The Engineering of Craniofacial Tissues in the Laboratory: A Review of Biomaterials for Scaffolds and Implant Coatings

Abukawa, Harutsugi; Papadaki, Maria; Abulikemu, Mailikai; Leaf, Jeremy A.; Vacanti, Joseph P.; Kaban, Leonard B.; Troulis, Maria J.

doi:10.1016/j.cden.2005.11.006

Cited by 60 publications

(52 citation statements)

References 66 publications

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“…Of particular significance is the progress that has been made in the areas of implantable devices and drug/device combination products, such as drug-eluting stents, [1][2][3][4][5] artificial organs, 6-9 biosensors, 10,11 catheters, 12 scaffolds for tissue engineering, [13][14][15] and heart valves. 16,17 Nevertheless, the biocompatibility of implantable devices remains a critical issue in limiting device longevity and functionality, particularly in the case of biosensors.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response

Onuki

Bhardwaj

Papadimitrakopoulos

et al. 2008

J Diabetes Sci Technol

344

282

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In recent years, a variety of devices (drug-eluting stents, artificial organs, biosensors, catheters, scaffolds for tissue engineering, heart valves, etc.) have been developed for implantation into patients. However, when such devices are implanted into the body, the body can react to these in a number of different ways. These reactions can result in an unexpected risk for patients. Therefore, it is important to assess and optimize the biocompatibility of implantable devices. To date, numerous strategies have been investigated to overcome body reactions induced by the implantation of devices. This review focuses on the foreign body response and the approaches that have been taken to overcome this. The biological response following device implantation and the methods for biocompatibility evaluation are summarized. Then the risks of implantable devices and the challenges to overcome these problems are introduced. Specifically, the challenges used to overcome the functional loss of glucose sensors, restenosis after stent implantation, and calcification induced by implantable devices are discussed.

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Section: Introductionmentioning

confidence: 99%

A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response

Onuki

Bhardwaj

Papadimitrakopoulos

et al. 2008

J Diabetes Sci Technol

344

282

View full text Add to dashboard Cite

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“…However, bone substitute and grafting biomaterials are becoming increasingly important for all aspects of surgery and dentistry [1][2][3][4]. Within the broad range of biomaterials used in craniofacial bone surgery [5], calcium phosphate-based bioceramics, e.g. hydroxyapatite (HA) or β-tricalciumphosphate (β-TCP), are the most widely used and considered to be biocompatible, non-immunogenic and osteoconductive [57].…”

Section: Introductionmentioning

confidence: 99%

“…These factors negatively influence osteoconductivity and resorption at the implantation site. These bioceramics may therefore have a longer degradation time and even induce chronic inflammatory processes [5]. Recently, a granular material consisting of nanocrystalline HA embedded in a silica gel matrix [8] with an extremely large internal surface and a material porosity of about 60% [9] has been developed and approved.…”

Section: Introductionmentioning

confidence: 99%

A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig.

Götz

Lenz²,

Reichert³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:To test the probable osteoinductive properties of NanoBone®, a new highly non-sintered porous nano-crystalline hydroxylapatite bone substitute embedded into a silica gel matrix, granules were implanted subcutaneously and intramuscularly into the back region of 18 mini pigs. After periods of 5 and 10 weeks as well as 4 and 8 months, implantation sites were investigated using histological and histomorphometric procedures. Signs of early osteogenesis could already be detected after 5 weeks. The later periods were characterized by increasing membranous osteogenesis in and around the granules leading to the formation of bone-like structures showing periosteal and tendon-like structures with bone marrow and focal chondrogenesis. Bone formation was better in the subcutaneous than in the intramuscular implantation sites. This ectopic osteogenesis is discussed with regard to the nanoporosity and microporosity of the material, physico-chemical interactions at its surface, the differentiation of osteoblasts, the role of angiogenesis and the probable involvement of growth factors. The results of this preliminary study indicate that this biomaterial has osteoinductive potential and induces the formation of bone structures, mainly in subcutaneous adipose tissue in the pig.

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“…Typically, three groups of biomaterials are used to manufacture scaffolds: ceramic, synthetic polymers, and natural polymers [26] (table II). Biocompatible, similar to the inorganic component of bone, osteoconductiveness, absence of protein (providing lack of immune response) and high degradation time in vivo [2]. However, they have poor mechanical properties [27].…”

Section: Literature Reviewmentioning

confidence: 99%

“…The ceramics scaffolds such as hydroxyapatite and tricalcium phosphate, have been widely used in bone regeneration because of their biocompatibility, similarity to the inorganic component of bone, osteoconductiveness, absence of protein in their composition (providing lack of immune response) and because of its high degradation time in vivo [2], which allows bone remodeling at the site of grafting. Its disadvantages are its low structural stiffness (and may not be used in large mechanical stresses regions) and its porous nature, which increases the risk of fractures [36].…”

Section: Tricalcium Phosphatementioning

confidence: 99%

Stem cells carrier scaffolds for tissue engineering

Lopes

Levandowski

Fonseca

et al. 2017

RSBO

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The Engineering of Craniofacial Tissues in the Laboratory: A Review of Biomaterials for Scaffolds and Implant Coatings

Cited by 60 publications

References 66 publications

A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response

A Review of the Biocompatibility of Implantable Devices: Current Challenges to Overcome Foreign Body Response

A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig.

Stem cells carrier scaffolds for tissue engineering

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