The entrapment of kojic oleate in bilayer vesicles

Manosroi, Aranya; Wongtrakul, Paveena; Manosroi, Jiradej; Midorikawa, U.; Hanyu, Yoshiro; Yuasa, Makoto; Sugawara, Fumio; Sakai, Hideki; Abe, Masahiko

doi:10.1016/j.ijpharm.2005.02.041

Cited by 30 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Langmuir monolayer technique is a good method to explore the self-assembling behavior of amphiphiles and hydrophobic particles at interfaces and the Langmuir-Blodgett film technique is used to prepare functional self-assembled monolayers or films [17,18]. Furthermore, the Langmuir monolayer method was also used to explore the possible entrapment of amphiphilic drugs in lipid vesicles [19], or understand the formulation of liposomes [10]. In this study, the Langmuir monolayer method was used to explore the energy changes when the various ratios of components in the nanoassemblies were mixed.…”

Section: Formulation Optimization Based On Langmuir Monolayer Behaviormentioning

confidence: 99%

Rational design of didodecyldimethylammonium bromide-based nanoassemblies for gene delivery

Jin

Wang

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Formulation Optimization Based On Langmuir Monolayer Behaviormentioning

confidence: 99%

Rational design of didodecyldimethylammonium bromide-based nanoassemblies for gene delivery

Jin

Wang

et al. 2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…These carriers are advantageous because they increase drug stability, enhance therapeutic effects, prolong circulation time in a biological environment, and promote the uptake of the entrapped drugs into the target site while drug toxicity is diminished due to a reduction in nonspecific tissue uptake. 15 Niosomes are capable of encapsulating both hydrophilic and lipophilic drugs and can serve as effective drug carriers. 16 The vesicles serve as a soluble matrix and also serve as a local depot for sustained drug release; permeation enhancers of dermally active compounds; or a rate-limiting membrane barrier for the modulation of systemic absorption of drugs via dermal drug delivery.…”

mentioning

confidence: 99%

Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity

Gupta

Singh

Kotla

et al. 2014

IJN

View full text Add to dashboard Cite

A skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. One of the best options for successful drug delivery to the affected area of skin is the use of elastic vesicles (niosomes) which can be transported through the skin through channel-like structures. In this study, a combination of tretinoin (keratolytic agent) and benzoyl peroxide (BPO) (a potent antibacterial) was given by using niosomes as promising carriers for the effective treatment of acne by acting on a pathogenic site. In this section, niosomal gel formulation encapsulated drugs have been evaluated for in vitro, ex vivo, and in vivo, for their predetermined characteristics; and finally the stability of the niosome gel was tested at different temperature conditions for understanding of the storage conditions required for maintaining the quality of formulation attributes. The prepared niosome was found to be in the range of 531 nm with a zeta potential of −43 mV; the entrapment efficiencies of tretinoin (TRA) and BPO niosomes were found to be 96.25%±0.56% and 98.75%±1.25%, respectively. The permeated amount of TRA and BPO from the niosomal gel after 24 hours was calculated as 6.25±0.14 μg/cm 2 and 5.04±0.014 μg/cm 2 , respectively. A comparative drug retention study in Wistar rat skin using cream, an alcoholic solution, and a niosomal gel showed 11.54 μg, 2.68 μg, and 15.54 μg amounts of TRA and 68.85 μg, 59.98 μg, and 143.78 μg amounts of BPO were retained in the layers of skin, respectively. In vivo studies of the niosomal gel and antiacne cream of TRA and BPO showed that the niosomal gel was more efficacious than the antiacne cream because niosomal gels with a 4.16-fold lower dose of BPO provided the same therapeutic index at targeted sites in comparison to the antiacne cream.

show abstract

“…Gallidermin is mainly promising for the dermal and cosmetic treatment of acne in human medicines because of its greatly active against Propionibacterium acnes and treatment of multidrug resistant Staphylococcus Aureus strains, which is a snowballing problem especially in the hospitals (Kempf et al, 1999). Gallidermin has limited absorption through skin and chemical instability due to its large molecular structure and peptide nature, respectively (Manosroi et al, 2005). Anionic niosomal gallidermin composed of tween 61/cholesterol /dicetylphosphate prepared and antibacterial activity of formulations against Propionibacterium acnes and Staphylococcus Aureus assayed with macrodilution method to determine the minimal concentration of the sample necessary to inhibit or kill the microorganisms.…”

Section: Acnementioning

confidence: 99%