The efficacy of single-dose albendazole for the treatment of ascariasis

Putra, Deddy Satriya; Dalimunthe, Wisman; Lubis, Munar; Pasaribu, Syahril; Lubis, Chairuddin P.

doi:10.14238/pi45.3.2005.118-22

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…It is used as a baseline data for the cure rate and ERR estimation, also to grade the infection as light, moderate, and heavy, according to WHO guidelines for STHs. Infection intensity classifications were as follows: light A. lumbricoides 1-4999 eggs/gram stool (EPG), moderate 5000-49999 EPG and heavy ≥ 50000 EPG [22]; A. duodenale, light 1-1999 EPG, moderate 2000-3999 EPG, and heavy ≥4000 EPG [23] .…”

Section: Samples Collection and Parasitological Proceduresmentioning

confidence: 99%

Molecular monitoring of the therapeutic effect of Albendazole on Ascaris lumbricoides and Ancylostoma duodenale infected children using conventional multiplex PCR

Yahia

Moawad

Farag

et al. 2019

Parasitologists United Journal

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Soil-transmitted helminths (geohelminths) belong to the group of neglected tropical diseases. This assembly of infectious diseases include parasites namely A. lumbricoides, T. trichiura, and the two hookworm species, A. duodenale and N. americanus causing an extensive variety of clinical symptoms and signs. S. stercoralis is one of the most important and often neglected additional STH affecting 10-40% of the population mainly in sub-Saharan Africa and Southeast Asia [1]. Geohelminths can affect human health either directly by damaging the internal mucosa of the gut and feeding on host's blood and serum, or indirectly through production of inflammatory cytokines that affect appetite and food intake of hosts especially children [2]. Both mechanisms are a dual burden of parasitic infection leading to malabsorption with drastic deficiencies in macro and micronutrients which in turn leads to a malnutrition state that increases susceptibility to infection by inducing alterations in host immune function. These factors not only affect the physical development of children, but also they impair their cognitive development leading to retarded academic performance [3]. Geohelminths are transmitted by a fecal-oral route, which explains its high rate of prevalence in areas deprived of proper socioeconomic development and/or lack of proper sanitary environmental health conditions; criteria known to be present in low and middle income countries, including Egypt [4]. In developing countries, these worms continue to represent an actual health problem infecting millions of people and exhausting its health budget annually. Globally, the infection with at least one species of geohelminths occurred in more than a billion patients. Most of them are those living in low income countries deprived of education, health

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Section: Samples Collection and Parasitological Proceduresmentioning

confidence: 99%