Recent advances in lab-on-a-chip for biosensing applications

Lafleur, Josiane; Jonsson, Ann‐Beth; Senkbeil, Silja; Kutter, Jörg Peter

doi:10.1016/j.bios.2015.08.003

Cited by 208 publications

(110 citation statements)

References 178 publications

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“…A closely related field that is arguably the precursor of chemical micro-processing is microfluidics [8][9][10][11]. The main aim of microfluidics [12,13] is to scale down and integrate laboratory functions in a miniaturized chip format termed lab-on-a-chip [14]. Some applications of these microfluidic devices include point-of-care diagnostics [15,16], cell biology and biochemical analysis [17], high-throughput screening in drug discovery [18], genomics [19] and proteomics [20].…”

Section: Introductionmentioning

confidence: 99%

Experimental study of efficient mixing in a micro-fluidized bed

Živković

Ridge

Biggs

2017

Applied Thermal Engineering

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Section: Introductionmentioning

confidence: 99%

Experimental study of efficient mixing in a micro-fluidized bed

Živković

Ridge

Biggs

2017

Applied Thermal Engineering

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“…However, these strategies can also be integrated in a microfluidic configuration for developing point-of-care (POC) external miniaturized devices. 145,146 Ang et al have demonstrated an array of graphene-FET constructed on a quartz-substrate that was integrated with microfluidic flow cytometry for sensing malaria infected blood cells at a single cell level. The infected blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene through charge protrusions on cell surface that induces local doping thereby changing the FET characteristics.…”

Section: Microfluidics and Other Biosensing Systemmentioning

confidence: 99%

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

2017

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Graphene has emerged as a champion material for a variety of applications cutting across multiple disciplines in science and engineering. Graphene and its derivatives have displayed huge potential as a biosensing material due to their unique physicochemical properties, good electrical conductivity, optical properties, biocompatibility, ease of functionalization, and flexibility. Their widespread use in making biosensors has opened up new possibilities for early diagnosis of life-threatening diseases and real-time health monitoring. Following an introduction and discussion on the significance of fabrication protocols and assembly, this review is intended to assess why graphene is suitable to build better biosensors, the working of existing biosensing schemes and their current status toward commercialization for wearable diagnostic and prognostic devices. We believe this review will provide a critical insight for harnessing graphene as a suitable biosensor for the clinical diagnostics, its future prospects and challenges ahead.

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“…Referring to the state of the art in the recently developed LOC methods (64), it can be observed that they are based on nucleic acid amplification, biosensoristic devices, flow cytometry, spectrometry techniques, and multisensors systems.…”

Section: Emerging Role Of Portable Bio/chemosensoristic Devices In Enmentioning

confidence: 99%

Portable Bio/Chemosensoristic Devices: Innovative Systems for Environmental Health and Food Safety Diagnostics

Dragone

Grasso

Muccini

et al. 2017

Front. Public Health

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This mini-review covers the newly developed biosensoristic and chemosensoristic devices described in recent literature for detection of contaminants in both environmental and food real matrices. Current needs in environmental and food surveillance of contaminants require new simplified, sensitive systems, which are portable and allow for rapid and on-site monitoring and diagnostics. Here, we focus on optical and electrochemical bio/chemosensoristic devices as promising tools with interesting analytical features that can be potentially exploited for innovative on-site and real-time applications for diagnostics and monitoring of environmental and food matrices (e.g., agricultural waters and milk). In near future, suitably developed and implemented bio/chemosensoristic devices will be a new and modern technological solution for the identification of new quality and safety marker indexes as well as for a more proper and complete characterization of abovementioned environmental and food matrices. Integrated bio/chemosensoristic devices can also allow an “holistic approach” that may prove to be more suitable for diagnostics of environmental and food real matrices, where the copresence of more bioactive substances is frequent. Therefore, this approach can be focused on the determination of net effect (mixture effect) of bioactive substances present in real matrices.

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Recent advances in lab-on-a-chip for biosensing applications

Cited by 208 publications

References 178 publications

Experimental study of efficient mixing in a micro-fluidized bed

Experimental study of efficient mixing in a micro-fluidized bed

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

Portable Bio/Chemosensoristic Devices: Innovative Systems for Environmental Health and Food Safety Diagnostics

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