Multiple eruptive dermatofibromas masquerading as cutaneous lymphoma

Monteiro, Rowan; Aithal, Vijay; Tirumalae, Rajalakshmi

doi:10.4103/0019-5154.190131

Cited by 3 publications

(7 citation statements)

References 15 publications

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“…Full‐texts of 11 articles were not accessible and 30 articles were irrelevant after assessing the full‐text. Eventually, 96 studies fulfilled the eligibility criteria and were included [1–96] (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Comorbid diseases: The most common associations: Among 41, 45, and 18 patients with multiple DFs, MEDFs, and MCDFs, seven cases (17.1 %) [7][8][9][10][11][12][13], four cases (17.1 %) [14][15][16][17], and twelve cases (66.7 %), respectively, [1,[18][19][20][21][22][23][24][25][26][27][28] had no other diseases. The percentage of MCDF patients with no associated disease was significantly higher than in the other groups (Pearson Chi-square = 25.917, P < 0.001).…”

Section: Multiple Multiple Eruptive (Medfs) and Multiple Clustered De...mentioning

confidence: 99%

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Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

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Summary Multiple dermatofibromas (DFs) are rare benign fibrohistiocytic lesions characterized by asymptomatic hyperpigmented nodules. Several diseases, like systemic lupus erythematosus (SLE) and human immunodeficiency virus (HIV) infection, are found to be associated with multiple DFs. Here, we designed a systematic review by an electronic search of PubMed and Embase databases to select case reports of multiple DFs (29 May 2021). From 2,145 initially found articles, 96 studies (106 cases) were included. We classified multiple DFs (>1 DF lesion) into four subtypes and separately investigated clinical characteristics of each one: multiple eruptive DFs (MEDFs) (n = 45), multiple (n = 41), multiple clustered DFs (MCDFs) (n = 18), and giant combined (n = 2). The patients’ mean age was 38.3 ± 14.7 years. The majority were female (61.3 %). The lesions were commonly on the trunk and extremities (36.8 %). MEDFs (n = 36) had the most rapid disease onset (2.0 ± 6.6 years). Immunosuppression induced by either HIV (10.3 %) and hematologic malignancy (9.4 %) or immunosuppressive drugs (23.4 %) along with SLE (19.8 %) were the most observed associations. However, 66.7 % of the MCDF patients were otherwise healthy individuals. As for disease management, surgery and follow‐up were the preferred options. Most of the cases showed neither resolution nor development of new lesions in follow‐up.

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Section: Resultsmentioning

confidence: 99%

Section: Multiple Multiple Eruptive (Medfs) and Multiple Clustered De...mentioning

confidence: 99%

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

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“…"Collagen wrapping" is frequently seen, particularly at the periphery of DFs, in which spindle cells encircle collagen bundles [7], [21]. Since DF is a superficial form of benign fibrous histiocytoma, it is composed of a mixture of fibroblastic and histiocytic cells and on IHC [22]. Immunohistochemical staining may also be used to differentiate DFs from dermatofibrosarcoma protuberans [13].…”

Section: Discussionmentioning

confidence: 99%

Hyperpigmented Nodular Dermatofibroma: Two Cases Report and Brief Literature Review

Hardianty

Djawad

Wahab

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Dermatofibroma (DF) is a common benign skin tumor (Benign Fibrous Histiocytoma) that mostly affects the extremities with a tendency to occur more often in older females than males. It usually presents as a slow growing small brown dome shape papule on the extremities. DF has a chronic nature and can sometimes regresses spontaneously. Dermoscopy is essential in the evaluation of DF to help differentiate it with other skin tumors. The gold standard evaluation for diagnosis of DF is biopsy with histopathologic examination. Removal of DF is often due to cosmetic factors, with surgical excision being the preferred method for removal. DF has an excellent prognosis. CASE REPORT: We present two case reports of women with hyperpigmented nodules on the lower extremity. Dimple sign was positive. From dermoscopic study showed a pigment network and central white patch pattern. On histologic examination revealed proliferation of fibroblast such as spindle cells as a storiform pattern and hyperplastic epidermis with hyperpigmentation of the basal layer. Based on clinical features, dermoscopy and histopathological evaluation, the diagnosis of DF was established. Both patients were perform surgically excision and have a good result. CONCLUSION: Dermatofibroma is benign fibrous histiocytoma that represents one of the most common skin tumours. Nodular hyperpigmented dermatofibroma is a clinical variant of Dermatofibroma which can be treated with surgical excision with good prognosis.

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“…Die Volltexte von 11 Artikeln waren nicht zugänglich und 30 Artikel stellten sich nach Lesen des Volltexts als irrelevant heraus. Schließlich erfüllten 96 Studien die Eignungskriterien und wurden eingeschlossen [1–96] (Abbildung 1).…”

Section: Ergebnisseunclassified

“…Komorbidität: Die häufigsten Assoziationen: sieben der 41 (17,1 %) Patienten mit multiplen DF [7-13], vier der 45 (8,9 %) MEDF-Patienten [14][15][16][17] und zwölf der 18 (66,7 %) MCDF-Patienten [1, [18][19][20][21][22][23][24][25][26][27][28] hatten keine anderen Erkrankungen. Der Anteil der MCDF-Patienten ohne assoziierte Erkrankung war signifikant höher als bei den anderen Gruppen (Pearson Chi-Quadrat = 25,917, P < 0,001).…”

Section: Multiple Multiple Eruptive Und Multiple Gruppierte Dermatofi...unclassified

Klinische und histologische Charakteristika bei multiplen Dermatofibromen: Eine systematische Übersicht

Seifi

Kalantari

Etesami

2022

J Deutsche Derma Gesell

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Zusammenfassung Multiple Dermatofibrome (DF) sind seltene gutartige fibrohistiozytäre Läsionen, die durch asymptomatische hyperpigmentierte Knoten charakterisiert sind. Mehrere Erkrankungen wie systemischer Lupus erythematodes (SLE) und Infektionen mit dem humanen Immundefizienz‐Virus (HIV) sind mit multiplen DF assoziiert. Hier haben wir eine systematische Übersicht anhand einer elektronischen Recherche der Datenbanken PubMed und Embase konzipiert, um Fallberichte zu multiplen DF auszuwählen (29. Mai 2021). Von den 2145 ursprünglich gefundenen Artikeln wurden 96 Studien (106 Fälle) eingeschlossen. Multiple DF (> 1 DF‐Läsion) wurden in vier Subtypen eingeteilt und für jeden Subtyp wurden die klinischen Charakteristika separat untersucht: multiple eruptive DF (MEDF) (n = 45), multiple DF (n = 41), multiple gruppierte DF (MCDF) (n = 18) und große kombinierte DF (n = 2). Das Durchschnittsalter der Patienten betrug 38,3 ± 14,7 Jahre. Die Mehrzahl waren Frauen (61,3 %). Die Läsionen befanden sich häufig am Stamm und an den Extremitäten (36,8 %). MEDF (n = 36) hatten den schnellsten Krankheitsbeginn (2,0 ± 6,6 Jahre). Neben SLE (19,8 %) war eine durch HIV (10,3 %), maligne hämatologische Erkrankungen (9,4 %) oder Immunsuppressiva (23,4 %) induzierte Immunsuppression die am häufigsten beobachtete Assoziation. Allerdings waren 66,7 % der MCDF‐Patienten ansonsten gesund. Hinsichtlich des Managements der Erkrankung waren Operation und Nachkontrolle die bevorzugten Optionen. Bei den meisten Fällen trat während der Nachkontrolle weder eine Abheilung noch eine Entwicklung neuer Läsionen auf.

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Multiple eruptive dermatofibromas masquerading as cutaneous lymphoma

Cited by 3 publications

References 15 publications

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review

Hyperpigmented Nodular Dermatofibroma: Two Cases Report and Brief Literature Review

Klinische und histologische Charakteristika bei multiplen Dermatofibromen: Eine systematische Übersicht

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