The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat

Staples, Robert; Burgess, Bruce A.; Kerns, William

doi:10.1016/0272-0590(84)90200-8

Cited by 27 publications

(6 citation statements)

References 7 publications

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“…Eleven gavage studies used water as a vehicle control and two used corn oil ( Table 3 ). The inhalation study utilized three control groups: in-house air only, in-house air pair-fed 10 mg/m 3 PFOA, and in-house air pair-fed 25 mg/m 3 PFOA ( Staples et al 1984 ). The PFOA-treated food study ( Onishchenko et al 2011 ) used ethanol-treated food as a control, and the PFOA-treated water study ( Hu et al 2010 ) used untreated water as a control.…”

Section: Resultsmentioning

confidence: 99%

“…Search methods. Our search was developed by analyzing the Medical Subject Headings (MeSH) and other terms from the title and abstract text of a group of seven papers known to us, judged to be relevant to our study question, and which represented different journals and years of publication ( Abbott et al 2007 ; Butenhoff et al 2004 ; Hines et al 2009 ; Lau et al 2006 ; Staples et al 1984 ; White et al 2007 , 2009 ). A list of common and unique terms was compiled and incorporated into a search strategy to address the exposure (PFOA) and outcomes of interest (reproductive/developmental toxicity), as defined in the PECO statement (see Supplemental Material, Tables S1, S2).…”

Section: Methodsmentioning

confidence: 99%

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The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth

Koustas

Lam

Sutton

et al. 2014

Environ Health Perspect

146

123

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Background: In contrast to current methods of expert-based narrative review, the Navigation Guide is a systematic and transparent method for synthesizing environmental health research from multiple evidence streams. The Navigation Guide was developed to effectively and efficiently translate the available scientific evidence into timely prevention-oriented action.Objectives: We applied the Navigation Guide systematic review method to answer the question “Does fetal developmental exposure to perfluorooctanoic acid (PFOA) or its salts affect fetal growth in animals ?” and to rate the strength of the experimental animal evidence.Methods: We conducted a comprehensive search of the literature, applied prespecified criteria to the search results to identify relevant studies, extracted data from studies, obtained additional information from study authors, conducted meta-analyses, and rated the overall quality and strength of the evidence.Results: Twenty-one studies met the inclusion criteria. From the meta-analysis of eight mouse gavage data sets, we estimated that exposure of pregnant mice to increasing concentrations of PFOA was associated with a change in mean pup birth weight of –0.023 g (95% CI: –0.029, –0.016) per 1-unit increase in dose (milligrams per kilogram body weight per day). The evidence, consisting of 15 mammalian and 6 nonmammalian studies, was rated as “moderate” and “low” quality, respectively.Conclusion: Based on this first application of the Navigation Guide methodology, we found sufficient evidence that fetal developmental exposure to PFOA reduces fetal growth in animals.Citation: Koustas E, Lam J, Sutton P, Johnson PI, Atchley DS, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. 2014. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environ Health Perspect 122:1015–1027; http://dx.doi.org/10.1289/ehp.1307177

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth

Koustas

Lam

Sutton

et al. 2014

Environ Health Perspect

146

123

View full text Add to dashboard Cite

show abstract

“…In contrast, no malformations were observed in the current developmental toxicity study at doses up to 500 mg kg À1 day À1 ; developmental toxicity was limited to a small fetal growth retardation at 500 mg kg À1 day À1 , a maternally toxic dose. In addition, no evidence of teratogenicity was observed with PFOA in rats, even at doses that produced maternal mortality (Staples et al, 1984).…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the Reproductive and Developmental Toxicity of a Fluoroalkylethanol Mixture

Mylchreest

Ladics

Munley

et al. 2005

Drug & Chem. Toxicology

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The objective of these studies was to evaluate the reproductive and developmental toxicity of a commercial fluoroalkylethanol mixture, which is an intermediate in the production of fluorotelomers. The test substance was administered daily by gavage to Sprague-Dawley rats as a suspension in 0.5% aqueous methylcellulose. In a one-generation reproductive toxicity study, rats (20 per sex per group) were given dosages of 0, 25, 100, or 250 mg kg(-1) day(-1) for a period of 74 days prior to cohabitation, and during mating, gestation, and lactation. Body weights, feed consumption, clinical signs, gross pathology, sperm parameters, estrous cyclicity, and reproductive performance were evaluated for the P1 generation. The F1 offspring were.evaluated during the lactation period for growth and survival and given a gross pathology examination at weaning. A subset of the offspring were retained; body weights, feed consumption, clinical signs, and age at onset of vaginal opening and preputial separation were evaluated, and gross pathology was performed on postnatal day 60. In the developmental toxicity study, groups of time-mated Sprague-Dawley female rats were given the test substance as a suspension in 0.5% aqueous methylcellulose at daily dosages of 0, 50, 200, or 500 mg kg(-1) day(-1) by gavage on gestation days 6-20. During the in-life portion of the study, growth parameters and clinical observations were made. On gestation day 21, dams were euthanized, and the thoracic and abdominal viscera were examined. The uterine contents were removed and examined, and fetuses were evaluated for any alterations. In the reproduction study, litter size at birth, number of live pups per litter on day 0 and 4 of lactation, and pup weights during lactation were reduced in groups administered > or =100 mg kg(-1) day(-1). No other reproductive parameters were affected. There were no adverse reproductive effects observed at 25 mg kg(-1) day(-1). In the developmental toxicity study, reduced maternal body weight parameters, increased perineal fur staining, and increased fetal skeletal alterations were observed at 500 mg kg(-1) day(-1). There was no maternal or developmental toxicity at 50 or 200 mg kg(-1) day(-1). Under the conditions of the studies, the no-observed adverse effect levels for this mixture were 25 mg kg(-1) day(-1) for subchronic toxicity and reproductive parameters and 200 mg kg(-1) day(-1) for developmental toxicity end points. No functional reproductive or developmental effects were observed at dose levels that did not adversely affect adult animals.

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“…First, experimental studies have been conducted that cover all periods of development and lifetime exposure in rats. These include the two cancer studies (Biegel et al, 2001;Sibinski et al, 1983), developmental toxicity studies in rats and rabbits (Gortner, 1981;Gortner, 1982;Staples et al, 1984), and the twogeneration reproduction study in rats . A second factor that addresses uncertainty related to chronic exposure is the availability of epidemiological and medical monitoring studies in exposed workers over several decades, where exposures on a serum PFOA concentration basis have been significantly higher than those of the general population (3M Company, 2003a,b;Alexander, 2001;Gilliland, 1992;Gilliland and Mandel, 1996;NIOSH, 2001;Olsen et al, 1998;Olsen et al, 2000;Olsen et al, 2003a;Ubel et al, 1980).…”

Section: Factors Reducing Uncertainty Related To Chronicity Of Exposurementioning

confidence: 98%

Characterization of risk for general population exposure to perfluorooctanoate

Butenhoff

Gaylor²,

Moore³

et al. 2004

Regulatory Toxicology and Pharmacology

127

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The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat

Cited by 27 publications

References 7 publications

The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth

The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth

Evaluation of the Reproductive and Developmental Toxicity of a Fluoroalkylethanol Mixture

Characterization of risk for general population exposure to perfluorooctanoate

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