Skin tolerance: in search of the Holy Grail

Horner, B. M.; Randolph, Mark A.; Huang, Christene A.; Butler, Peter E. M.

doi:10.1111/j.1432-2277.2007.00559.x

Cited by 20 publications

(23 citation statements)

References 122 publications

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“…In addition, all of the hand transplants have experienced episodes of acute rejection that required treatment. 3,4,[23][24][25][26] This might be a result of the relative increase in antigenicity over the more homogenous classic organ allografts due in part to the presence of multiple tissue types (especially the skin). These factors explain the limited support for transplanting hands (only 16% of respondents) with the currently available immunosuppressive regimens.…”

Section: Discussionmentioning

confidence: 97%

A Survey of North American Hand Surgeons on Their Current Attitudes Toward Hand Transplantation

Mathes

Schlenker

Ploplys

et al. 2009

The Journal of Hand Surgery

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Section: Discussionmentioning

confidence: 97%

A Survey of North American Hand Surgeons on Their Current Attitudes Toward Hand Transplantation

Mathes

Schlenker

Ploplys

et al. 2009

The Journal of Hand Surgery

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“…KCs are capable of processing and presenting antigen directly (Kim et al, 2009), although transgenic antigens expressed in KCs can also be cross-presented by local CD103 þ antigen-presenting cells (Bedoui et al, 2009). The precise effector mechanisms leading to skin graft rejection by MHC class I-or II-restricted T cells are undefined (Horner et al, 2008). However, as shown in this study, neighboring grafts not showing antigen are not damaged by immune destruction of antigen-bearing grafts, and in an allophenic MHC class I-restricted mouse model, cell destruction is specific to the epithelial cells presenting alloantigen and spares adjacent cells not presenting antigen (Singer and Rosenberg, 1988), suggesting that epithelial cell and effector T-cell contact specifically determines cell death.…”

Section: Discussionmentioning

confidence: 99%

Antigen-Specific CD8 T Cells Can Eliminate Antigen-Bearing Keratinocytes with Clonogenic Potential via an IFN-γ-Dependent Mechanism

Kluyver

Moritz

Harris

et al. 2010

Journal of Investigative Dermatology

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The immune system surveys the skin for keratinocytes (KCs) infected by viruses or with acquired genetic damage. The mechanism by which T cells mediate KC elimination is however undefined. In this study we show that antigen-specific CD8 T cells can eliminate antigen-bearing KCs in vivo and inhibit their clonogenic potential in vitro, independently of the effector molecules perforin and Fas-ligand (Fas-L). In contrast, IFN-gamma receptor expression on KCs and T cells producing IFN-gamma are each necessary and sufficient for in vitro inhibition of KC clonogenic potential. Thus, antigen-specific cytotoxic T lymphocytes (CTLs) may mediate destruction of epithelium expressing non-self antigen by eliminating KCs with potential for self-renewal through an IFN-gamma-dependent mechanism.

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“…This experimental model is still used as the gold standard in studies of transplant immunology including reconstructive sur-gery. After over six decades, however, the precise mechanism of skin allograft rejection remains still ill-defined 8 .…”

Section: Discussionmentioning

confidence: 99%

Experimental diabetes exacerbates skin transplant rejection in rats

Reis¹,

Sementilli

Gagliardi

2013

Acta Cir. Bras.

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PURPOSE:To investigate the effect of chronic experimental diabetes on skin allografts in rats as a simple model that could clarify some basic aspects and mechanisms involved in transplant rejection in diabetes compared to normal animals. METHODS:Skin grafting was performed with fragments of tail skin from sex matched non diabetic Wistar rats engrafted onto the thoracic area of diabetic and non diabetic recipients. Grafts were scored for rejection every other day and were removed on day 14.Skin grafts were graded according to the following itens: no rejection; or rejection including: acute, chronic and humoral and/or cellular rejection. Statistical analysis was performed using JMP 5.1 software with ANOVA test. Diabetes was induced with IV injection of alloxan 40 mg/kg. RESULTS:Inflammatory vascular infiltrate compromising the endothelium with areas of fibrinoid necrosis and thrombosis characteristics of acute humoral rejection and subendothelial lymphocyte infiltrate typical of acute cellular rejection were significantly (p<0.003) higher in diabetic than in non diabetic recipients as the inflammatory infiltrate in the epidermis (p<0.002). CONCLUSION:Skin transplant acute rejection from chronic alloxan diabetic rats to normal tissue was significantly more intense than the acute rejection between normal rats.

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Skin tolerance: in search of the Holy Grail

Cited by 20 publications

References 122 publications

A Survey of North American Hand Surgeons on Their Current Attitudes Toward Hand Transplantation

A Survey of North American Hand Surgeons on Their Current Attitudes Toward Hand Transplantation

Antigen-Specific CD8 T Cells Can Eliminate Antigen-Bearing Keratinocytes with Clonogenic Potential via an IFN-γ-Dependent Mechanism

Experimental diabetes exacerbates skin transplant rejection in rats

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