The Epstein-Barr virus and nasopharyngeal carcinoma

Tarr, Kathleen L.; Glaser, Ronald

doi:10.1016/0882-4010(89)90107-1

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…An association between Epstein-Barr virus (EBV) and a number of malignancies, such as endemic Burkitt's lymphoma (BL) [ 13, nasopharyngeal carcinoma (NPC) [2] and immunocompromise-associated non-Hodgkin's lymphoma (NHL) [3], has long been recognized. In fact, an association between EBV and Hodgkin's disease (HD) is also being increasingly accepted.…”

Section: Introductionmentioning

confidence: 99%

Epstein‐barr virus (EBV) latent membrane protein (LMP) in tumor cells of Hodgkin's disease in pediatric patients

Preciado

Matteo

Diez

et al. 1995

Med. Pediatr. Oncol.

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Twenty-nine out of 31 consecutive pediatric patients with Hodgkin's disease treated at our hospital from 1988 to 1992 were studied. The selection criterion was the availability of sufficient formalin-fixed, paraffin-embedded tissue for analysis. Patient age ranged from 3 to 15 years with a median age of 7 years. Lymph node biopsies were examined for the presence of Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP) in malignant cells by peroxidase immunolabeling. LMP positivity was present in 10/15 (67%) of mixed cellularity, 1/6 (17%) of lymphocyte predominance, 0/7 (0%) of nodular sclerosis, and 1/1 (100%) of lymphocyte depletion. Positive cases by age range were: 10/12 (83%) for 3-6 years and 2/17 (11%) for 7-15 years. The association between EBV and Hodgkin's disease in children appeared to be more frequent in patients with mixed cellularity and those in the 3-6 age range, through examples of EBV-positive tumors were found in other histologic subtypes, stages and ages. Findings indicate that Hodgkin's disease in children is at least as strongly linked to EBV as in adults. Furthermore, we suggest that the EBV is associated with a subgroup of patients which can be defined on the basis of the age at diagnosis.

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Section: Introductionmentioning

confidence: 99%

Epstein‐barr virus (EBV) latent membrane protein (LMP) in tumor cells of Hodgkin's disease in pediatric patients

Preciado

Matteo

Diez

et al. 1995

Med. Pediatr. Oncol.

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“…The most prevalent malignant nasopharyngeal tumour is the WHO type 3 nasopharyngeal carcinoma. This is an undifferentiated type of tumour also known as lymphoepithelioma or Shminke's tumour (Tarr and Glaser, 1989). The tumour usually infiltrates submucosally and therefore the mucosal lining may appear to be normal to the examining clinician.…”

Section: Introductionmentioning

confidence: 99%

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Feinmesser

Freeman

et al. 1992

J. Laryngol. Otol.

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Detection of nasopharyngeal carcinoma primaries in patients presenting with neck node metastases may sometimes demand considerable efforts. By using the ‘ in situ hybridization’ technique, wemanage to identify the Epstein-Barr virus in neck metastases secondary to nasopharyngeal carcinomas. We propose that such identification in neck node metastases where the primary lesion is unknown indicates a nasopharyngeal primary.

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Expression of the epstein‐barr virus genome in a nasopharyngeal carcinoma epithelial tumor cell line

Zhang

Yao

Zhu

et al. 1990

Intl Journal of Cancer

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An epithelial tumor cell line was recently established from a biopsy specimen of a nasopharyngeal carcinoma (NPC), and designated HONE-I. Uncloned (parental) HONE-I and HONE-I clone (C)-40 cells were found to contain latent Epstein-Barr virus (EBV). Expression of the latent EBV genome in HONE-I C-40 cells has been examined. It was possible to detect a small percentage of cells spontaneously synthesizing EBV early antigen (EA) and virus capsid antigen (VCA) by immunofluorescence (IF). In addition, the EBV nuclear antigens (EBNA-I and EBNA-2), as well as the EBV latent membrane protein (LMP) were detected in the HONE-I cells. Attempts were made to induce the latent EBV genome in these cells with iododeoxyuridine (IUdR). We observed a significant increase in the number of EA/VCA-positive cells, an increase in EBV DNA, the synthesis of virus particles, and the rescue of infectious virus after treatment of HONE-I C-40 cells with IUdR. The HONE-I C-40 cells should facilitate studies of the expression and regulation of the EBV genome in NPC epithelial tumor cells, which have not previously been available.

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The Epstein-Barr virus and nasopharyngeal carcinoma

Cited by 6 publications

References 29 publications

Epstein‐barr virus (EBV) latent membrane protein (LMP) in tumor cells of Hodgkin's disease in pediatric patients

Epstein‐barr virus (EBV) latent membrane protein (LMP) in tumor cells of Hodgkin's disease in pediatric patients

Detection of occult nasopharyngeal primary tumours by means of in situ hybridization

Expression of the epstein‐barr virus genome in a nasopharyngeal carcinoma epithelial tumor cell line

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