The Endocannabinoid System as a Potential Therapeutic Target for HIV-1-Associated Neurocognitive Disorder

Chu, Liuxi; Zheng, Shusen; Gu, Xinpei; Wu, Yan; Yang, Jin; Deng, Huihua

doi:10.1089/can.2022.0267

Cited by 2 publications

(2 citation statements)

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“…Understanding of the ECS role in the modulation of appetite and metabolism has led to the key developments in medicine. Various medications are made to target the ECS to enhance appetite, especially in weak immune system as a result of cancer/AIDS where weight and appetite loss are typical [34]. A synthetic THC drug known as dronabinol has been developed to increase appetite and manage body weight.…”

Section: Appetite and Metabolismmentioning

confidence: 99%

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The Interplay between 2-Arachidonoylglycerol and Anandamide Amidohydrolase in Neuropathy

Ibrahim,

Ayariga,

et al. 2024

Preprint

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The endocannabinoid system (ECS) is a complex neuromodulatory network in the human body that have enormous impact in developing the central nervous system, as well as modulates various physiological processes. The ECS is made up of anandamide, 2-arachidonoylglycerol (2-AG), which are responsible for the synthesis and degradation of endocannabinoids, and enzymes such as FAAH and MAGL ensures the precise control over endocannabinoid levels. The ECS relies on CB1 receptors found in the central nervous system (CNS), and CB2 receptors found in the peripheral nervous system and immune cells. Dysregulation of the ECS has been associated with several health conditions, prompting investigations into its association with phytocannabinoids to harness their therapeutic potential. The ECS is intricately linked with the nervous system, and it is known to modulate neuronal activities in the CNS, influencing pain and mood modulation. The ECS is also associated with neuropathies-peripheral nerve damage leading to symptoms such as weakness, numbness and pain as evidenced in diabetic neuropathy, Guillain-Barré Syndrome, carpal tunnel syndrome, peripheral neuropathy, and postherpetic neuralgia. The focus of this review is on the interplay between 2-arachidonoylglycerol and anandamide amidohydrolase in neuropathy, elucidating their roles in pain regulation, inflammation, and specific neuropathies. The knowledge generated is expected to have broad implications, providing comprehensive insights into neuropathic conditions and how to improve on them. Ultimately, this understanding may lead to more effective treatments and improved quality of life for individuals affected by these conditions.

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Section: Appetite and Metabolismmentioning

confidence: 99%

“…Researchers are further exploring ways the ECS manipulated to help manage weight and obesity. This may be achieved by regulating the ECS's activity to reduce appetite and enhance the breakdown of adipose tissues [32][33][34].…”

Section: Appetite and Metabolismmentioning

confidence: 99%