The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

Crespo, Javier; Bouza, José Marı́a Eiros; Bravo, Antonio Javier Blasco; Mercado, Pablo Lázaro de; Guirao, Antonio Aguilera; García, Féderico; García-Samaniego, Javier; Calleja, José Luís

doi:10.17235/reed.2018.5810/2018

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…17 Different strategies are being developed to simplify the screening process and improve diagnosis rates. These include one-step diagnostic schemes, 26 the creation of active search programmes for patients with positive serology, and alert programmes for primary care physicians when a positive serology exists for hepatitis C. The implementation of universal screening has been widely debated, 27 although most of the projects currently underway focus on the micro-elimination of the epidemic in at-risk population groups, such as intravenous drug users, inmates or men who have sex with men who engage in at-risk practices. 28 Our study shows the importance of establishing HCV and HIV elimination programmes in the general population, since a high percentage is not currently included in high-risk groups, being the greatest opportunity for diagnosis in primary care.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C and HIV combined screening in primary care: A cluster randomized trial

Martínez-Sanz

Vivancos

Sánchez-Conde

et al. 2020

Journal of Viral Hepatitis

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Hepatitis C virus (HCV) and HIV are major causes of worldwide disease. We aimed to evaluate the effect of a combined screening programme, which included a risk-assessment questionnaire and rapid tests for point-of-care diagnosis, on screening and new diagnosis rates. This prospective, cluster randomized study was carried out in primary care. The intervention arm included a 4-hour educational programme, the use of a risk-assessment questionnaire and rapid tests. In the control centres, only the educational intervention was provided. The main variables compared were the screening

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Section: Discussionmentioning

confidence: 99%

Hepatitis C and HIV combined screening in primary care: A cluster randomized trial

Martínez-Sanz

Vivancos

Sánchez-Conde

et al. 2020

Journal of Viral Hepatitis

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“…En el documento de diagnóstico en un solo paso (DUSP) de la hepatitis C elaborado conjuntamente por la AEEH y otras sociedades se pueden observar cuáles son los marcadores del virus de la hepatitis C, así como la definición de infección activa (58). El DUSP consiste en la investigación de viremia en todos los pacientes de nuevo diagnóstico serológico.…”

Section: Simplificación Del Diagnóstico Del Vhcunclassified

Eliminación de la hepatitis C. Documento de posicionamiento de la Asociación Española para el Estudio del Hígado (AEEH)

Crespo

Albillos

Buti³

et al. 2019

Gastroenterología y Hepatología

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“…3,8,9 To reduce diagnostic barriers, a one-step diagnosis was introduced in the National Health System (NHS) in 2018, by which viremia testing is conducted in the same blood sample in all patients who have a newly positive HCV antibody (anti-HCV+) test. 10 However, patients with anti-HCV+ before this strategy was implemented could remain undiagnosed if they were not referred to the gastroenterology specialists or if they failed to complete the diagnostic process. 11 We aimed to identify and retrieve potentially HCV-infected patients lost in the HCV care cascade in a Spanish NHS hospital and offer them HCV treatment.…”

Section: Introductionmentioning

confidence: 99%

HCV microelimination strategies: An interventional study in diagnosed patients without access to the system

Veloz

Bellido

Ruíz

et al. 2021

Liver International

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Hepatitis C virus (HCV) one-step diagnosis improves recovery in patients with active infection. However, patients with previous anti-HCV+ may be excluded. We aimed to identify and retrieve non-referred or lost-to-follow-up HCV-infected patients. All anti-HCV+ patients seen in our hospital between 2013 and 2018 were included.In the first phase, we identified anti-HCV+ patients who were not referred to the Gastroenterology Unit (GU) or lost-to-follow-up. In the second phase, recovered patients were invited for a one-step visit for liver evaluation. A total of 1330 anti-HCV+ patients were included: 21.7% had not been referred to GU, and 23.1% were lostto-follow-up. In the second phase, 49.6% of patients were contacted, and 92.8% attended a medical consultation: 62.7% had active infection, 92.2% were treated, and 86.5% achieved SVR (ITT). We concluded that screening microbiological data and referring unidentified patients with active HCV infection directly to specialists is an effective tool in achieving HCV microelimination.

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The efficiency of several one-step testing strategies for the diagnosis of hepatitis C

Cited by 4 publications

References 24 publications

Hepatitis C and HIV combined screening in primary care: A cluster randomized trial

Hepatitis C and HIV combined screening in primary care: A cluster randomized trial

Eliminación de la hepatitis C. Documento de posicionamiento de la Asociación Española para el Estudio del Hígado (AEEH)

HCV microelimination strategies: An interventional study in diagnosed patients without access to the system

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