The emerging link between cancer, metabolism, and circadian rhythms

Masri, Selma; Sassone–Corsi, Paolo

doi:10.1038/s41591-018-0271-8

Cited by 303 publications

(253 citation statements)

References 134 publications

(180 reference statements)

Supporting

Mentioning

233

Contrasting

Unclassified

Order By: Relevance

“…HCC is the most common malignancy of primary liver cancers. Previous studies suggest the association of disruption of circadian rhythms with cancer development in various organs including the liver . Kettner et al generated Cry1 −/− Cry2 −/− mice, Per1 −/− Per2 −/− mice, and Alb ‐Cre‐mediated liver‐specific BMAL1 knockout mice and maintained them for 90 weeks .…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 99%

“…Previous studies suggest the association of disruption of circadian rhythms with cancer development in various organs including the liver. 77 Kettner et al generated Cry1 −/− Cry2 −/− mice, Per1 −/− Per2 −/− mice, and Alb-Cre-mediated liverspecific BMAL1 knockout mice and maintained them for 90 weeks. 78 These transgenic mice had lower survival rates with various disorders including neurodegeneration, cystic renal dysplasia, liver steatosis, and HCC compared to wildtype mice.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

See 1 more Smart Citation

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

View full text Add to dashboard Cite

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhythms and expressions as well as melatonin production. Previous studies indicate the association between circadian rhythms with various liver diseases, and disruption of rhythms or clock gene expression may promote liver steatosis, inflammation, or cancer development. It is well known that melatonin has strong antioxidant effects. Alcohol drinking or excess fatty acid accumulation produces reactive oxygen species and oxidative stress in the liver leading to liver injuries. Melatonin administration protects these oxidative stress‐induced liver damage and improves liver conditions. Recent studies have demonstrated that melatonin administration is not limited to antioxidant effects and it has various other effects contributing to the management of liver conditions. Accumulating evidence suggests that restoring circadian rhythms or expressions as well as melatonin supplementation may be promising therapeutic strategies for liver diseases. This review summarizes recent findings for the functional roles and therapeutic potentials of circadian rhythms and melatonin in liver diseases.

show abstract

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 99%

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

View full text Add to dashboard Cite

show abstract

“…This will be of great importance for breast cancer treatment and prevention if validated. The striking results obtained by Masri et al [29] and Masri and Sassone-Corsi [30] illustrated a previously unappreciated role played by lung adenocarcinoma as an endogenous circadian organizer in the rewiring of circadian homeostasis of the liver. Another important observation regarding the tumor macroenvironment and the biological clock in cancer was made by de Assis et al [31].…”

confidence: 88%

Tumor Macroenvironment: An Update

Al-Zoughbi¹,

Höefler²

2019

Pathobiology

View full text Add to dashboard Cite

Modes of tumor cell interaction include autocrine stimulation, secretion of paracrine growth factors and inhibitors, as well as interaction with the tumor macroenvironment. This evolving concept in tumor pathobiology describes the interaction of a malignant tumor with its host as an extension and addition to its local interaction with tumor cells and surrounding nontransformed cells, the tumor microenvironment. Angiogenesis, which is considered part of the tumor microenvironment, also allows reciprocal interactions between cancer cells and other organs and systems. Wellknown examples of tumor endocrine signaling are the paraneoplastic syndromes. In addition, cachexia, a severe complication of tumor growth, results from the systemic reprogramming of the host metabolism as a result of tumor growth and progression. Moreover, recent reports indicate that cancer cells may secrete factors that might play a role in forming premetastatic niches at distant sites. In addition, cancer cells seem to be able to secrete factors influencing and resetting endogenous circadian organizers. The importance of understanding the whole complex interaction of a malignant tumor and its host -the tumor macroenvironment -is of great importance for the better management and treatment of cancer patients.

show abstract

“…The circadian clock system ensures a temporal coordination of body physiology and metabolism via behavioural, neural and endocrine pathways ( Figure 1A,B). 1,5,7,[45][46][47][48][49][50][51][52][53] Peripheral oscillators operative in liver, skeletal muscle, adipose tissue, thyroid gland, endocrine pancreas and other organs regulate physiological functions within these organs, adjusting them on a daily basis to rest-activity and feeding-fasting cycles ( Figure 1B,C; Figure 2, left panel). 48,[54][55][56][57] Circadian oscillators exert their regulatory effects at several levels, from gene transcription to organ function.…”

Section: Of Mammalian Physiology and Metabolismmentioning

confidence: 99%

The importance of being rhythmic: Living in harmony with your body clocks

Dibner

2019

Acta Physiologica

View full text Add to dashboard Cite

OSCILLATORSThe time-keeping system, dubbed "circadian" from Latin circa diem (about a day), allows light-sensitive beings, including humans, to coordinate their physiology and behaviour to the daily changes in geophysical time (Figure 1). The mammalian network of body clocks is organized in a strictly hierarchical manner. A master oscillator, residing in the paired suprachiasmatic nuclei (SCN) of the hypothalamus ( Figure 1A), synchronizes a myriad of peripheral oscillators situated in each organ ( Figure 1B) on a daily basis. In turn, rhythmicity in the SCN is entrained by external timecues or Zeitgebers (German term for time givers). Daily changes in light intensity, detected by classical photoreceptors and intrinsically light-sensitive retinal ganglion cells expressing AbstractCircadian rhythms have developed in all light-sensitive organisms, including humans, as a fundamental anticipatory mechanism that enables proactive adaptation to environmental changes. The circadian system is organized in a highly hierarchical manner, with clocks operative in most cells of the body ensuring the temporal coordination of physiological processes. Circadian misalignment, stemming from modern life style, draws increasing attention due to its tight association with the development of metabolic, cardiovascular, inflammatory and mental diseases as well as cancer.This review highlights recent findings emphasizing the role of the circadian system in the temporal orchestration of physiology, with a particular focus on implications of circadian misalignment in human pathologies. K E Y W O R D Scircadian clock, circadian misalignment, continuous recording of circadian bioluminescence, human physiology How to cite this article: Dibner C. The importance of being rhythmic: Living in harmony with your body clocks. Acta Physiol. 2020;228:e13281. https ://doi.

show abstract

The emerging link between cancer, metabolism, and circadian rhythms

Cited by 303 publications

References 134 publications

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Tumor Macroenvironment: An Update

The importance of being rhythmic: Living in harmony with your body clocks

Contact Info

Product

Resources

About