The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: a double blind, randomized clinical trial

Rasheedy, Radwa; Sammour, Hazem; Elkholy, Abdellatif; Salim, Yasmine

doi:10.1007/s12020-020-02315-3

Cited by 14 publications

(17 citation statements)

References 30 publications

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“…In accordance with this study [11] have discovered that 92.5% of ladies got VD had effective ovulation after the enlistment cycles contrasted and 78.5% in the fake treatment gathering (p = 0.007). The mean distance across of the prevailing follicle was 18.07 ± 1.37 mm in the treatment gathering and was 16.79 ± 3.00 mm in placepo bunch with p <0.001.…”

Section: Discussionsupporting

confidence: 87%

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Effect of Vitamin D Supplementation in Improving Pregnancy Rates in Infertile Women with PCOS

Nosseir

Sadek

Awad

et al. 2021

Benha Journal of Applied Sciences

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Polycystic ovarian condition (PCOS) is the most well-known endocrine problem that influences ladies in the youngster bearing period. The point of the current examination was to contemplate the impact of nutrient D supplementation in nutrient D inadequate PCOS ladies, as respects the clinical pregnancy and ovulation rates. Patient and techniques : This is a Randomized controlled clinical preliminary investigation included 100 nutrient D inadequate/lacking fruitless ladies with an analysis of PCOS. Serum 25-OH-VD levels were estimated and ladies were haphazardly partitioned into Vitamin D and placepo gatherings. Following 3 months of metformin ± nutrient D supplementation, all included ladies got ovulation enlistment by letrozole 2.5 mg. Sequential trans vaginal ultrasound was performed and evaluated. Results: Following nutrient D3 supplementation, the rate of continuous pregnancy demonstrated genuinely huge expansion in nutrient D gathering contrasted with fake treatment group(39.1% and 18.4%% separately) P = 0.025. Likewise measurably critical expansion in ovulation after the enlistment cycles in vit D gathering contrasted with the fake treatment gathering (p = 0.001, 0.001 and 0.045) through three continuous acceptance cycles . End: In subfertile ladies with PCOS, Vitamin D supplementation may have a possible adjuvant part to standard enlistment of ovulation regimens.

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Section: Discussionsupporting

confidence: 87%

“…In accordance with our stydy [11] in their investigation at Ain Shams University during the time frame between January 2018 and September 2018. discovered that clinical and bio substance pregnancy rates expanded in nutrient D gathering over the placepo gathering yet was not measurably huge (p = 0.141 and 0.105 separately) .…”

Section: Discussionsupporting

confidence: 82%

Effect of Vitamin D Supplementation in Improving Pregnancy Rates in Infertile Women with PCOS

Nosseir

Sadek

Awad

et al. 2021

Benha Journal of Applied Sciences

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“…This similar to Brown et al 26 who reported in their study that clomiphene citratre has no difference on getting pregnancy which was in agreement with our results. Also, Rasheed et al 27 revealed in their study that addition of vitamin D to clomifine citrate significantly improve the ovulation rate which run in lines with our results but in our results the difference was not significant.…”

Section: Number Of Cysts 2 MMsupporting

confidence: 91%

Effect Of Adding Vitamin D Supplement to Clomiphene Citrate For Induction Of Ovulation In Cases Of Overweight PCOS Women

Ghanem¹,

Al-Garhai

El-Omda

2022

Al-Azhar International Medical Journal

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Background: Polycystic ovary syndrome had unclear etiology, affecting 6-12% of females due to undetermined optimal treatment. Studies indulge vitamin D in pathogenesis of PCOS but without evidence demonstrating its effect on PCOS. Aim of the work: Our objective is evaluation of vitamin D supplementation on ovulation in sub-fertile females with PCOS. Patients and methods: Two hundred cases of PCOS at Al-Azhar University Hospital and Damanhour teaching Hospital were selected based on clinical diagnosis, ultrasonographic and laboratory findings. They were 100 cases of PCOS managed by clomifine citrate plus vitamin D and another 100 cases managed only by clomifine citrate. Results: Our results didn't show a difference between both groups regarding demographic data, hormonal profile, fasting sugar level of both cases and controls and also, radiological findings between both groups. There was estradiol rise in serum level at time ovulation of cases; and increase pregnancy rate after induction but in doesn't reach a significant level without difference between both groups regarding complications after therapy. Conclusion:We can concluded that addition of vitamin D to clomifine is beneficial in increasing pregnancy rate even with a non-significant effect and so, we recommend its addition to the protocol of management in cases of PCOS.

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“…Progesterone, also known as progesterone, is one of the progesterone secreted by the human ovaries. Progesterone can regulate the patient's hormone levels, protect the endometrium, promote the maturation and shedding of the endometrium, and restore the patient's menstrual cycle to normal [24][25][26][27]. Vitamin B is the catalyst of dopamine conversion, which can increase dopamine secretion in the patient's body.…”

Section: Discussionmentioning

confidence: 99%

Clinical Study of Progesterone Combined with Vitamin B6 in the Treatment of Amenorrhea Endocrine Disorders Caused by Antipsychotics

Zhao

Zhai

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Endocrine disorders such as amenorrhea, lactation, and irregular menstruation caused by antipsychotics are common in female patients. How to reduce or eliminate these adverse reactions is a matter of concern. Objective. To evaluate the therapeutic effect of progesterone in combination with vitamin B6 in the treatment of antipsychotic-induced amenorrhea. Methods. In our hospital, from May 2019 to May 2021, 120 patients with amenorrhea caused by antipsychotics who underwent surgery were selected for this prospective study. The random residue grouping method divided them into a progesterone group (60 cases) and a vitamin B6 group (60 cases). Among them, the progesterone group was treated only with progesterone, while the vitamin B6 group was given progesterone in combination with vitamin B6. The differences in endocrine index, prolactin, uterine size, and endometrial thickness, effectiveness, and safety analysis of the progesterone and vitamin B6 groups of patients were observed and compared. Results. Before treatment, there was no change in the comparison of endocrine indexes between the progesterone and vitamin B6 groups ( P > 0.05 ). After 1 month of treatment, there were significant differences in estradiol, prolactin, and follicle-stimulating hormone between the progesterone and vitamin B6 groups of patients ( P < 0.05 ). After 1 month of treatment, there were significant differences in prolactin, uterine size, and endometrial thickness, and the vitamin B6 group was significantly lower than the progesterone group ( P < 0.05 ). The clinical efficiency of 95.00% in the vitamin B6 group was significantly higher than 83.33% in the progesterone group ( P < 0.05 ). There were no adverse reactions in the progesterone and vitamin B6 groups. Conclusion. The effectiveness of progesterone combined with vitamin B6 in treating amenorrhea caused by antipsychotics is significantly better than simple progesterone, which can effectively improve the endocrine condition of patients and provide a reference for the clinical treatment of amenorrhea caused by antipsychotics.

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The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: a double blind, randomized clinical trial

Cited by 14 publications

References 30 publications

Effect of Vitamin D Supplementation in Improving Pregnancy Rates in Infertile Women with PCOS

Effect of Vitamin D Supplementation in Improving Pregnancy Rates in Infertile Women with PCOS

Effect Of Adding Vitamin D Supplement to Clomiphene Citrate For Induction Of Ovulation In Cases Of Overweight PCOS Women

Clinical Study of Progesterone Combined with Vitamin B6 in the Treatment of Amenorrhea Endocrine Disorders Caused by Antipsychotics

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