The Emerging Roles of π Subunit-Containing GABA<sub>A</sub> Receptors in Different Cancers

Juvale, Iman Imtiyaz Ahmed; Hassan, Zurina; Has, Ahmad Tarmizi Che

doi:10.7150/ijms.60928

Cited by 8 publications

(4 citation statements)

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“…Cancer research has also revealed coagulation-related events during tumor onset, progression, and metastasis [ 50 ]; coagulation factors can be abundantly expressed in gastric cancer [ 51 ]; and differentially expressed RNAs in gastric cancer are mainly rich in neuroactive ligand–receptor interactions’ effect [ 52 ]; nicotine and tobacco addiction can increase risk [ 53 ]; there is increasing evidence that bacterial infection is also an important factor in inducing cancer [ 54 ]. GABA receptors are highly expressed in gastric cancer [ 55 ] and can enhance the proliferation ability of gastric cancer cells [ 56 ]. Additionally, we created a nomogram in this article to visually display five clinicopathological variables ( MAGEA11 , age, pathological stage, T/N stage).…”

Section: Discussionmentioning

confidence: 99%

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

et al. 2022

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Expression of MAGE family member A11 (MAGEA11) is upregulated in different tumors. However, in gastric cancer, the prognostic significance of MAGEA11 and its relationship with immune infiltration remain largely unknown. The expression of MAGEA11 in pan-cancer and the receiver operating characteristic (ROC) and survival impact of gastric cancer were evaluated by The Cancer Genome Atlas (TCGA). Whether MAGEA11 was an independent risk factor was assessed by Cox analysis. Nomograms were constructed from MAGEA11 and clinical variables. Gene functional pathway enrichment was obtained based on MAGEA11 differential analysis. The relationship between MAGEA11 and immune infiltration was determined by the Tumor Immunity Estimation Resource (TIMER) and the Tumor Immune System Interaction Database (TISIDB). Finally, MAGEA11-sensitive drugs were predicted based on the CellMiner database. The results showed that the expression of MAGEA11 mRNA in gastric cancer tissues was significantly higher than that in normal tissues. The ROC curve indicated an AUC value of 0.667. Survival analysis showed that patients with high MAGEA11 had poor prognosis (HR = 1.43, p = 0.034). In correlation analysis, MAGEA11 mRNA expression was found to be associated with tumor purity and immune invasion. Finally, drug sensitivity analysis found that the expression of MAGEA11 was correlated with seven drugs. Our study found that upregulated MAGEA11 in gastric cancer was significantly associated with lower survival and invasion by immune infiltration. It is suggested that MAGEA11 may be a potential biomarker and immunotherapy target for gastric cancer.

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Section: Discussionmentioning

confidence: 99%

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

et al. 2022

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“…Once a seizure is triggered, it is sustained by the activation of the NMDA receptor [59]. The seizures originate in the ventral forebrain, with the nucleus accumbens being the leading injury site due to its high concentration of muscarinic receptors [60]. EEG recordings have revealed a significant increase in spike activity in the hippocampus after the administration of pilocarpine.…”

Section: Pilocarpinementioning

confidence: 99%

“…Terminating seizure activity in pilocarpine is challenging unless repetitive doses or a combination of AEDs are used. These conditions result in a high mortality rate in animal models [60,62].…”

Section: Pilocarpinementioning

confidence: 99%

Diverse perspectives in zebrafish seizure models: An exploration of chemical inducers

Husnul Khotimah,

Fathina Zahrani Rahmaniar,

Fatimah Az Zahra

et al. 2024

World J. Adv. Res. Rev.

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Numerous studies have investigated seizures in zebrafish, employing diverse methods to induce and observe epilepsy. Chemical inducers have become indispensable tools for precisely manipulating neural activity in controlled experiments. This research is dedicated to a meticulous comparison and analysis of various seizure-inducing chemicals in zebrafish. The selected chemical inducers include pentylenetetrazole (PTZ), kainic acid (KA), picrotoxin (PTX), pilocarpine, and other substances. The primary mechanism of these inducers involves altering neurotransmitter receptors, particularly GABA and glutamate, at inhibitory or excitatory synapses. This alteration creates an imbalance between inhibitory and excitatory signals in the brain, contributing to epileptogenesis. The resulting hyperactivity in the zebrafish brain disrupts metabolism, elevates reactive oxygen species (ROS), and causes neuronal damage. Chemical induction offers valuable insights into the neurological activity of zebrafish, enabling the observation of behaviors such as whole-body contractions, loss of posture, or freezing. Various parameters can be adjusted to examine the effects of chemical inducers on zebrafish development and to replicate various types of seizures, such as status epilepticus and temporal lobe epilepsy. Despite the array of options available, many chemical inducers remain underutilized in zebrafish studies. To ensure the successful induction of models, monitoring gene expression markers such as c-fos, which represents neuronal activity, becomes crucial. Additionally, a scoring system is employed to analyze seizure severity and identify treatment efficacy. The existing gaps in utilizing chemical inducers present great opportunities for future model development. This chemically-induced seizure model in zebrafish is pivotal for unraveling seizure mechanisms, contributing significantly to advancements in neurological research.

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“…Brain metastasis involves cancer cell invasion, intravasation, and migration to brain cells by bypassing the blood-brain barrier (BBB) [41]. The RT-PCR study further revealed that the metastatic TNBC patients exhibited eight times higher GABRP expression than non-metastatic stage II-IV TNBC patients [42].…”

Section: Cd73mentioning

confidence: 99%

Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

Chaudhuri

Kumar

Deepa

et al. 2023

Cancers

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Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these cases turn out to be cases of triple-negative breast cancer (TNBC). TNBC is an aggressive and rare breast cancer subtype that accounts for 10–15% of all breast cancer cases. Chemotherapy remains the only therapy regimen against TNBC. However, the emergence of innate or acquired chemoresistance has hindered the chemotherapy used to treat TNBC. The data obtained from molecular technologies have recognized TNBC with various gene profiling and mutation settings that have helped establish and develop targeted therapies. New therapeutic strategies based on the targeted delivery of therapeutics have relied on the application of biomarkers derived from the molecular profiling of TNBC patients. Several biomarkers have been found that are targets for the precision therapy in TNBC, such as EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc. This review discusses the various candidate biomarkers identified in the treatment of TNBC along with the evidence supporting their use. It was established that nanoparticles had been considered a multifunctional system for delivering therapeutics to target sites with increased precision. Here, we also discuss the role of biomarkers in nanotechnology translation in TNBC therapy and management.

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The Emerging Roles of π Subunit-Containing GABA_A Receptors in Different Cancers

Cited by 8 publications

References 123 publications

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

Diverse perspectives in zebrafish seizure models: An exploration of chemical inducers

Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

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The Emerging Roles of π Subunit-Containing GABAA Receptors in Different Cancers

Cited by 8 publications

References 123 publications

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

Diverse perspectives in zebrafish seizure models: An exploration of chemical inducers

Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

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The Emerging Roles of π Subunit-Containing GABA_A Receptors in Different Cancers