Loose ends in the eradication of <i>Helicobacter pylori</i> infection

Peixoto, Armando; Silva, Marco; Gaspar, Rui; Morais, Rui; Ramalho, Rosa; Macedo, Guilherme; Santos-Antunes, João

doi:10.1515/jtim-2016-0038

Cited by 2 publications

(3 citation statements)

References 9 publications

(12 reference statements)

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“…In all studies included, 11 prospective studies compared the H. pylori eradication rate in diabetes and non‐diabetes 29‐39 . Eleven retrospective studies compared the proportion of diabetes and other clinic factors (age, gender, smoking, drinking, overweight, peptic ulcer disease, blood pressure, and history of NSAIDS) in groups failed and succeed in H. pylori eradication 40‐50 . Four studies further compared the level of HbA1c in diabetics failed and succeed in H. pylori eradication 30,35,37,49 .…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

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Background and Aims Previous studies have revealed the association between Helicobacter pylori (H. pylori) and diabetes mellitus, but conflicts still exist. The present study tried to investigate the underlying link between these two diseases by making comprehensive analyses of the impact of diabetes on H. pylori eradication and the influence of H. pylori eradication on diabetes. Methods We systematically searched relevant studies from PubMed, Cochrane Library, Web of Science, and Embase updated to April 23, 2020. Studies examining the association between H. pylori eradication and diabetes were included. Pooled odds ratio (OR) and weighted mean differences (WMD) were calculated for different results. Results Among the 2125 retrieved studies, 36 studies were included. Patients with type 2 diabetes mellitus (T2DM) have higher risk of H. pylori eradication failure than the non‐diabetic one (OR = 2.59, 95% CI 1.82–3.70). Body mass index (BMI) was identified as a major factor affecting the efficacy of H. pylori eradication in diabetics, and better glycemic control was also found in eradication succeed patients (WMD: 0.51, 95% CI 0.20–0.81). Moreover, after eradication of H. pylori, improvement of HbA1c was proved (WMD = −0.33, 95% CI −0.65 to −0.02) in T2DM. Conclusion A higher risk of H. pylori eradication failure in T2DM was confirmed, and it was associated with BMI and glycemic control. Moreover, we also provided evidence that H. pylori eradication could improve glycemic control in patients with T2DM, which indirectly reflect the interaction between H. pylori and the diabetes.

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Section: Resultsmentioning

confidence: 99%

“…Twenty‐two studies were included in these part of meta‐analysis, included 11 case‐control studies 29‐39 and 11 cohort studies 40‐50 enrolling in 5466 participants. Among them, three studies were split into two part to be included, 33,36,48 according to their group design.…”

Section: Resultsmentioning

confidence: 99%

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

et al. 2021

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“…In another study, significantly successful eradication of H. pylori infection was observed in 55.0% of the overweight/obese patients and 85.4% in normal adult ( 17 ). While in a study, overweight/obese non-diabetic patients found a significantly lower rate of H. pylori eradication than control group ( 18 ). Therefore, over-weight may be independent risk factors for H. pylori eradication failure ( 17 ).…”

Section: Introductionmentioning

confidence: 94%

The Effect of Helicobacter pylori Infection on Overweight: A Systematic Review and Meta-Analysis

Kamarehei¹,

Mohammadi²

2022

ijph

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Background: The association between Helicobacter pylori infection and overweight, as one of the most common health issues, remains controversial. In this study, we systematically reviewed the effect of H. pylori infection and overweight to get a reliable answer. Methods: We used the Preferred Reporting Items for the Systematic Review and Meta-Analysis statement. We searched the association between H. pylori and overweight infection in international databases including Medline, Web of knowledge and Scopus, without any limitations of language, publication type, and publication status in search step of this systematic review from 2000 to 2020. We surveyed the title, abstract and full text of each research studies, and we used Newcastle-Ottawa quality for assessing the quality of each paper. A random effects model was used to calculate the pooled odd ratio with 95% confidence intervals. Results: Fifteen papers were eligible for this review. The selected studies reported different Odd Ratio between overweight and H. pyloriinfection but Odds Ratio (95% confidence interval) in our systematic and meta-analysis study was estimated at 1.42 (95%CI; 1.12, 1.81) and it was statistically significant (P: 0.003). Conclusion: H. pylori infection is significantly associated with overweight, therefore, the eradication of H. pylori infection is suggested because this infectious might be resulted in overweight.

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Loose ends in the eradication of Helicobacter pylori infection

Cited by 2 publications

References 9 publications

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

The efficacy of Helicobacter pylori eradication in diabetics and its effect on glycemic control: A systematic review and meta‐analysis

The Effect of Helicobacter pylori Infection on Overweight: A Systematic Review and Meta-Analysis

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