The embrace Device Significantly Decreases Scarring following Scar Revision Surgery in a Randomized Controlled Trial

Lim, Agnes; Weintraub, Jennifer; Kaplan, Ernest N.; Januszyk, Michael; Cowley, Christy; McLaughlin, Peggy; Beasley, Bill; Gurtner, Geoffrey C.; Longaker, Michael T.

doi:10.1097/01.prs.0000436526.64046.d0

Cited by 84 publications

(61 citation statements)

References 15 publications

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“…By knocking out or inhibiting various components of the inflammatory FAK-ERK-MCP-1 pathway, scar formation was attenuated. (Wong, et al, 2012) This work has translated to the development of a stress-shielding device that has been shown in two randomized controlled clinical trials to reduce scar formation (Lim, et al, 2014, Longaker, et al, 2014). Early gestational cells may also modify their embryonic niche in a way that promotes regenerative healing, while the cells of late gestation may be restricted to reparative healing.…”

Section: Scarless Wound Healing As It Occurs In Naturementioning

confidence: 99%

Scarless wound healing: finding the right cells and signals

et al. 2016

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From the moment we are born, every injury to the skin has the potential to form a scar, many of which can impair form and/or function. As such, scar management constitutes a billion-dollar industry. Yet effectively promoting scarless wound healing remains an elusive goal. The complex interactions of wound healing contribute to our inability to recapitulate scarless wound repair as it occurs in nature, such as in fetal skin and oral mucosa. However, many new advances have occurred over recent years, some of which have translated scientific findings from bench to bedside. In vivo lineage tracing has helped establish a variety of novel cellular culprits that may act as key drivers of the fibrotic response. These newly characterized cell populations present further targets for therapeutic intervention, some of which have already demonstrated promising results in animal models. Here, we discuss several recent studies that identify exciting approaches to diminishing scar formation (Fig. 1). Particular attention will also be paid to the canonical Wnt/β-catenin signaling pathway, which plays an important role in both embryogenesis and tissue repair. New insights into the differential effects of Wnt signaling on heterogeneous fibroblast and keratinocyte populations within the skin further demonstrate methods by which wound healing can be redirected to a more fetal, scarless phenotype.

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Section: Scarless Wound Healing As It Occurs In Naturementioning

confidence: 99%

Scarless wound healing: finding the right cells and signals

et al. 2016

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“…67 Silicone sheeting treatment is reported to soften, increase elasticity, and improve the appearance of HSc, 68 but conflicting results remain in the literature, which may be attributed to patient compliance. 69 The proposed mechanisms of action include increased oxygen delivery to the epidermis and dermis, hydration of the stratum corneum, surface skin temperature, and reduced tissue turgor.…”

Section: Basic Science Of Scarsmentioning

confidence: 99%

“…65–67,69,70 Meta-analysis of the benefits of silicone gel sheets suggests further research is required for high-level evidence of their benefit for HSc, despite ongoing encouraging trials. 68–70 …”

Section: Basic Science Of Scarsmentioning

confidence: 99%

Biology and Principles of Scar Management and Burn Reconstruction

Tredget

Lévi

Donelan

2014

Surgical Clinics of North America

112

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“…The Embrace device significantly improved scar appearance ( p < 0.005), and 100% of patients were either ''satisfied'' or ''very satisfied'' with the minimized scarring. 112 …”

Section: 108mentioning

confidence: 99%

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

Barnes

Marshall

Leavitt

et al. 2018

Advances in Wound Care

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163

131

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Significance: Excessive scarring is major clinical and financial burden in the United States. Improved therapies are necessary to reduce scarring, especially in patients affected by hypertrophic and keloid scars. Recent Advances: Advances in our understanding of mechanical forces in the wound environment enable us to target mechanical forces to minimize scar formation. Fetal wounds experience much lower resting stress when compared with adult wounds, and they heal without scars. Therapies that modulate mechanical forces in the wound environment are able to reduce scar size. Critical Issues: Increased mechanical stresses in the wound environment induce hypertrophic scarring via activation of mechanotransduction pathways. Mechanical stimulation modulates integrin, Wingless-type, protein kinase B, and focal adhesion kinase, resulting in cell proliferation and, ultimately, fibrosis. Therefore, the development of therapies that reduce mechanical forces in the wound environment would decrease the risk of developing excessive scars. Future Directions: The development of novel mechanotherapies is necessary to minimize scar formation and advance adult wound healing toward the scarless ideal. Mechanotransduction pathways are potential targets to reduce excessive scar formation, and thus, continued studies on therapies that utilize mechanical offloading and mechanomodulation are needed.

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The embrace Device Significantly Decreases Scarring following Scar Revision Surgery in a Randomized Controlled Trial

Cited by 84 publications

References 15 publications

Scarless wound healing: finding the right cells and signals

Scarless wound healing: finding the right cells and signals

Biology and Principles of Scar Management and Burn Reconstruction

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

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