The efficiency of O-(beta-hydroxyethyl)-rutosides in reducing the incidence of superficial venous insufficiency in patients with calf muscle pump dysfunction

Abstract

Objective We aimed to evaluate the efficiency of O-(beta-Hydroxyethyl)-rutosides (Oxerutin) in reducing the incidence of venous system disease among patients with calf muscle pump dysfunction secondary to immobilization due to lower-limb fractures. Methods A total of 60 patients with lower-limb fractures and immobilized in plaster casts were included in this study randomized into control (n = 30; mean: 30.37 ± 6.03 years; 73.3% males; no treatment) and experiment (n = 30; mean: 31.67 ± 4.76 years; 66.6% males; Oxerutin, 500 mg po q12hr) treatment groups. Doppler ultrasound was performed to evaluate the effect of oxerutin on the alterations in the venous circulation. Results Patients in the control group were determined to be more commonly affected from the below-knee immobilization in terms of venous dysfunction in the great saphenous vein in the below-knee region when compared with the patients in the oxerutin treatment group (46.7 vs. 13.3%, respectively; p = 0.011). Incidence of reflux in the small saphenous vein was more common in the control group during the healing period when compared with the experiment group (40.0 vs. 10.0%, respectively; p = 0.017). None of the patients developed venous thrombosis. Conclusions In conclusion, the impairment of the lower extremity muscle pump should be considered as an important risk factor for venous disease, and should be evaluated. O-(beta-Hydroxyethyl)-rutosides during 6-8 week cast immobilization for a lower limb fracture may be an effective prophylactic regimen in reducing the incidence of reflux in the below-knee superficial veins.

Targeting Cardiovascular Diseases by Flavonols: An Update

“…Flavonols’ effects on the incidence of venous-system disease, advanced glycation end products (AGEs), and biomarkers of heart health risk have also been reported in recent clinical studies [ 89 , 93 , 94 , 95 ]. Blood biomarkers of heart health, such as homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL), gamma-glutamyl transferase (GGT), uric acid, and blood lipid profile were investigated among the Russian population under a multivitamin, multimineral, and phytonutrient (VMP) supplement which contained quercetin.…”

“…O-(b-Hydroxyethyl)-rutosides (Oxerutin) are a standardized combination of the semisynthetic flavonoids created by replacing the hydroxyl groups with hydroxyethyl groups in the naturally occurring flavonol rutin. Yildiz et al showed that 6–8-week Oxerutin intake reduced the incidence of superficial venous reflux in the distal crural veins in cast immobilization for lower-limb-fracture patients [ 95 ].…”