The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose

Penza, M.; Jeremic, Marija; Marrazzo, Eleonora; Maggi, Adriana; Ciana, Paolo; Rando, Gianpaolo; Grigolato, Piergiovanni; Lorenzo, Diego Di

doi:10.1016/j.taap.2011.05.017

Cited by 77 publications

(57 citation statements)

References 77 publications

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“…In addition, TBT exposure results in various degrees of adiposity and induces metabolic disorders by modulating PPAR␥ activity (29,(105)(106)(107)(108)(109)(110). In agreement with these previous findings, both groups of TBT rats displayed distinct evidence of an increase in lipid droplet accumulation and PPAR␥ protein expression levels in the adrenal cortex.…”

Section: Discussionsupporting

confidence: 89%

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

et al. 2016

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Tributyltin chloride (TBT) is an environmental contaminant that is used as a biocide in antifouling paints. TBT has been shown to induce endocrine-disrupting effects. However, studies evaluating the effects of TBT on the hypothalamus-pituitary-adrenal (HPA) axis are especially rare. The current study demonstrates that exposure to TBT is critically responsible for the improper function of the mammalian HPA axis as well as the development of abnormal morphophysiology in the pituitary and adrenal glands. Female rats were treated with TBT, and their HPA axis morphophysiology was assessed. High CRH and low ACTH expression and high plasma corticosterone levels were detected in TBT rats. In addition, TBT leads to an increased in the inducible nitric oxide synthase protein expression in the hypothalamus of TBT rats. Morphophysiological abnormalities, including increases in inflammation, a disrupted cellular redox balance, apoptosis, and collagen deposition in the pituitary and adrenal glands, were observed in TBT rats. Increases in adiposity and peroxisome proliferator-activated receptor-γ protein expression in the adrenal gland were observed in TBT rats. Together, these data provide in vivo evidence that TBT leads to functional dissociation between CRH, ACTH, and costicosterone, which could be associated an inflammation and increased of inducible nitric oxide synthase expression in hypothalamus. Thus, TBT exerts toxic effects at different levels on the HPA axis function.

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Section: Discussionsupporting

confidence: 89%

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

et al. 2016

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“…Activation of the PPARγ–RXR heterodimer has been found to favor lipid biosynthesis and storage, and induces adipocyte differentiation. Interestingly, a recent report indicated that tributyltin can work as a xenoestrogen via estrogen receptors in vivo [119]. Among commonly used phthalates as plasticizers, monoethyl-hexyl-phthalate can work as an activator for PPARγ [120].…”

Section: Role Of Chemicalsmentioning

confidence: 99%

Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals

Inadera

2013

Environ Health Prev Med

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Obesity is a leading risk factor for impaired glucose tolerance and type 2 diabetes (T2D). Although the cause of the obesity epidemic is multi-factorial and not entirely clear, the recent acceleration in incidence is too rapid to be accounted for only by genetics, the wide availability of calorie-rich foods, and increasingly sedentary lifestyles. Accumulating data suggest that the important causes of the obesity epidemic may be related to developmental and early life environmental conditions. The concept of the developmental origins of health and disease (DOHaD) suggests that adverse influences early in development, particularly during intrauterine life, may result in permanent changes in the physiology and metabolism of the infant, which in turn result in an increased risk of non-communicable diseases in adulthood. For example, undernutrition during pregnancy and rapid postnatal weight gain are associated with obesity and T2D in the adult offspring. Moreover, increasing evidence suggests that early-life exposure to a wide range of chemicals has a significant impact on the causes of metabolic disorders. Although the underlying molecular mechanisms remain to be determined, these factors can affect epigenetic processes, such as DNA methylation, allowing the developmental environment to modulate gene transcription. The objective of this review article was to summarize recent progress in the biomedical implications of the DOHaD concept, focusing on the pathogenesis of obesity and T2D, and to discuss a future direction for preventive strategies from a public health perspective.

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“…TBT is considered as a kind of obesogen, chiefly for its action on fat tissue inducing the differentiation of preadipocytes from adipocytes [11,13,24]. In our previous study, hepatic dysfunction, as well as a rise in plasmatic levels of insulin, leptin, and resistin, was observed [1].…”

Section: Discussionmentioning

confidence: 88%

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Zhang

Chen

2015

Endokrynologia Polska

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Introduction: Tributyltin (TBT) is a largely diffused environmental pollutant. Several studies have demonstrated that TBT is involved in the development of obesity. However, few studies addressing the effects of TBT on the brain neuropeptides involved in appetite and body weight homeostasis have been published. Material and methods: Experiments were carried out on female and male Sprague-Dawley rats. Animals were exposed to TBT (0.5 μg/kg body weight) for 54 days. The hepatic triglyceride and total cholesterol were determined using commercial enzyme kits. The NPY, AgRP, POMC and CART mRNA expression in brains were quantified by real-time PCR. Results: TBT exposure resulted in significant increases in the hepatic total cholesterol and triglyceride concentration of both male and female rats. Interestingly, increases in body weight and fat mass were only found in the TBT-treated male rats. TBT exposure also led to a significant increase in food intake by the female rats, while no change was observed in the male rats. Moreover, the neuropeptides expression was different between males and females after TBT exposure. TBT induced brain NPY expression in the female rats, and depressed brain POMC, AgRP and CART expression in the males. Conclusions: TBT can increase food intake in female rats, which is associated with the disturbance of NPY in brains. TBT had sex-different effects on brain NPY, AgRP, POMC and CART mRNA expression, which indicates a complex neuroendocrine mechanism of TBT.

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The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose

Cited by 77 publications

References 77 publications

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats

Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

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