The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI)

Abdullahi, Mohamed; Annibale, Bruno; Capoccia, Danila; Tari, Roberto; Lahner, Edith; Osborn, John; Leonetti, Frida; Severi, Carola

doi:10.1007/s11695-008-9477-z

Cited by 93 publications

(61 citation statements)

References 37 publications

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“…By contrast, lower basal metabolic index (BMI) patients (especially Asian) will have better outcomes [10]. Smoking is another risk factor for failure of therapy.…”

Section: Risk Factorsmentioning

confidence: 99%

Helicobacter pylori infection: A recent approach to diagnosis and management

Rana¹,

Wang²,

Li³

et al. 2017

J. Biomed

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Helicobacter pylori infection is the most common infection worldwide and is associated with simple dyspepsia, heartburn and peptic ulcer diseases, most commonly leading to upper gastrointestinal bleeding and, ultimately, to the severe complication of gastric malignancy. Ninety percent of duodenal ulcers and 70% of gastric ulcers are associated with helicobacter pylori infections. Noninvasive methods, such as the urea breath test (UBT-13C or 14C) and fecal antigen test (FAT), have high sensitivity and specificity for the diagnosis of H. pylori. However, 4-6 weeks of anti-secretary drugs (proton pump inhibitor) prior to testing can lead to false negative results. Invasive methods have benefits over noninvasive methods in the case of peptic ulcer diseases by taking samples for culture to determine their sensitivities and to stage disease progression to malignant transformation. Initially, standard triple regimen was the choice for treatment worldwide. However, high antibiotic resistances in various geographical regions have recently made standard quadruple therapy (bismuth-based) the preferred treatment. Recent studies have shown the promising benefits of 10-14 days of sequential and concomitant quadruple therapies as the first line option in high drug resistance areas, in cases of multidrug resistance or in prior treatment failure cases. Levofloxacin-based triple therapy, furazolidone-based regimens, and recent hybrid or rescue therapies are also beneficial towards the eradication of H. pylori infection as a second or third line therapy. Additionally, the use of probiotics and phytomedicines improve eradication rates when used with triple or quadruple therapies.

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“…By contrast, lower basal metabolic index (BMI) patients (especially Asian) will have better outcomes [10]. Smoking is another risk factor for failure of therapy.…”

Section: Risk Factorsmentioning

confidence: 99%

Helicobacter pylori infection: A recent approach to diagnosis and management

Rana¹,

Wang²,

Li³

et al. 2017

J. Biomed

View full text Add to dashboard Cite

show abstract

“…The urea breath test uses the fact that H. pylori yields urease, an enzyme that metabolizes urea into ammonia and carbon dioxide (CO 2 ). For this test, patients swallow a tablet that contains a small amount of 13C-labeled urea (Abdullahi et al 2008;Fleming et al 2009). 13C is a nonradioactive form of carbon that is slightly heavier than normal carbon.…”

Section: Noninvasive Testsmentioning

confidence: 99%

Biomarkers and diagnostic tools for detection of Helicobacter pylori

Khalilpour

Kazemzadeh-Narbat

Tamayol

et al. 2016

Appl Microbiol Biotechnol

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Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms.

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“…Abdullahi et al [6] compared 40 overweight/obese patients with 41 normal weight patients in a non-diabetic cohort and suggested that overweight/obese nondiabetic patients showed a significantly lower rate of eradication rate of H. pylori infection than controls, and that BMI and corpus-predominant gastritis appear to be independent risk factors for eradication failure, concluding that alternative treatment regimens with higher dose and/or longer duration may be necessary in obese/overweight patients to achieve a higher eradication rate. However, in our cohort, it was not possible to find differences in eradication rates among the various subgroups according to the BMI, neither dividing patients as obese and nonobese (71 vs. 42 patients), regardless of the duration of treatment.…”

Section: The Impact Of Bmi On H Pylori Eradication Is Debatablementioning

confidence: 99%

“…In the last two decades, several studies have shown strong evidence of some of these factors related to the host that negatively influence the eradication rates, especially polymorphisms in the genes CYP2C19, MDR1, and IL-1, [1][2][3] low compliance, [4] and hypersecretion of hydrochloric acid. [5] However, the evidence is scarce for other factors, particularly the impact biotype, [6] smoking, [7] diabetes mellitus (DM), [8] and previous treatment failure. In particular, it is unknown whether the body mass index (BMI) influences in a clinically significant way the phar macokinetics and/or pharmacodynamics of the drugs involved in eradication (in particular, the proton pump inhibitors and antibiotics).…”

Section: Introductionmentioning

confidence: 99%

Loose ends in the eradication of Helicobacter pylori infection

Peixoto

Silva

Gaspar

et al. 2016

Journal of Translational Internal Medicine

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The eradication of Helicobacter pylori is essential for prevention and treatment of various conditions associated with this infection. However, its effectiveness is limited and influenced by factors linked to the bacteria and the host. In particular, influence of the biotype, smoking, diabetes mellitus, and previous treatment failure in eradication is understudied. Our center proposed to evaluate these aspects in a real life cohort by applying a questionnaire with demographic and lifestyle variables in patients who consecutively underwent urease breath test after the eradication therapy.

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The Eradication of Helicobacter pylori is Affected by Body Mass Index (BMI)

Abstract: Overweight/obese nondiabetic patients showed a significantly lower rate of eradication rate of H. pylori infection than controls. BMI and corpus-predominant gastritis appear to be independent risk factors for eradication failure.

Cited by 93 publications

References 37 publications

Helicobacter pylori infection: A recent approach to diagnosis and management

Helicobacter pylori infection: A recent approach to diagnosis and management

Biomarkers and diagnostic tools for detection of Helicobacter pylori

Loose ends in the eradication of Helicobacter pylori infection

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