The ‘EpiEnlist’ project: a dermo‐epidemiologic study on a representative sample of young Italian males. Prevalence of selected pigmentary lesions

Ingordo, Vito; Gentile, C; Iannazzone, SS; Cusano, Francesco; Naldi, Luigi

doi:10.1111/j.1468-3083.2007.02205.x

Cited by 38 publications

(37 citation statements)

References 45 publications

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“…Similarly to the results of this study, segmental vitiligo showed a low frequency of 5%. 9 Vtiligo affecting less than 25% of the body surface area was more prevalent in another study .However, there was a higher prevalence of vitiligo involving more than 50% of the body surface area in this study as compared with results from previous studies, where this frequency occurred in 5% and 7% of the cases. 11.21 The higher frequency of the universal type in this study may be due to the fact the study population was sought in a referral center of Dermatology, thereby attracting more severe cases of the disease.…”

Section: Discussioncontrasting

confidence: 55%

“…These percentage, compared to those in the literature, which ranged from 3.4% to 25.6%, is higher. 9,11,12,13,24 Antibodies in patients without vitiligo ranged from 13.9% for women to 2.8% for men 19 . Autoimmune diseases mostly associated with vitiligo were pernicious anemia, ranging from 1.8% to 2.3%, and rheumatoid arthritis, varying from 0.38% to 14%, which are higher than the rates found in the study population.…”

Section: Discussionmentioning

confidence: 99%

“…7 The site of onset and distribution of lesions differ according to age and region of the study population, but the most affected sites are, respectively, the head, limbs and trunk; the less affected sites are mucous membranes. 8,9 This pigmentation disorder follows a suggested classification because not all cases behave in the same way. The classification is based on the distribution and size of the depigmented area.…”

Section: Introductionmentioning

confidence: 99%

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Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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BACKGROUND: Vitiligo is considered the most frequent acquired hypomelanosis. Although its pathogenesis is uncertain, it is believed that autoimmune etiology is the most plausible. This theory is based on the coexistence of vitiligo with autoimmune diseases. Objectives: To describe the epidemiological profile of vitiligo patients and to estimate the prevalence of the association of vitiligo with autoimmune thyroid diseases. Methods: A cross-sectional study was conducted through analysis of the medical records of patients diagnosed with vitiligo in the AME-UNISUL Outpatient Clinic of Dermatology and at HU-UFSC. The clinical and laboratorial characteristics of these patients were assessed. Results: 85 medical records were evaluated; 56 patients were female, with a mean age of 37.14 years and mean onset age of 25.25 years. Vitiligo vulgaris occurred in 70.6%. Autoimmune thyroid diseases were found in 22.4%. Other autoimmune diseases were identified in 5.9%. Patients with positive thyroid autoantibodies showed a probability of extension of vitiligo greater than 25%. There was no statistical difference with regard to the clinical characteristics of vitiligo in patients with or without autoimmune thyroiditis with hormonal change. Conclusion: The findings of this study are similar to those obtained by other authors, showing that autoimmune thyroid diseases are more common in patients with vitiligo. Keywords: Autoimmunity; Thyroid diseases; Vitiligo Resumo: FUNDAMENTO: O vitiligo é considerado a hipomelanose adquirida mais frequente. Apesar de sua etiopatogenia ser incerta, acredita-se que a etiologia autoimune seja a mais plausível, teoria que se fundamenta na concomitância de vitiligo com doenças autoimunes. OBJETIVOS: Traçar o perfil epidemiológico dos pacientes com vitiligo e estimar a prevalência da associação de vitiligo com doenças autoimunes da tireoide. MÉTODOS: Efetuou-se um estudo transversal, analisando-se prontuários dos pacientes com diagnóstico de vitiligo atendidos no Ambulatório de Dermatologia AME-Unisul e do HU-UFSC. Avaliaram-se as características clínicas e laboratoriais desses pacientes. RESULTADOS: Foram avaliados 85 prontuários, sendo 56 do sexo feminino, com idade média de 37,14 anos e idade média de início de 25,25 anos. O vitiligo vulgar ocorreu em 70,6% dos casos. As doenças autoimunes da tireoide foram encontradas em 22,4% dos casos. Outras doenças autoimunes foram identificadas em 5,9% dos casos. Os pacientes com anticorpos antitireoidianos positivos revelaram uma probabilidade elevada de extensão do vitiligo maior que 25%. Não houve diferença estatística quanto às características clínicas do vitiligo em portadores ou não de tireoidite autoimune com alteração hormonal. CONCLUSÃO: Os resultados deste estudo são similares aos de outros autores, mostrando que as doenças autoimunes da tireoide são mais frequentes nos pacientes com vitiligo.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Nunes

Esser

2011

An. Bras. Dermatol.

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“…10 The most common type of vitiligo was vitiligo vulgaris (51%), similar to other studies, followed by acrofacial vitiligo (39%). 9,11,12 In children, focal vitiligo was found to be the most common type. 13 This is probably due to seeking early medical treatment, immediately after the appearance of the first vitiligo lesion in children.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

Jishna¹,

Binitha²,

Latheef³

et al. 2017

Int J Res Dermatol

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Background: Vitiligo is associated with various autoimmune diseases, including autoimmune thyroid disease. The objectives of the present study was to determine the prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in patients with vitiligo, and to compare the clinical profile of anti-thyroid peroxidase positive and anti-thyroid peroxidase negative patients.Methods: A cross-sectional comparative study was conducted in 100 patients with vitiligo and 100 controls. After dermatologic and systemic evaluation, serum thyroid hormones and anti-thyroid peroxidase antibody levels were measured in all the subjects.Results: Thyroid dysfunction was more common in the vitiligo group (27%) than in the controls. Serum thyroid stimulating hormone abnormalities were more common in the vitiligo group (27%) than in the controls (6%). The most common thyroid dysfunction was subclinical hypothyroidism. Anti-thyroid peroxidase antibody positivity was higher in the vitiligo group (36%) when compared to the controls (24%), and the most common type of vitiligo was vitiligo vulgaris (18%) in this group. Thyroid dysfunction and anti-thyroid peroxidase positivity were more common in women (58%) when compared to men (42%). There was a significantly higher prevalence of other autoimmune diseases in the vitiligo group (20%) compared to the controls (6%). Conclusions: This study shows a significant association between vitiligo and thyroid dysfunction, anti-thyroid peroxidase antibodies and other autoimmune diseases. We recommend that thyroid evaluation and regular follow-up should be done in patients with vitiligo for prompt detection of thyroid dysfunction.

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“…The study subjects were enrolled from 23,354 young men assessed at the Draft Council’s Medical Unit of the Italian Navy in Taranto for evaluating their psychophysical fitness to compulsory recruitment and referred to the Department of Dermatology of the Italian Navy Hospital for dermatological examination [5]. In this population, 157 CMN were diagnosed, with a prevalence of 1:148 or 0.67% (Bayesian 95% confidence interval 0.57–0.79) [6].…”

Section: Methodsmentioning

confidence: 99%

Reproducibility of Dermoscopic Features of Congenital Melanocytic Nevi

et al. 2008

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Background: The dermoscopic features of congenital melanocytic nevi (CMN) have recently been described, and some structures have been proposed as distinctive of these moles. Objective: The aim of our study was to evaluate the agreement between observers, i.e. the reproducibility, in the identification of these features. Method: Fifty-two CMN, randomly selected from 127 male subjects carrying at least 1 CMN, were examined by a 1st medium-experienced observer. The image recording was performed according to the dermoscopic patterns of the Consensus Net Meeting on Dermoscopy and to the features proposed for CMN by Seidenari et al. The presence/absence of these features was recorded in a specifically developed patient’s card, and the most typical dermoscopic features of the lesions were also photographed and observed again in this form by the same investigator and by a 2nd basic-experienced observer. The reproducibility of the dermoscopic features assessed directly and on photographs by the 1st observer (intraobserver agreement) and the agreement between the 1st and the 2nd observers judging nevi on photographs (interobserver agreement) were estimated by Cohen’s kappa statistics. Results: Intraobserver agreement was highly satisfactory for all the dermoscopic features, with the exception of focal thickening of network lines and follicles (satisfactory), and hyperpigmented areas and target vessels (fairly satisfactory), which were more frequently identified on Dermaphot pictures. Interobserver agreementwas highly satisfactory for network, globules/dots, blotches, focal hypopigmentation, skin furrow hypopigmentation and follicles; it was satisfactoryfor perifollicular hypopigmentation, vessels and target vessels, and barely satisfactory for focal thickening of network lines, target globules and hyperpigmented areas; finally, it was fairly satisfactory for target network. Conclusion: The identification of dermoscopic features of CMN seems to show a good reproducibility, with a satisfactory intra- and interobserver agreement. Other studies involving a higher number of experienced and less experienced observers are requested to confirm these results.

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The ‘EpiEnlist’ project: a dermo‐epidemiologic study on a representative sample of young Italian males. Prevalence of selected pigmentary lesions

Cited by 38 publications

References 45 publications

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Perfil epidemiológico dos pacientes com vitiligo e sua associação com doenças da tireoide

Prevalence of thyroid dysfunction and anti-thyroid peroxidase antibodies in vitiligo patients

Reproducibility of Dermoscopic Features of Congenital Melanocytic Nevi

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