The electrochemical quantitation method for sugammadex via a molecularly imprinted polymer-based sensor

Abstract

Sugammadex (SUG) is a synthetically modified γ-cyclodextrin derivative used in hospitals after surgeries to reverse the neuromuscular blockade induced by rocuronium or vecuronium.

Development of highly selective and sensitive molecularly imprinted polymer-based electrochemical sensors for tolvaptan assay in tablets and serum

“…The calibration equation of the 4-AP-TOL-MIP(PP)/GCE sensor was obtained as Δ I (μA) = 9.44 × 10 11 (μA M −1 ) × C (M) + 58.62 (μA) ( r = 0.998) (Table 2). The LOD and LOQ values were calculated using the formulas 3 × s / m and 10 × s / m ( s : standard deviation, m : slope) 20,21 and were found to be 2.89 × 10 −12 and 9.62 × 10 −12 M, respectively.…”

“…The development of molecularly imprinted polymer (MIP)-based electrochemical sensors is rapidly emerging as a new technology for performing selective and sensitive assays of target compounds in various fields such as drug testing, food analysis, environmental monitoring, and clinical diagnostics. 20,21 MIPs can selectively detect a template molecule easily and quickly. 22,23 The synthesis procedure is simple and inexpensive, and MIPs are stable under harsh conditions.…”