The EGF and FGF Receptors Mediate Neuroglian Function to Control Growth Cone Decisions during Sensory Axon Guidance in Drosophila

García‐Alonso, Luis; Romani, Susana; Jiménez, Fernando

doi:10.1016/s0896-6273(00)00150-1

Cited by 72 publications

(83 citation statements)

References 43 publications

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“…Moreover, these findings are consistent with known features of the L1 family of cell adhesion molecules (CAMs), with which Ed protein shares extensive homology in its extracellular portion (Bai et al, 2001). L1 CAMs are involved in the control of axon outgrowth, where they are associated with regulation of Fgfr and Egfr activity (Williams et al, 1994;Schaefer et al, 1999;Kamiguchi and Lemmon, 2000;Garcia-Alonso et al, 2000). In brain extracts, L1 physically associates with the MAPK cascade components Raf1 and Erk2, while in vitro Erk2 can phosphorylate the L1 cytoplasmic domain (Schaefer et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

2003

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EGF receptor signalling plays diverse inductive roles during development. To achieve this, its activity must be carefully regulated in a variety of ways to control the time, pattern, intensity and duration of signalling. We show that the cell surface protein Echinoid is required to moderate Egfr signalling during R8 photoreceptor selection by the proneural gene atonal during Drosophila eye development. In echinoid mutants, Egfr signalling is increased during R8 formation, and this causes isolated R8 cells to be replaced by groups of two or three cells. This mutant phenotype resembles the normal inductive function of Egfr in other developmental contexts, particularly during atonalcontrolled neural recruitment of chordotonal sense organ precursors. We suggest that echinoid acts to prevent a similar inductive outcome of Egfr signalling during R8 selection.

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Section: Discussionmentioning

confidence: 99%

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

2003

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“…Neuronal expression of Nrg rescues the mutant phenotype suggesting that Nrg mediates heterophilic adhesion of the advancing axons with their substrate (Martin et al 2008). In the adult ocellar sensory system, Nrg establishes two distinct axonal pathways, one originating from the bristle mechanoreceptors and the other originating from the ocellar pioneer neurons (Garcia-Alonso et al 2000;Kristiansen et al 2005). Especially in the ocellar pioneer neurons, Nrg functions redundantly with Fas II.…”

Section: L1-cammentioning

confidence: 99%

Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

Γιαγτζόγλου¹,

Ly²,

Bellen³

2009

Cold Spring Harbor Perspectives in Biology

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“…In Drosophila, the FGFR heartless is required for neurogenesis, functioning in both glia migration and morphogenesis as a downstream mediator of Neuroglian cell-adhesion molecules (Forni et al 2004;Garcia-Alonso et al 2000). In C. elegans, FGF signaling affects axon outgrowth via egl-15 (Bulow et al 2004).…”

Section: Conserved Roles Of Fgf Signalingmentioning

confidence: 99%

FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

2007

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The fibroblast growth factor (FGF) signal transduction pathway serves as one of the key regulators of early metazoan development, displaying conserved roles in the specification of endodermal, mesodermal, and neural fates during vertebrate development. FGF signals also regulate gastrulation, in part, by triggering epithelial to mesenchymal transitions in embryos of both vertebrates and invertebrates. Thus, FGF signals coordinate gastrulation movements across many different phyla. To help understand the breadth of FGF signaling deployment across the animal kingdom, we have examined the presence and expression of genes encoding FGF pathway components in the anthozoan cnidarian Nematostella vectensis. We isolated three FGF ligands (NvFGF8A, NvFGF8B, and NvFGF1A), two FGF receptors (NvFGFRa and NvFGFRb), and two orthologs of vertebrate FGF responsive genes, Sprouty (NvSprouty), an inhibitor of FGF signaling, and Churchill (NvChurchill), a Zn finger transcription factor. We found these FGF ligands, receptors, and response gene expressed asymmetrically along the oral/aboral axis during gastrulation and in a developing chemosensory structure of planula stages known as the apical tuft. These results suggest a conserved role for FGF signaling molecules in coordinating both gastrulation and neural induction that predates the Cambrian explosion and the origins of the Bilateria.

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The EGF and FGF Receptors Mediate Neuroglian Function to Control Growth Cone Decisions during Sensory Axon Guidance in Drosophila

Cited by 72 publications

References 43 publications

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

Cell Adhesion, the Backbone of the Synapse: "Vertebrate" and "Invertebrate" Perspectives

FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian

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