The Eggshell of Insects: Differentiation-Specific Proteins and the Control of Their Synthesis and Accumulation During Development

Kafatos, Fotis C.; Regier, Jerome C.; Mazur, Grace Dane; Nadel, Marion R.; Blau, Helen M.; Petri, William H.; Wyman, Arlene R.; Gelinas, Richard; Moore, Pamela B.; Paul, Miles; Efstratiadis, Argiris; Vournakis, John N.; Goldsmith, Marian R.; Hunsley, James R.; Baker, Brendon M.; Nardi, James B.; Koehler, Martina

doi:10.1007/978-3-540-37332-2_2

Cited by 99 publications

(113 citation statements)

References 113 publications

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“…More speci¢cally, in Bombyx there is a large uptake of water by the oocyte in a short period just prior to choriogenesis [1] and this may require the formation of a robust VM by the follicular epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Oogenesis in the domesticated silkworm (Bombyx mori) is characterized by the asynchronous development of follicles resulting in the formation of linear arrays (ovarioles) of progressively maturing follicles [1]. Each follicle is a functional developing unit consisting of three cell types: one oocyte, an anterior cap-forming cluster of seven nurse cells of germ cell origin, and a surrounding monolayer of approximately 5000 epithelial (follicular) cells of mesodermal origin [2].…”

Section: Introductionmentioning

confidence: 99%

“…Each follicle is a functional developing unit consisting of three cell types: one oocyte, an anterior cap-forming cluster of seven nurse cells of germ cell origin, and a surrounding monolayer of approximately 5000 epithelial (follicular) cells of mesodermal origin [2]. The follicular epithelium can be viewed as an exocrine gland programmed to secrete unidirectionally (toward the oocyte) the eggshell components, vitelline membrane (VM) and chorion [1,3]. As follicles mature, they move through the ovarioles and undergo successively vitellogenesis (yolk uptake) and choriogenesis (eggshell formation).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to vertebrates in which the VM is secreted by the oocyte [7], in insects such as Drosophila and Bombyx, VM proteins (VMPs) are synthesized by and secreted from the cells of the follicular epithelium [1,8]. In the silkworm, the secretion of electron dense material at the follicular cell^oo-cyte interface at day 3 of pharate-adult development marks the initial stage of VM formation [2].…”

Section: Introductionmentioning

confidence: 99%

“…During vitellogenesis, this membrane thickens as electron dense material is added. When the VM approaches its ¢nal thickness, layers of overlapping protein plates (chorion) stack on top of it forming a water barrier that shields the oocyte from dehydration [1].…”

Section: Introductionmentioning

confidence: 99%

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An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

2002

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We have cloned and functionally characterized a novel protein, BmVMP30, which is synthesized by the cells of the follicular epithelium of the ovarian follicles of the domesticated silkworm Bombyx mori, secreted from them and associated with the vitelline membrane. BmVMP30 is a 30 kDa protein that bears limited structural features reminiscent of other insect vitelline membrane proteins. Although BmVMP30 does not share pronounced similarities or signature motifs with other reported proteins, its temporal and spatial expression and its behavior throughout oogenesis suggest that it is a novel member of the insect vitelline membrane protein family. The protein is expressed exclusively in the cells of the follicular epithelium during stages 3 315 to 3 31 of vitellogenesis, secreted from them and, ultimately, localized at the junction between the oocyte and the eggshell, where the vitelline membrane is located. Treatment of follicles with an antisense oligonucleotide that encompasses the translation initiation codon results in the production of an N-terminally truncated protein and disruption of the integrity of the follicular epithelium. Antisense oligonucleotide treatment, however, has no e¡ect on the implementation of the developmental program that directs the autonomous progression of ovarian follicles through the last stages of vitellogenesis and choriogenesis. ß

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

2002

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Pertussis toxin-sensitive G protein that supports vitellogenin uptake by promoting patency

Wang

Telfer

1998

Arch. Insect Biochem. Physiol.

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Regulation of cockroach oothecin synthesis by juvenile hormone

Pau

Weaver

Edwards‐Jones

1986

Arch. Insect Biochem. Physiol.

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Control of specific protein synthesis by juvenile hormone during sexual maturation and reproduction is being studied in t h e left colleterial gland of t h e cockroach Periplaneta arnericana. Rates of specific oothecin synthesis and oothecin mRNA concentrations have been measured during sexual maturation and t h e effects of allatectomy and administration of juvenile hormone determined. The heterogeneity of t h e oothecins has been characterized and found t o b e d u e probably t o a multiplicity of structural genes. The complete primary structure of t h e major oothecin has been deduced from t h e sequences of cloned cDNAS. It can b e divided into a central region and two flanking arms that share sequence features. The structures of t h e oothecins show strong homologies with t h e silkmoth chorion proteins.

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The Eggshell of Insects: Differentiation-Specific Proteins and the Control of Their Synthesis and Accumulation During Development

Cited by 99 publications

References 113 publications

An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

An ovarian follicular epithelium protein of the silkworm (Bombyx mori) that associates with the vitelline membrane and contributes to the structural integrity of the follicle

Pertussis toxin-sensitive G protein that supports vitellogenin uptake by promoting patency

Regulation of cockroach oothecin synthesis by juvenile hormone

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