The analgesic effect of decursinol

Abstract

Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet. In this study, we characterized the possible interaction between decursinol and aspirin or acetaminophen in the writhing test. The antinociceptive effects of decursinol were observed at an orally-administered dose of 50 mg/kg but not at 25 or 10 mg/kg. In addition, the analgesic effects of aspirin (ASA) and acetaminophen (APAP) were shown at an orally-administered dose of 200 mg/kg but not at 50 or 100 mg/kg. We examined the effects of decursinol on the ASA or APAP at sub-analgesic doses. Although the co-administration of decursinol and ASA did not show any differences at doses of 10 or 25 mg/kg and 50 or 100 mg/kg, respectively, synergistic effects between decursinol and APAP were observed in the group of decursinol (25 mg/kg) and APAP (100 mg/kg) co-administration. These results indicated that the analgesic effect of decursinol might be involved in supraspinal cyclooxygenase regulation that might be overlapped with APAP-induced analgesic mechanisms rather than systemic or peripheral prostaglandin modulation.

Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)

“…S. odoratissima tannins could presented a similar activity. The others secondary metabolites, presents in HMF, have been report as antinociceptive and anti-inflammatory compounds (Corrêa et al, 2008;Coutinho et al, 2009;Melo et al, 2009;Seo et al, 2009), this fact could explain the better effect of HMF in PLA2 activity assay.…”

Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviorsviathe activation of GABAA-ergic systems in rodents

“…DCA is one of major components of AGR, have been reported as anti-amnesic [32], analgesic, anti-cancer, anti-bacterial, neuroprotective and protein kinase C (PKC) activating activities from in vivo and in vitro experiment [3334353637]. From these experiments, oral administration of DCA suppressed spontaneous locomotor activity.…”

Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway

“…Extracts of Angelica gigas and decursinol exhibited analgesic and anti-nociceptive activities in cytokine and acetic acid-induced pain models [14,40]. The pain induced by cytokines or acetic acid results from inflammatory responses related to NO and PG.…”

“…As described in previous reports [9,25,40], we analyzed the ingredients in EAG with a focus on coumarin derivatives including decursin and decursinol angelate using an HPLC device (Waters, USA). Chromatographic separation was achieved using ChemcoPak Chemcobond 5-ODS-H column (3 µm, 4.6 × 150 mm internal diameter), and 2996 PDA photodiode detection was employed at a wavelength of 210 nm.…”

“…Next, decursinol from Angelica gigas was found to possess analgesic and anti-nociceptive activities [9,40]. More recently, decursin was shown to inhibit the induction of inflammatory mediators from lipopolysaccharide (LPS)-stimulated macrophages [25].…”