Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Emmett, Edward A.; Zhang, Hong; Shofer, Frances S.; Freeman, D.W.; Rodway, Nancy V.; Desai, Chintan S.; Shaw, Leslie M.

doi:10.1097/01.jom.0000233380.13087.37

Cited by 173 publications

(178 citation statements)

References 45 publications

(56 reference statements)

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“…As shown in Supplementary Table S3, previous studies have investigated the associations between serum lipids and PFAAs concentrations (Emmett et al, 2006;Sakr et al, 2007a;Sakr et al, 2007b;Frisbee et al, 2010a;Nelson et al, 2010;Eriksen et al, 2013;Fisher et al, 2013). However, those data are not always consistent.…”

Section: Discussionmentioning

confidence: 64%

“…In contrast, Olsen et al conducted a study among 506 fluorochemical production workers and showed no association between PFOA and TC or LDLC . Emmett et al (2006) assessed PFOA concentrations among 371 residents living around a DuPont plant and found no association between PFOA and TC. Results from Canadian Health Measures Survey exhibited an association between PFOA and TC in unweighted models, but this association became insignificant after weighting for sampling strategy (Fisher et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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a b s t r a c tPerfluoroalkyl acids (PFAAs) have been used in a variety of products for many years and have been detected worldwide in human serum. Previous studies have suggested the potential effects of PFAAs on serum lipids. To investigate the associations between serum concentrations of PFAAs and serum lipid levels, 133 participants were randomly selected from the people coming for health check-up in Yuanyang Red Cross Hospital of Henan, China. Linear regression analysis revealed that perfluoro-octanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA), with a median concentration of 1.43, 0.37, and 0.19 ng/mL, respectively, were positively associated with total cholesterol (TC). Those in the highest quartile of PFOA exposure had ln-TC levels 0.24 mmol/L higher than those in the lowest quartile. For PFNA and PFDA, effect estimates were 0.25 and 0.16 mmol/L, respectively. A positive association between high-density lipoprotein cholesterol (HDLC) and PFDA was found, and there was a 0.18 mmol/L increase of HDLC for the top PFDA quartile compared with the lowest quartile. PFOA and PFNA were positively associated with low-density lipoprotein cholesterol (LDLC). Ln-LDLC levels of people in both top PFOA and PFNA quartiles were 0.33 mmol/L higher than those in the lowest quartiles. Logistic regression analysis indicated that increased PFOA and PFOS quartiles were positively associated with an increased risk of abnormal TC and LDLC when controlling for no confounding factors.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Wang

Fu³

et al. 2014

Ecotoxicology and Environmental Safety

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“…Neither a worker population study (Kaplan 2004) nor a community-based PFOA-exposed population (Emmett et al 2006a, b) has reported associations between PFOA and hepatic clinical chemistries. In the Emmett et al (2006a) study, there was no relationship between the blood levels of PFOA and the results for cholesterol, hepatic-related tests (serum protein, albumin, bilirubin, serum alkaline phosphatase, AST, ALT and GGT), or being treated for or informed by a physician that a community participant had liver disease (cirrhosis, hepatitis, and any other liver condition).…”

Section: Discussionmentioning

confidence: 99%

“…In another occupational study, Kaplan (2004) did not report an association between HDL and serum PFOA concentrations. Neither did Emmett et al (2006a) in a community-based exposure study whose median PFOA concentrations (approximately 0.354 lg/ml) were 60 times higher than that of general population studies (Calafat et al 2006;Olsen et al 2003b). To further clarify any possible association with HDL, the A apolipoproteins, which form the major proteins found in HDL, could be measured although this was not part of the present study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Olsen

Zobel

2007

Int Arch Occup Environ Health

252

178

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Objectives Perfluorooctanoic acid (PFOA) results in peroxisome proliferator mediated effects in rats and mice resulting in hypolipidemia but not in monkeys. Counterintuitive modestly positive associations between PFOA and cholesterol levels in production workers have been inconsistently reported. The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities. Methods Subjects were male employee voluntary participants of a fluorochemical medical surveillance program who provided blood samples for serum measurement of PFOA (perfluorooctanoate) and various lipid, hepatic, and thyroid parameters. Statistical analyses included multiple and logistic regression and analysis of covariance. Results A total of 506 employees, who did not take cholesterol-lowering medications (93% of all male participants), were analyzed. Serum PFOA concentrations ranged from 0.007 to 92.03 lg/ml [arithmetic mean 2.21 lg/ml (95% confidence interval 1.66-2.77), median 1.10 lg/ml]. Adjusted for age, body mass index, and alcohol usage in regression analyses, PFOA was not statistically significantly (P > 0.05) associated with total cholesterol or low-density lipoproteins (LDL). High-density lipoproteins (HDL) were significantly negatively (P < 0.01) associated with PFOA for the three facilities combined but not by individual sites, indicating the overall result was likely a consequence of residual confounding due to different demographic profiles at these sites. Serum triglycerides were significantly positively associated with PFOA but not consistently by locations. There were no statistically significant associations observed between PFOA and hepatic enzymes for the three facilities combined although some modest positive associations were observed between PFOA and hepatic enzymes at one of the three facilities. Analyses of all locations showed no associations with TSH or T4 and PFOA. A negative association was observed for free T4 and positive association for T3; however, the findings were well within these assays' normal reference ranges. Conclusion There was no evidence that employees' serum PFOA concentrations were associated with total cholesterol or LDL. A negative association with HDL was explained by demographic differences across the three locations. Several explanations are offered for the inconsistent triglyceride associations with PFOA including both methodological as well as biological possibilities.

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“…[89][90][91] In some cases, water treatment using activated carbon has been shown to be effective for removing longer chain PFAs such as n-PFOA from contaminated source waters. [20,[54][55][56]70] PFAs, like their hydrocarbon fatty acid analogs, [92,93] also sorb to inorganic surfaces such as sands, clays, iron oxides, calcium fluoride, and surface modified silicas. [82,94,95] but organic matter sorption is thought to be dominant in most environmental systems and offer the most promising for treatment methods.…”

Section: Introductionmentioning

confidence: 99%

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluoroalkyl carboxylic and sulfonic acids

Rayne

Forest

2009

Nature Precedings

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Organic carbon normalized soil and sediment-water partitioning (K oc ) coefficients were estimated for all C 1 through C 8 perfluorinated alkylsulfonic acid (PFSA) and alkylcarboxylic acids (PFCA) congeners. The limited experimental K oc dataset for the straight chain C 7 through C 10 PFCAs and C 8 and increasing perfluoroalkyl chain length and linearity increase K oc values with substantial intra-and interhomologue variation and interhomologue mixing. Variability in K oc values among the PFCA and PFSA congeners will likely lead to an enrichment of more linear and longer chain isomers in organic matter fractions, resulting in aqueous phases fractionated towards shorter chain branched congeners. The expected magnitude of fractionation will require inclusion in source apportionment models and risk assessments. A comparison of representative established quantitative structure property relationships for estimated K oc values from octanol-water partitioning constants suggests that equilibrium partitioning frameworks may be applicable towards modeling PFCA and PFSA environmental fate processes and warrants further study using other partitioning coefficients for which suitable experimental data is available.

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Community Exposure to Perfluorooctanoate: Relationships Between Serum Levels and Certain Health Parameters

Abstract: No toxicity from PFOA was demonstrated using the measured end points; other end points need to be addressed.

Cited by 173 publications

References 45 publications

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Associations between serum concentrations of perfluoroalkyl acids and serum lipid levels in a Chinese population

Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluoroalkyl carboxylic and sulfonic acids

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