Winds of Change in Antibiotic Therapy following Orthognathic Surgery

Peleg, Oren; Mahmoud, Reema; Ianculovici, Clariel; Arbel, Shimrit; Kleinman, Shlomi; Shuster, Amir

doi:10.3390/medicina58020263

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large Japanese study of 181 patients has shown that a shorter duration of postoperative antibiotic therapy (≤3 days) was an independent risk factor for SSI ( 30 ). Contrastingly, Peleg et al ( 31 ) compared 209 orthognathic surgery patients by dividing them into three groups based on the duration of postoperative antibiotic therapy (24 hours, 2-3 days, and >3 days), only to note no difference in the risk of SSI in the three groups. Gaal et al ( 32 ) in a retrospective review of 333 patients assessed if additional postoperative antibiotics to intraoperative antibiotics reduced SSI after orthognathic surgery.…”

Section: Discussionmentioning

confidence: 99%

Impact of long-term vs. short-term and single day vs. single dose of antibiotic prophylaxis in reducing infection rates after orthognathic surgery: a systematic review and meta-analysis

Tang,

Wen,

Yang

2024

Med Oral

View full text Add to dashboard Cite

Background This review was designed to examine the effect of long-term (≥2 days) vs. short-term (1 day) and single-day vs. single preoperative doses of antibiotic prophylaxis on surgical site infection (SSI) rates after orthognathic surgery. Material and Methods PubMed, Web of Science, Embase, and Scopus were searched for randomized controlled trials (RCTs) without any date or language restriction till 1st September 2023. SSI rates were pooled to generate risk ratio (RR). Results Eight RCTs comparing long-term vs. short-term and three RCTs comparing single day vs. single preoperative dose of antibiotic prophylaxis were included. Meta-analysis showed that the use of long-term antibiotic prophylaxis significantly reduced the risk of SSI after orthognathic surgery as compared to short-term antibiotics [RR:0.42 (95% CI: 0.23, 0.76) I2=0%]. Meta-analysis also noted that patients receiving a single day of antibiotic prophylaxis had significantly reduced risk of SSI as compared to those receiving only a preoperative single dose of antibiotics [RR:0.28 (95%: 0.09, 0.82) I2=0%]. Conclusions Evidence from a limited number of RCTs with moderate to high risk of bias shows that two to seven days of long-term antibiotic prophylaxis reduces the risk of SSI as compared to single-day antibiotic therapy. Also, a single day of antibiotics may be more beneficial than a single pre-operative dose of antibiotic. Key words: Penicillin, antimicrobials, infection, sagittal split osteotomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of long-term vs. short-term and single day vs. single dose of antibiotic prophylaxis in reducing infection rates after orthognathic surgery: a systematic review and meta-analysis

Tang,

Wen,

Yang

2024

Med Oral

View full text Add to dashboard Cite

show abstract

“…Accordingly, the literature usually contains either prospective, randomised studies with quite small numbers [6, 7, 27-29] or retrospective studies with larger numbers of cases [3,9,20,21,23,24,30]. Both approaches clearly minimise the signi cance.…”

Section: Discussionmentioning

confidence: 99%

Surgical Site Infections and Antibiotic Prophylaxis in Orthognathic Surgery

Naros

Awad

et al. 2023

Preprint

View full text Add to dashboard Cite

Background This study was conducted to determine surgical site infection (SSI) rates and potential risk factors as well as to evaluate antibiotic prophylaxis in orthognathic surgery. Methods This retrospective observational study included patients who received orthognathic surgery. SSIs and their management were assessed for up to one year post-operatively. Various predictor variables were assessed. Results In total 291 patient met the inclusion criteria (56.7% female). The mean age at surgery was 25.5 ± 8.5 years. Fifty-four patients (18.6%) were diagnosed with a craniofacial malformation. Relevant previous surgeries were documented in about one quarter of included patients (n = 75). Ninety-two percent of patients (n = 267) received intraoperative single-dose antibiotic prophylaxis. Surgical site infections occurred in 12.4% (n = 36) of patients. There was a significant association between postoperative infections and type of surgery (P = .037) as well as type of drainage (P = .002). Statistical analyses also revealed a higher prevalence of smokers (P = .036) and previous surgically assisted rapid palatal expansion (SARPE) (P = .018) in the infection group. Furthermore, no significant relationships were observed between postoperative infections and various co-factors (i.e. antibiotic regime, age at surgery, gender, associated craniofacial malformations, surgery duration, displacement distances, mandibular setback vs. advancement). Conclusion Low rates of SSIs occurred following an intraoperative single-dose antibiotic regime. None of the SSIs had a significant effect on the final surgical outcome. Present data do not warrant escalation of the antibiotic regimen. Postoperative smoking and capillary drainage should be avoided.

show abstract

Antibiotic prophylaxis and surgical site infections in orthognathic surgery – a retrospective analysis

Naros,

Awad

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

Background This study was conducted to determine surgical site infection (SSI) rates and potential risk factors as well as to evaluate antibiotic prophylaxis in orthognathic surgery. Methods This retrospective observational study included patients who received orthognathic surgery. SSIs and their management were assessed for up to one year post-operatively. The applied antibiotic regime and other possible influencing factors (smoking, age, site of infection, drainage, duration of surgery, displacement distances, craniofacial malformations) were assessed. Results In total 291 patient met the inclusion criteria (56.7% female). The mean age at surgery was 25.5 ± 8.5 years. Fifty-four patients (18.6%) were diagnosed with a craniofacial malformation. Relevant previous surgeries were documented in about one quarter of included patients (n = 75). Ninety-two percent of patients (n = 267) received intraoperative single-dose antibiotic prophylaxis. Surgical site infections occurred in 12.4% (n = 36) of patients. There was a significant association between postoperative infections and type of surgery (P = .037) as well as type of drainage (P = .002). Statistical analyses also revealed a higher prevalence of smokers (P = .036) and previous surgically assisted rapid palatal expansion (SARPE) (P = .018) in the infection group. Furthermore, no significant relationships were observed between postoperative infections and various co-factors (i.e. antibiotic regime, age at surgery, gender, associated craniofacial malformations, surgery duration, displacement distances, mandibular setback vs. advancement). Conclusion Low rates of SSIs occurred following an intraoperative single-dose antibiotic regime. None of the SSIs had a significant effect on the final surgical outcome. Present data do not warrant escalation of the antibiotic regimen. Postoperative smoking and capillary drainage should be avoided.

show abstract

Winds of Change in Antibiotic Therapy following Orthognathic Surgery

Cited by 3 publications

References 21 publications

Impact of long-term vs. short-term and single day vs. single dose of antibiotic prophylaxis in reducing infection rates after orthognathic surgery: a systematic review and meta-analysis

Impact of long-term vs. short-term and single day vs. single dose of antibiotic prophylaxis in reducing infection rates after orthognathic surgery: a systematic review and meta-analysis

Surgical Site Infections and Antibiotic Prophylaxis in Orthognathic Surgery

Antibiotic prophylaxis and surgical site infections in orthognathic surgery – a retrospective analysis

Contact Info

Product

Resources

About