Biliary Excretion

Klaassen, Curtis D.

doi:10.1002/cphy.cp090134

Cited by 2 publications

(1 citation statement)

References 126 publications

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“…A carrier-mediated transport system for biliary excretion of organic cations has been demonstrated in the rat [6,12,16]. It may be hypothesized that rat liver concentrates erythromycin in the bile through a special ized transport process which may be acti vated by given enzyme inducers, similarly to hepatic transport systems of organic anions and neutral compounds [6].…”

Section: Discussionmentioning

confidence: 99%

Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats

Manzo¹,

Gregotti²,

Richelmi³

et al. 1980

Chemotherapy

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The administration of phenobarbitone to the rat (8 mg/100 g BW) once daily for 3 days significantly decreased the serum and tissue levels of erythromycin administered intraperitoneally (5 mg/l00 g BW). Furthermore, phenobarbitone stimulated the hepatic microsomal N-demethylation of erythromycin and increased the biliary concentration and the biliary excretion rate of the unmetabolized antibiotic. These effects were accompanied by augmented liver mass and bile flow. The possibility is discussed that erythromycin concentrates in the bile through a specialized hepatic drug transport system, activated by phenobarbitone.

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Section: Discussionmentioning

confidence: 99%

Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats

Manzo¹,

Gregotti²,

Richelmi³

et al. 1980

Chemotherapy

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Effect of polybrominated biphenyls on hepatic excretory function in rats and mice.

Cagen¹,

Gibson²

1978

Environ Health Perspect

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The purpose of this investigation was to determine the influence of polybrominated biphenyls (PBBs) on hepatic excretory function in developing and adult rats and mice. Prenatal or postnatal dietary exposure to PBBs (50 ppm in diet of pregnant or lactating mother or in diet of rat weanlings) resulted in elevated liver weight in developing rats. In 15-day-old rats that had been treated with PBBs increased liver weight correlated to enhanced ouabain transport from plasma into bile. Liver weight was also elevated in 21, 35, and 49-day-old rats exposed to PBBs, but this effect was not associated with stimulation of ouabain transport in these animals. However, adult rats fed 100 ppm PBBs for two weeks had significantly lower plasma concentrations of sulfobromophthalein (BSP) and increased biliary excretion of BSP, when compared to controls. PBBs-fed adult rats also excreted a greater percentage conjugated BSP (BSP-GSH) into bile. Two week dietary treatment of 100, 150, and 200 ppm PBBs resulted in enhanced initial disappearance of indocyanine green (ICG) from plasma of adult mice. However, dietary doses of 100 and 200 ppm PBBs to adult mice was not associated with enhanced capacity for ouabain excretion. In contrast, treatment with PBBs through the mother's diet (50 ppm) resulted in an almost twofold increase in cumulative ouabain excretion in 15-day-old mice. The results suggest that PBBs stimulate hepatic drug elimination in rats and mice, but the magnitude of the effect is dependent on age and transported compound.

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Biliary Excretion

Cited by 2 publications

References 126 publications

Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats

Effects of Phenobarbitone on the Distribution, Metabolism and Biliary Excretion of Erythromycin in Rats

Effect of polybrominated biphenyls on hepatic excretory function in rats and mice.

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