its action on COX activity are not currently apparent, it is probable that the antinociceptive effect of decursinol is involved with several neurotransmitters that mediate the analgesic effect of NSAIDs at the supraspinal or spinal level.…”

Section: Introductionmentioning

confidence: 99%

The analgesic effect of decursinol

Seo

Kwon²,

Park

et al. 2009

Arch. Pharm. Res.

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Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet. In this study, we characterized the possible interaction between decursinol and aspirin or acetaminophen in the writhing test. The antinociceptive effects of decursinol were observed at an orally-administered dose of 50 mg/kg but not at 25 or 10 mg/kg. In addition, the analgesic effects of aspirin (ASA) and acetaminophen (APAP) were shown at an orally-administered dose of 200 mg/kg but not at 50 or 100 mg/kg. We examined the effects of decursinol on the ASA or APAP at sub-analgesic doses. Although the co-administration of decursinol and ASA did not show any differences at doses of 10 or 25 mg/kg and 50 or 100 mg/kg, respectively, synergistic effects between decursinol and APAP were observed in the group of decursinol (25 mg/kg) and APAP (100 mg/kg) co-administration. These results indicated that the analgesic effect of decursinol might be involved in supraspinal cyclooxygenase regulation that might be overlapped with APAP-induced analgesic mechanisms rather than systemic or peripheral prostaglandin modulation.

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“…This herb been used traditionally for the treatment of psychosomatic diseases such as excess stress, anxiety, depression, pain and insomnia [1011121314]. So far, recent studies have been shown that the essential oil components of AGR exhibited anxiolytic-like effects in rodents tests [15].…”

Section: Introductionmentioning

confidence: 99%

Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviorsviathe activation of GABA_A-ergic systems in rodents

Woo

Kang

et al. 2017

Korean J Physiol Pharmacol

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Angelicae Gigantis Radix (AGR, Angelica gigas) has been used for a long time as a traditional folk medicine in Korea and oriental countries. Decursinol angelate (DCA) is structurally isomeric decursin, one of the major components of AGR. This study was performed to confirm whether DCA augments pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in animals. Oral administration of DCA (10, 25 and 50 mg/kg) markedly suppressed spontaneous locomotor activity. DCA also prolonged sleeping time, and decreased the sleep latency by pentobarbital (42 mg/kg), in a dose-dependent manner, similar to muscimol, both at the hypnotic (42 mg/kg) and sub-hypnotic (28 mg/kg) dosages. Especially, DCA increased the number of sleeping animals in the sub-hypnotic dosage. DCA (50 mg/kg, p.o.) itself modulated sleep architectures; DCA reduced the counts of sleep/wake cycles. At the same time, DCA increased total sleep time, but not non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. In the molecular experiments. DCA (0.001, 0.01 and 0.1 µg/ml) increased intracellular Cl- influx level in hypothalamic primary cultured neuronal cells of rats. In addition, DCA increased the protein expression of glutamic acid decarboxylase (GAD65/67) and GABAA receptors subtypes. Taken together, these results suggest that DCA potentiates pentobarbital-induced sleeping behaviors through the activation of GABAA-ergic systems, and can be useful in the treatment of insomnia.

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The Essential Oil from Angelica gigas NAKAI Suppresses Nicotine Sensitization

Cited by 16 publications

References 26 publications

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

The analgesic effect of decursinol

Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviorsviathe activation of GABA_A-ergic systems in rodents

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The Essential Oil from Angelica gigas NAKAI Suppresses Nicotine Sensitization

Cited by 16 publications

References 26 publications

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

The role of reactive oxygen species in methamphetamine self-administration and dopamine release in the nucleus accumbens

The analgesic effect of decursinol

Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviorsviathe activation of GABAA-ergic systems in rodents

Contact Info

Product

Resources

About

Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviorsviathe activation of GABA_A-ergic systems in rodents