The efficiency of extended postoperative antibiotic prophylaxis in orthognathic surgery: A prospective, randomized, double-blind, placebo-controlled clinical trial

Ghantous, Yasmine; Araidy, Sharif; Yaffe, Victoria; Mirochnik, Roman; El-raziq, Murad Abdol; El-Naaj, Imad Abu

doi:10.1016/j.jcms.2018.11.017

Cited by 20 publications

(13 citation statements)

References 16 publications

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“…In contrast, Ghantous et al 21 compared a prolonged 5-day regimen to single-dose antibiotic prophylaxis, which yielded no statistically significant differences between the two groups. As a result, their study group cautiously proposed a reduction in antibiotic administration in healthy patients.…”

Section: Discussionmentioning

confidence: 97%

Surgical site infections in orthognathic surgery: prolonged versus single-dose antibiotic prophylaxis

Remschmidt

Schwaiger

Gaessler

et al. 2023

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 97%

Surgical site infections in orthognathic surgery: prolonged versus single-dose antibiotic prophylaxis

Remschmidt

Schwaiger

Gaessler

et al. 2023

International Journal of Oral and Maxillofacial Surgery

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“…Several authors showed that infection rates were lower with systematic extended postoperative antibiotics 4 , 16 , 22 , 25 – 27 . Nevertheless, these findings were recently challenged by Ghantous et alin a prospective randomized double blind placebo controlled clinical trial 28 . Lindeboom et alreported similar findings in a prospective randomized trial evaluating the SSI rates with CLINDAMYCIN (Table 2 ) 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

Cousin

Boulétreau

Giai

et al. 2020

Sci Rep

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Surgical site infections (SSI) occur in 1.4% to 33.4% of cases after orthognathic surgery. This type of complication is a major concern to surgical teams, but there is no consensus for the prevention and treatment of SSI in orthognathic surgery. The purpose of this descriptive study was to evaluate the severity and the consequences of postoperative infections. The charts of all the patients operated on by the orthognathic surgery team between January 2015 and July 2017 were collected. All types of orthognathic procedures (Le Fort I maxillary osteotomy, bilateral sagittal split mandibular osteotomy, and genioplasty) were screened, and patients diagnosed with SSI were included. Demographic data, timing and severity of the infection, as well as long-term complications were recorded. Five hundred and twelve patients were screened. Forty-one patients (8%) presenting with SSI were included. There were 18 men and 23 women. The site of the infection was mandibular for 38 patients (92.7%) and maxillary for 3 patients (7.3%). The average time between surgery and infection was 31.5 days. Twenty-four patients received isolated oral antibiotics for inflammatory cellulitic reaction (58.8%), 15 patients had a localized collection treated by incision and drainage under local anesthesia (36.6%), and 2 patients had an extensive collection requiring surgical drainage under general anesthesia (4.9%). Five patients (12.2%) needed hardware removal for plate loosening, and 2 patients (4.9%) developed chronic osteomyelitis. Infection following orthognathic surgery is easily treated most of the time with no long-term complications. In cases of patients with potential risk factors for severe infection, antibiotics may be given with curative intents.

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“…Their acceptance is worldwide, and there has been a marked increase in their application for correcting congenital and acquired dentofacial discrepancies [13]. The use of antibiotic prophylaxis reduces the incidence of infections in these procedures [7], but the duration of postoperative antibiotic protocols differs, and the issue remains controversial [3,5,14,15]. SSI continues to be the second most common cause of healthcare-associated infections in Europe and the USA [16].Due to the anxiety associated with postoperative SSI, many surgeons tend to prescribe antibiotics without considering their adverse side effects.…”

Section: Discussionmentioning

confidence: 99%

Winds of Change in Antibiotic Therapy following Orthognathic Surgery

et al. 2022

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Background and objectives: This retrospective cohort study aimed to compare three postoperative antibiotic protocols of different durations on surgical-site-infection (SSI) rates following orthognathic surgery for the correction of jaw deformities. Materials and methods: An analysis on data collected from the medical files of 209 patients who underwent orthognathic surgery between 2010 and 2019 was conducted. The patients were divided into three groups according to the postoperative antibiotic protocol—Group 1 (24 h), Group 2 (2–3 days), and Group 3 (>3 days). Dependent and independent variables were collected, analyzed, and compared between the three groups. Results: Group 1 included 30 patients (14.3%), Group 2 included 123 patients (58.9%), and Group 3 included 56 patients (26.8%). The vast majority of the postoperative antibiotics were amoxicillinand clavulanic acid (87.1%). The duration of the surgery and the use of a feeding tube were significantly different between Groups 1 and 3 (p < 0.001 and p = 0.005, respectively). There was no significant difference in SSI rates between the three groups (p = 0.642). The use of antibiotics beyond the immediate postoperative period provides no increased benefit regarding infection prevention. Conclusions: In young and healthy patients undergoing orthognathic surgery, a 24hregimen of postoperative antibiotics may be sufficient.

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The efficiency of extended postoperative antibiotic prophylaxis in orthognathic surgery: A prospective, randomized, double-blind, placebo-controlled clinical trial

Cited by 20 publications

References 16 publications

Surgical site infections in orthognathic surgery: prolonged versus single-dose antibiotic prophylaxis

Surgical site infections in orthognathic surgery: prolonged versus single-dose antibiotic prophylaxis

Severity and long-term complications of surgical site infections after orthognathic surgery: a retrospective study

Winds of Change in Antibiotic Therapy following Orthognathic Surgery

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