The enigma of skin allograft rejection

Steinmuller, David

doi:10.1016/s0955-470x(98)80039-6

Cited by 43 publications

(28 citation statements)

References 107 publications

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“…Skin, small bowel, and lung seem to be the most susceptible to rejection; whereas pancreatic islets, vascularized pancreas, heart, kidney, and liver are progressively more easily accepted (1)(2)(3)(4)(5). Liver allografts perhaps should be classified separately in that they are often accepted without the need for immune modulation in the pig, rat, and mouse, and liver grafts are able to induce acceptance of and in some cases tolerance to other coexistent donor-type allografts (6).…”

mentioning

confidence: 99%

“…Evidence for the existence of tissue-specific alloantigens arose from observations in hemopoietic chimeras. In this situation, although allogeneic hemopoietic cells survived indefinitely, such chimeras would not accept skin grafts from the same donor, suggesting that the skin-expressed Ags not found on the hemopoietic cells (5,9). Indeed, Skn and Epa-1, two skin-specific Ags, have been implicated as targets for skin graft rejection in some models (5,10,11).…”

mentioning

confidence: 99%

“…Skin contains numerous Langerhans cells (LC) 5 which are professional APCs with the capacity to migrate from the graft and efficiently stimulate recipient T cells (12,13). Thus, the potential for a skin graft to stimulate large numbers of alloreactive T cells may explain why these grafts are so susceptible to rejection.…”

mentioning

confidence: 99%

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Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection

Jones

Turvey

Maurik

et al. 2001

The Journal of Immunology

164

135

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Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2Kb+ skin and islet allografts to rejection is not based on their ability to activate more H-2Kb-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2Kb-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.

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confidence: 99%

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confidence: 99%

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Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection

Jones

Turvey

Maurik

et al. 2001

The Journal of Immunology

164

135

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“…The method of skin allograft transferral may influence its immunogenicity: primarily vascularized skin allografts have a small survival advantage over secondarily vascularized skin allografts in some studies [18,19]. Possible mechanisms for the difference in immunogenicity between primarily and secondarily vascularized skin allografts are initial post-transplant ischemic damage and the route of interaction of the allograft with the recipient immune system.…”

Section: Mode Of Transplantationmentioning

confidence: 99%

“…Consequently, Epa-1 can trigger rejection of other tissues (e.g. heart) [18]. The other tissues on which Epa-1 is expressed are less immunogenic than skin, suggesting that the cause of skin antigenicity is not just Epa-1.…”

Section: Epa-1 Antigenmentioning

confidence: 99%