The Embryo–Fetal Toxicity and Teratogenic Potential of Ammonium Perfluorooctanoate (APFO) in the Rat

Staples, Robert; Burgess, Bruce A.; Kerns, William

doi:10.1093/toxsci/4.3part1.429

Cited by 8 publications

(8 citation statements)

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“…Developmental and reproductive studies in rats fed PFOA have not demonstrated developmental defects in offspring (49) despite observed toxicity in parents. However rat pup body weight was significantly reduced during lactation from PFOA treated mothers.…”

Section: Discussionmentioning

confidence: 98%

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Emmett

Zhang

Shofer

et al. 2006

Journal of Occupational and Environmental Medicine

171

162

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Section: Discussionmentioning

confidence: 98%

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Emmett

Zhang

Shofer

et al. 2006

Journal of Occupational and Environmental Medicine

171

162

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“…No teratogenicity has been found in rats after administration of PFOA by inhalation (0, 0.1, 1, 10, and 25 mg/m³) or in the diet (100 mg/kg b.w. per day) between day 6 and 15 of pregnancy (Staples and Burgess, 1984). In rats, the NOAEL for maternal toxicity and developmental toxicity were 5 and 150 mg/kg b.w.…”

Section: Developmental and Reproductive Toxicitymentioning

confidence: 98%

Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts Scientific Opinion of the Panel on Contaminants in the Food chain

2008

EFS2

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Perfluoroalkylated substances (PFAS) is the collective name for a vast group of fluorinated compounds, including oligomers and polymers, which consist of neutral and anionic surface active compounds with high thermal, chemical and biological inertness. Perfluorinated compounds are generally hydrophobic but also lipophobic and will therefore not accumulate in fatty tissues as is usually the case with other persistent halogenated compounds. An important subset is the (per)fluorinated organic surfactants, to which perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) belong. The analytical detection method of choice for PFOS and PFOA is currently liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS), whereas both LC-1 For citation purposes: Opinion of the Scientific Panel on Contaminants in the Food chain on Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts,

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“…Thus far, only information pertaining to the rat and the rabbit is available. Teratological studies of PFOA have been conducted by Gortner (1981) with rats and rabbits (Gortner, 1982), and Staples et al (1984) with rats, but neither laboratory reported any significant findings with administered doses up to 100 -150 mg/kg/day for rats and 50 mg/ kg/day for rabbits.…”

Section: Toxicity Of Perfluorooctanoic Acidmentioning

confidence: 99%

The developmental toxicity of perfluoroalkyl acids and their derivatives

Lau

Butenhoff²,

Rogers

2004

Toxicology and Applied Pharmacology

764

480

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Perfluoroalkyl acids such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have applications in numerous industrial and consumer products. Although the toxicology of some of these compounds has been investigated in the past, the widespread prevalence of PFOS and PFOA in humans, as demonstrated in recent bio-monitoring studies, has drawn considerable interest from the public and regulatory agencies as well as renewed efforts to better understand the hazards that may be inherent in these compounds. This review provides a brief overview of the perfluoroalkyl chemicals and a summary of the available information on the developmental toxicity of the eight-carbon compounds, PFOS and PFOA. Although the teratological potentials of some of these chemicals had been studied in the past and the findings were generally unremarkable, results from recent postnatal studies on developmental and reproductive indices have prompted consideration of their relevance to human health risk. Based on current understanding of the developmental effects of PFOS and PFOA in rodents, several avenues of research are suggested that would further support the risk assessment of these perfluorinated organic chemicals.

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The Embryo–Fetal Toxicity and Teratogenic Potential of Ammonium Perfluorooctanoate (APFO) in the Rat

Cited by 8 publications

References 0 publications

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts Scientific Opinion of the Panel on Contaminants in the Food chain

The developmental toxicity of perfluoroalkyl acids and their derivatives

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