The enterohepatic circulation in glutethimide intoxication

Tan, Chaim Chary

doi:10.1002/cpt1970116816

Cited by 8 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One method of studying the EHC is to compare the biologic half-lives of a substance and its metabolites in normal animals with that in animals with a bile fistula (KEBERLE et aI., 1962;CHARYTAN, 1970). Another approach is to compare the amounts of substances excreted in the bile of animals with bile fistulas to the amounts excreted in the feces and urine of normal animals (WOODS, 1954;DOBBS and HALL, 1969;CALDWELL et aI., 1971).…”

Section: Methods For Studying the Enterohepatic Circulationmentioning

confidence: 99%

Concepts in Biochemical Pharmacology

Brodie¹,

Gillette²,

Ackerman³

1975

View full text Add to dashboard Cite

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publlsher, the amount of the fee to be determined by agreement with the publisher. © by Springer-Verlag Berlin· Heidelberg 1975. Softcover reprint of the hardcover ist edition 1975 Library of Congress Cataloging in Publication Data (Revised) Main entry under title: Concepts in biochemical pharmacology. Handbuch der experlmentellen Pharmakologie. Handbook of experimental pharmacology. New series, v. XXVIII, 1, etc. Includes bibliographies. I. Drug metabolism-Collected works.!. Argy, W. P. II. Brodie, B. B., ed. III. Gillette, James R., 1928-ed. IV. Ackerman, Helen S., ed. V. Series: Handbuch der experimentellen Pharmakologle, v. XXVIII, 1 QP905.H3 Bd. 28, t. 1, etc. [RM301] 615'. 7 79-135957 ISBN 0-387-05134-1. The use of general descriptive names, trade names, trade marks, etc. in this pUblication, even if the former are not especially Identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordlngiy be used freely by anyone. PrefacePart 3 of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man.Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmacokinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader.Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, enterohepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.The section on drug interactions opens with a chapter in which all drug interactions are viewed as result...

show abstract

Section: Methods For Studying the Enterohepatic Circulationmentioning

confidence: 99%

Concepts in Biochemical Pharmacology

Brodie¹,

Gillette²,

Ackerman³

1975

View full text Add to dashboard Cite

show abstract

The Enterohepatic Circulation of Bile Salts

Small¹

1972

Arch Intern Med

136

View full text Add to dashboard Cite

Bile salts secreted by the liver pass into the intestine, are absorbed in large part by the ileum, and return to the liver by way of the portal vein, thus completing a portal enterohepatic circulation (EHC). An extraportal EHC also exists, which is minor in health but may become a major determinant of bile metabolism in disease. A long-term monkey preparation allows direct measurement of bile volume, secretory rates of bile salts and biliary lipids, bile salt synthetic rates and pool size, and intestinal absorption in both the Substances secreted by the liv-1 er, absorbed by the intestine, and resecreted by the liver have an enterohepatic circulation (EHC). However, the degree to which a sub¬ stance undergoes EHC may vary from the extreme example of bile salts in which nearly all of the bile salt secreted into the intestine is reabsorbed and resecreted by the liver to compounds in which only a very small fraction of the total quan¬ tity secreted by the liver is reab¬ sorbed to reappear in the bile. From an anatomical point of view, the en¬ terohepatic circulation is divided into two clearly different pathways (Fig 1): the portal EHC and the extrapor¬ tal EHC. Compounds having a portal

show abstract

Biliary Excretion

Klaassen

1977

Comprehensive Physiology

View full text Add to dashboard Cite

The enterohepatic circulation in glutethimide intoxication

Cited by 8 publications

References 1 publication

Concepts in Biochemical Pharmacology

Concepts in Biochemical Pharmacology

The Enterohepatic Circulation of Bile Salts

Biliary Excretion

Contact Info

Product

Resources

About