The enzyme thermistor—A realistic biosensor concept. A critical review

Yakovleva, Maria; Bhand, Sunil; Danielsson, Bengt

doi:10.1016/j.aca.2012.12.004

Cited by 67 publications

(31 citation statements)

References 65 publications

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“…The sensor transduction systems can operate according to different physical principles. Sensing devices based on calorimetric (Yakovleva et al 2013), gravimetric (Pohanka 2018), optical (Borisov and Wolfbeis 2008), and electrochemical transducers have been reported. Some of them aimed at the determination of PAs showed excellent analytical performances (Kuo et al 2018).…”

Section: Methods For the Determination Of Polyaminesmentioning

confidence: 99%

Endogenous and food-derived polyamines: determination by electrochemical sensing

et al. 2018

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Polyamines (PAs) are involved in a variety of fundamental physio-pathologic processes. The concentration of these polycations in organs and tissues depends on their endogenous production and oxidation rates, and on their intake from foods. Besides being largely accepted as markers for the progress of several pathologies, PAs may exert themselves different effects on humans, ranging from being positive to be drastically detrimental depending on the organism conditions. Thus, if the determination of polyamines content in tissue samples is of great importance as they could be indicators of several diseases, their quantification in food is fundamental for modulating the diet to respond to a specific human health status. Thus, the determination of PA content in food is increasingly urgent. Standard analytical methods for polyamine quantification are mainly based on chromatography, where high-performance liquid chromatography and gas chromatography are the most often used, involving pre-column or post-column derivatization techniques. Driven by the growing need for rapid in situ analyses, electrochemical biosensors, comprising various combinations of different enzymes or nanomaterials for the selective bio-recognition and detection, are emerging as competitors of standard detection systems. The present review is aimed at providing an up-to-date overview on the recent progresses in the development of sensors and biosensors for the detection of polyamines in human tissues and food samples. Basic principles of different electrochemical (bio)sensor formats are reported and the applications in human tissues and in foods was evidenced.

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Section: Methods For the Determination Of Polyaminesmentioning

confidence: 99%

Endogenous and food-derived polyamines: determination by electrochemical sensing

et al. 2018

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“…General reviews of biosensors and their application for bioprocess monitoring are available in the literature [38,[52][53][54]. Other reviews focus on specific biosensor classes, including calorimetric [52,[55][56][57], optical [39,41], and electrochemical biosensors [38,43,44].…”

Section: Biosensorsmentioning

confidence: 99%

Sensor systems for bioprocess monitoring

Biechele

Busse

Solle

et al. 2015

Engineering in Life Sciences

168

158

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The ability to measure all process variables is of great importance in the field of bioprocess monitoring and control, and continuous, real‐time measurements are highly desired. The more complete and real‐time the measurements are, the more stable, reproducible, and efficient the process can be, leading to reproducibly high‐quality products. This additional information allows the operator to better document the entire process. The process analytical technologies initiative of the US Food and Drug Administration is strongly related to the analysis and control of biopharmaceutical processes. The aim of the initiative is to create processes, generating products of ensured quality by measuring quality‐related process variables. The quality of the product is enhanced by a deep understanding of the process, which is enabled by an effective and suitable sensor system. The aim of this review is to provide an overview of current and emerging sensors for bioprocess monitoring. Sensors directly interfaced to bioreactors for measuring important variables from the gas phase, such as oxygen and carbon dioxide concentration, are discussed, as well as sensors for the monitoring of the biomass concentration and morphology and of the changing medium composition. Furthermore, sensor systems are discussed. These involve sensors (especially biosensors) that are not implemented directly inside the bioreactor but rather are used in conjunction with sample‐taking systems such as flow injection analysis. A major focus is given to spectroscopic sensors, which are noninvasive and offer interesting options for a simultaneous analysis of various compounds. Since data handling is extremely important for this kind of sensor, chemometrics are also included. Soft sensors are discussed as technology that allows a user to incorporate more process data as it become available. Finally, the current state of disposable sensor technology is presented. These sensors are needed for the growing area of disposable and continuous biomanufacturing.

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“…Yakovleva et al have recently published an article describing enzyme thermistors, which, according to the authors, have the potential to become almost universal biosensors (Yakovleva et al, 2013). In these devices, typically an enzyme reactor is coupled to a thermistor, but other types of biorecognition elements can also be used, such as whole cells, organelles or even tissue.…”

Section: Miscellaneous Thermometricmentioning

confidence: 99%