The elusive dermatofibromas

Sanchez, R. L.

doi:10.1001/archderm.126.4.522

Cited by 8 publications

(2 citation statements)

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“…The striking similarity to cellular neurothekeoma has already been stressed by Requena and Sangü eza in 1995 34 . Both entities only differ (a) by the predominantly subcutaneous location of plexiform fibrohistiocytic tumour, although a dermal variant of plexiform fibrohistiocytic tumour was recently described 15 ; and (b) by the greater prominence of (osteoclast-like) giant cells in plexiform fibrohistiocytic tumour which may also be seen in various subtypes of dermatofibroma such as pseudosarcomatous 41 , elusive 42 and aneurysmal (fibrous) histiocytomas 43 . Thus, the idea that plexiform fibrohistiocytic tumour could also be a variant of dermatofibroma is intriguing.…”

Section: Discussionmentioning

confidence: 99%

Cellular ‘neurothekeoma’: an epithelioid variant of dermatofibroma?

Zelger¹,

Steiner²,

Kutzner

et al. 1998

Histopathology

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The appearance of dermatofibromas is markedly influenced by architectural, e.g. in deep penetrating dermatofibroma, and/or cellular/stromal criteria, e.g. in epithelioid cell histiocytoma or sclerosing dermatofibroma. Cellular neurothekeoma seems to be a variant of dermatofibromas with both architectural and cellular/stromal peculiarities, i.e. plexiform pattern, epithelioid cytology and stromal sclerosis.

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Section: Discussionmentioning

confidence: 99%

Cellular ‘neurothekeoma’: an epithelioid variant of dermatofibroma?

Zelger¹,

Steiner²,

Kutzner

et al. 1998

Histopathology

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“…These are persistent lesions and undergo very minimal change along the course of many years[ 5 ] and this is the reason why fully evolved dermatofibromas are rarely excised unless asked for by the patient.…”

Section: Discussionmentioning

confidence: 99%

Multiple eruptive dermatofibromas masquerading as cutaneous lymphoma

2016

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A 34-year-old male came with complaints of multiple firms to hard nontender, nonitchy nodules, measuring 2 cm × 2 cm to 1 cm × 1.5 cm, present predominantly over the lower limbs. This condition started 5 years back as a single nodule over the thigh but gradually increased in number and size with time to involve both lower limbs. A differential diagnosis of cutaneous lymphoma and dermatofibroma was considered. He underwent a biopsy and immunohistochemistry for the same which were consistent with hemosiderotic histiocytoma and positive for vimentin. The patient was advised surgical excision for the same. The occurrence of multiple dermatofibromas although rare has been reported in a few case reports; however, the occurrence of multiple dermatofibromas of the hemosiderotic variant has not been documented yet.

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Non-Langerhans Cell Histiocytoses

Zelger

Sidoroff

Orchard

et al. 1996

The American Journal of Dermatopathology

221

197

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Based on our series of 111 cases of non-Langerhans cell histiocytoses, we present a new unifying concept for this rare group of disorders. The common denominator is the monocyte/ macrophage, which presents with various histologic features probably due to the influence of cytokines. Non-Langerhans cell histiocytoses are classified according to the predominant mononuclear (vacuolated, spindle-shaped, xanthomatized, scalloped, and oncocytic) and/or multinucleate (Touton, ground-glass appearance, Langhans, and foreign body) histiocytic cell types. Variable mixtures of these cell types produce common polymorphous patterns with prominence of vacuolated, spindle-shaped, and xanthomatized histiocytes in juvenile xanthogranulomas and of scalloped and oncocytic histiocytes in adult xanthogranulomas. Rarely, unusual monomorphous reaction patterns are observed: mostly vacuolated histiocytes are seen in the mononuclear variant of xanthogranulomas, (early benign cephalic histiocytosis, and generalized eruptive histiocytoma. Xanthomatized histiocytes predominate papular xanthoma and rarely xanthoma disseminatum, whereas spindle-shaped histiocytes are evident in spindle cell xanthogranuloma and progressive nodular histiocytosis, scalloped histiocytes are evident in most cases of xanthoma disseminatum, and finally oncocytic histiocytes are evident in reticulohistiocytoma and multicentric histiocytosis. Immunohistochemical, ultrastructural, and clinical findings can rationally be adjusted to this unifying concept of non-Langerhans cell histiocytoses. The time course of lesions, the age of the patients, and the presence or absence of underlying internal diseases are, or may, at least partially, be related to and thus explain variations on the theme of the non-Langerhans cell histiocytic reaction.

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The elusive dermatofibromas

Cited by 8 publications

References 0 publications

Cellular ‘neurothekeoma’: an epithelioid variant of dermatofibroma?

Cellular ‘neurothekeoma’: an epithelioid variant of dermatofibroma?

Multiple eruptive dermatofibromas masquerading as cutaneous lymphoma

Non-Langerhans Cell Histiocytoses

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