The EORTC Modular Approach to Quality of Life Assessment in Oncology

Aaronson, Neil K.; Cull, Ann; Kaasa, Stein; Sprangers, M. A. G.

doi:10.1080/00207411.1994.11449284

Cited by 108 publications

(68 citation statements)

References 29 publications

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“…Three quarters of the patients completed the study including two assessments at a 3-week interval. The questionnaires used included the generic, validated quality of life core questionnaire of the EORTC (QLQ-C30) and its two specific modules on head and neck cancer (H&N35) and on oesophageal cancer (OES24) (Patrick and Deyo, 1989;Aaronson et al, 1993Aaronson et al, , 1994Guyatt et al, 1995), and a specifically developed questionnaire aiming at evaluating the tolerance of HETF since no instrument was available. It is well established that quality of life or related measures are better assessed using selfadministered questionnaires (Osoba, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…The French language validated self-administered questionnaire of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 core questionnaire (Aaronson et al, 1994) was used to appreciate generic quality of life data. The head and neck (H&N35) (Bjordal et al, 1999) and the oesophageal (OES24) (Blazeby et al, 1996) modules developed by the EORTC were added to evaluate the head and neck or oesophageal diseasetargeted measures of quality of life.…”

Section: Study Measuresmentioning

confidence: 99%

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Quality of life and home enteral tube feeding: a French prospective study in patients with head and neck or oesophageal cancer

et al. 2000

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Summary A prospective study was conducted to evaluate the impact of home enteral tube feeding on quality of life in 39 consecutive patients treated for head and neck or oesophageal cancer at the Centre François Baclesse in Caen, France. Patients were taken as their own controls. Quality of life was evaluated using the EORTC QLQ-C30 core questionnaire, and the EORTC H&N35 and OES24 specific questionnaires. The feeding technique tolerance was evaluated using a questionnaire specifically developed for this study. Two evaluations were made, the first a week after hospital discharge (n = 39) and the second 3 weeks later (n = 30). Overall, the global health status/quality of life scale score slightly improved; among symptoms, scale scores that significantly improved (P < 0.05) concerned constipation, coughing, social functioning and body image/sexuality. The physical feeding technique tolerance was acceptable while the technique was psychologically less tolerated with two-thirds of the patients longing to have the tube removed. One third of the patients was also uncomfortable about their body image. Home enteral tube feeding was responsible for not visiting family or close relations in 15% of patients, and not going out in public in 23%. We conclude that home enteral tube feeding is a physically well accepted technique although a substantial proportion of patients may experience psychosocial distress.

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Section: Discussionmentioning

confidence: 99%

Section: Study Measuresmentioning

confidence: 99%

Quality of life and home enteral tube feeding: a French prospective study in patients with head and neck or oesophageal cancer

et al. 2000

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“…At the start and end of treatment and also 6 weeks later, quality of life was measured with a standardized and validated questionnaire (i.e. EORTC-QLQ-C30 and LC-13) (Aaronson et al, 1994), that was filled in by the patient at home and posted anonymously to the data management of the study group. This questionnaire describes six functional scales, for which a higher percentage means a better functional performance.…”

Section: Evaluation Of Tumour Response and Quality Of Lifementioning

confidence: 99%

Activity of high-dose epirubicin combined with gemcitabine in advanced non-small-cell lung cancer: a multicenter phase I and II study

Putten¹,

Eppinga

Erjavec³

et al. 2000

Br J Cancer

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SummaryThe aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days 1 and 8 of a 21-day cycle. Eighteen patients were included in the phase I part of the study before the maximum tolerated dose was found. Dose-limiting toxicity was febrile neutropenia. The phase II part of the study was continued with epirubicin 100 mg m -2 on day 1 and gemcitabine 1125 mg m -2 on days 1 and 8 of a 21-day cycle. Forty-three chemotherapy-naive patients were included. The median age of the patients was 60 years (range 26-75). Most patients (74%) were in stage IV. Granulocytopenia CTC grade 4 occurred in 32.5% and thrombocytopenia grade 4 in 11.6% of cycles. Febrile neutropenia occurred in six patients. Nonhaematological toxicity was mainly mucositis CTC grade 2 and 3 in 35% of patients. The tumour response rate was 49% (95% confidence interval (CI) 35-63%). The median survival time for the patients was 42 weeks (95% CI 13-69).

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“…La adopción de esta estrategia de la evaluación modular intentaba reconciliar dos requisitos principales de la medida de la calidad de vida: 1) un grado suficiente de generalización para permitir las comparaciones entre estudios y 2) un nivel de especificidad adecuado en las investigaciones para hacer frente a cuestiones de especial relevancia en un determinado ensayo clínico (Aaronson, Cull, Kaasa, y Sprangers, 1994;Aaronson, Cull, Kaasa, y Sprangers, 1995;Aaronson et al, 1993;Kiebert y Kaasa, 1996 2. Asesorar a la EORTC sobre la evaluación de la calidad de vida de los pacientes, como uno de los resultados del tratamiento del cáncer.…”

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“…(Aaronson, Cull, Kaasa, y Sprangers, 1994;Aaronson, Cull, Kaasa, y Sprangers, 1995;Aaronson et al, 1993;De Boer, Sprangers, Aaronson, Lange, y Van Dam, 1996). Existen tres versiones de este instrumento, versiones 1.0, 2.0 y 3.0.…”

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Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado

Pérez

2016

Psicooncología

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The EORTC Modular Approach to Quality of Life Assessment in Oncology

Cited by 108 publications

References 29 publications

Quality of life and home enteral tube feeding: a French prospective study in patients with head and neck or oesophageal cancer

Quality of life and home enteral tube feeding: a French prospective study in patients with head and neck or oesophageal cancer

Activity of high-dose epirubicin combined with gemcitabine in advanced non-small-cell lung cancer: a multicenter phase I and II study

Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado

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