MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration

Abstract

Expression of MAGE family member A11 (MAGEA11) is upregulated in different tumors. However, in gastric cancer, the prognostic significance of MAGEA11 and its relationship with immune infiltration remain largely unknown. The expression of MAGEA11 in pan-cancer and the receiver operating characteristic (ROC) and survival impact of gastric cancer were evaluated by The Cancer Genome Atlas (TCGA). Whether MAGEA11 was an independent risk factor was assessed by Cox analysis. Nomograms were constructed from MAGEA11 and clinical variables. Gene functional pathway enrichment was obtained based on MAGEA11 differential analysis. The relationship between MAGEA11 and immune infiltration was determined by the Tumor Immunity Estimation Resource (TIMER) and the Tumor Immune System Interaction Database (TISIDB). Finally, MAGEA11-sensitive drugs were predicted based on the CellMiner database. The results showed that the expression of MAGEA11 mRNA in gastric cancer tissues was significantly higher than that in normal tissues. The ROC curve indicated an AUC value of 0.667. Survival analysis showed that patients with high MAGEA11 had poor prognosis (HR = 1.43, p = 0.034). In correlation analysis, MAGEA11 mRNA expression was found to be associated with tumor purity and immune invasion. Finally, drug sensitivity analysis found that the expression of MAGEA11 was correlated with seven drugs. Our study found that upregulated MAGEA11 in gastric cancer was significantly associated with lower survival and invasion by immune infiltration. It is suggested that MAGEA11 may be a potential biomarker and immunotherapy target for gastric cancer.

Identification and Validation of a Cancer-Testis Antigen-Related Signature to Predict the Prognosis in Stomach Adenocarcinoma

“…Among the 11 CTA-related genes involved in the construction of CTARSig, MAGEA3 promotes the proliferation of GC cells and chemotherapy drug resistance [21] and is associated with lymph node metastasis and immune infiltration in GC [22]. In contrast, the upregulation of MAGEA11, a member of the MAGE family, in GC has been shown to be significantly associated with lower survival rates and immune infiltration, suggesting that MAGEA11 may be a potential biomarker and therapeutic target in GC [23]. THY1 is a risk factor for CTARSig, and previous studies have shown that patients with GC and high THY1 expression exhibit lower overall survival (OS) [24].…”