The electroretinogram in normal and light-deprived rabbits

Reuter, J.H.; Legein, C. P. J. J. M. M.; Mark, F. Van Der; Hof, M.W. Van

doi:10.1007/bf00142531

Cited by 6 publications

(2 citation statements)

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“…Consistent with our observations, the response obtained by scotopic electroretinogram (ERG) studies in neonatal rabbits shows that the development of scotopic vision only achieves full maturation at 4-5 weeks after eye opening (Reuter et al, 1971;Gorfinkel et al, 1988). Specifically, the ERG b-wave appears at P11 (Reuter et al, 1971), while ERG oscillatory potentials, which represent the light-driven activities of inner retinal neurons, are not detectable until after the first two postnatal weeks (Gorfinkel et al, 1988). These findings suggest that the functional development of the primary rod pathway via AII-ON CB gap junction coupling begins after eye opening, possibly in the third postnatal week, as we found that rabbit AII ACs showed adult-like gap junction coupling patterns in P21-22 retinas (Fig.…”

Section: Development Of the Rod Photoreceptor Signaling Pathwayssupporting

confidence: 89%

Cx36 expression in the AII‐mediated rod pathway is activity dependent in the developing rabbit retina

Chiao

2015

Developmental Neurobiology

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Gap junctions are composed of connexin 36 (Cx36) and play a critical role in the rod photoreceptor signaling pathways of the vertebrate retina. Despite the fact that their connection and modulation in various rod pathways have been extensively studied in adult animals, little is known about the contribution and regulation of gap junctions to the development of the AII amacrine cell (AC)-mediated rod pathway. Using immunohistochemistry and microinjection, this study demonstrates a steady increase in relative Cx36 protein expression in both plexiform layers of the rabbit retina at around the time of eye opening. However, immediately after eye opening, most Cx36 immunoreactive AII ACs show no gap junction coupling pattern to neighboring cells and it is not until the third postnatal week that AII cells begin to exhibit an adult-like tracer-coupling pattern. Moreover, studies using dark-rearing and AMPA receptor blockade during postnatal development both revealed that relative levels of Cx36 immunoreactivity in AII ACs were increased when neural activity was inhibited. Our findings suggest that Cx36 expression in the AII-mediated rod pathway is activity dependent in the developing rabbit retina.

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