The efficacy of silicone gel for the treatment of hypertrophic scars and keloids

Puri, Neerja; Talwar, Ashutosh

doi:10.4103/0974-2077.58527

Cited by 82 publications

(65 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…29 Whereas another study draws attention to certain SGS products leading to possible skin irritation in hot climates. 50 A limitation of SGS's practical application is with burn cases, in which the affected area may be very large. In these situations SGS can prove impractical.…”

Section: Limitations Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

View full text Add to dashboard Cite

Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring. SCOPE AND SIGNIFICANCESilicone gel sheeting (SGS) has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed. As such, topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. This article aims to review a breadth of literature to gain an insight not only into how, but also why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance as a comparison. TRANSLATIONAL RELEVANCESilicone has been used for more than 30 years in the treatment of cutaneous scars.1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.

show abstract

Section: Limitations Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

View full text Add to dashboard Cite

show abstract

“…A pesar de que la paciente reportada no presentó ningún otro tipo de alergia, la literatura menciona que un dato clínico de gran utilidad en relación a los pacientes con algún tipo de reacción de hipersensibilidad hacia la henna negra, es que suelen presentar reacciones cruzadas contra diferentes sustancias, esto por la similitud molecular de la PPD con colorantes utilizados en la industria textil (naranja disperso 3, amarillo disperso 3, rojo 1, colorantes del caucho negro), cosmética (3-aminofenol, 4-aminofenol, paratoluendiamina y diaminotoluensulfato), medicamentos para la diabetes (sulfonamidas), anestésicos locales (benzocaína y procaína), derivados del ácido paraaminobenzoico (PABA) y diuréticos como la hidroclorotiazida 10,11 . En la actualidad se han utilizado diversos tratamientos para pacientes con hipersensibilidad hacia la henna negra, donde los más utilizados son corticoides de moderada potencia, siendo estos por sí solos, en ocasiones, incapaces de evitar secuelas estéticas como la hipopigmentación y cicatrices hipertróficas en la zona de la lesión [5][6][7]9 .…”

Section: Discussionunclassified

“…Esto lo podemos adjudicar a las característi-cas farmacocinéticas y farmacodinámicas del gel de silicona, entre las que destacan: el aumento en la hidratación del estrato corneo, facilitación en la regulación de los fibroblastos y disminución en la producción de colágena, regulación de factores de crecimiento (TGFβ y FGFβ), reducción de prurito y molestias en la zona. Podemos considerar que el uso de gel de silicona puede ser útil para evitar la aparición de la cicatrices hipertróficas, razón por la que, probablemente, la paciente no presentó cicatriz hipertrófica residual 11 . También consideramos que las características farmacodinámicas y el potencial antiinflamatorio de los esteroides tópicos como el furoato de mometasona, un esteroide tópico de baja absorción y potencia media, probablemente contribuyeron al buen pronóstico de la paciente, pese a lo que en la literatura se ha utilizado poco para el tratamiento de esta patología 12 .…”

Section: Discussionunclassified

Reacción a un tatuaje de henna negra tratado con furoato de mometasona y gel de silicona: Caso clínico

Aboitiz-Rivera

Blachman‐Braun

Ferrer-Arellano

2014

Rev. chil. pediatr.

View full text Add to dashboard Cite

Reaction to a black henna tattoo treated with mometasone furoate and silicone gel: case report Black henna tattoos have paraphenylenediamine (PPD), which contains a product of herbal origin, which due to its molecular characteristics is capable of inducing, in susceptible individuals, a type IV hypersensitivity reaction. It clinically manifests as a contact dermatitis that usually when it disappears, scarring and hypopigmentation are left in the injured area. objective: To describe the case of a patient with hypersensitivity to henna tattoo and to present the most relevant phenomena associated with this condition. Case report: The case of a 6 year-old patient with a black henna tattoo on his right leg, who was diagnosed with contact dermatitis probably attributed to PPD, is presented. Mometasone furoate and topical silicone gel treatment was started with good response. Conclusion: Mometasone furoate and silicone gel are a good possible therapeutic option for treating contact dermatitis caused by PPD as the dermatosis was resolved without residual lesions. (Key words: Henna, paraphenylenediamine, type IV hypersensitivity reaction, mometasone furoate, silicone gel). Rev Chil Pediatr 2014; 85 (6): 720-723 resumen Los tatuajes de henna negra son aquellos que contienen parafenilendiamina (PPD), que contienen un producto de origen herbal, que por sus características moleculares es capaz de inducir, en individuos susceptibles, una reacción de hipersensibilidad tipo IV. Se manifiesta clínicamente como una dermatitis de contacto, que generalmente al desaparecer, persiste de manera residual una cicatriz hipertrófica e hipopigmentación en la zona lesionada. objetivo: Describir el caso de un paciente con hipersensibilidad al tatuaje de henna, y presentar los fenómenos más relevantes asociados a esta patología. Caso clínico: Paciente de 6 años de edad, que se realizó un tatuaje con henna negra en la pierna derecha, en quien se diagnosticó posteriormente una dermatitis de contacto atribuida probablemente a la PPD. Se comenzó tratamiento con furoato de mometasona y gel de silicona con buena respuesta por vía tópica. Conclusión: El furoato de mometasona y gel de silicona son una CASO CLíNICO Rev Chil Pediatr 2014; 85 (6): 720-723

show abstract

“…Occlusion appears and the skin becomes more hydrated. Keratinocytes are stimulated to create and secrete necessary cytokines and growth factors [1][2][3][4][5][6][7][8][9][10][11][22][23][24][25][26].…”

Section: Common Therapeutic Methodsmentioning

confidence: 99%

Keloids: current prophylactic and therapeutic methods

Bienias¹,

Kaszuba²

2012

pdia

View full text Add to dashboard Cite

A b s t r a c tProphylaxis and therapy of keloids present a big challenge for medicine, despite the increasing knowledge about their pathogenesis. There are a lot of therapeutic methods but their effectiveness is still limited and unsatisfactory. These methods are divided into surgical, pharmacological and physical ones as well as the most frequently applied combined therapy, which is the most effective one. A surgical way of removing keloids is becoming less common and the method of intralesional application of steroids still remains the treatment of choice. In addition to the above there are cryotherapy, laser therapy, pressure therapy, X-ray irradiation and silicone products in a form of gels and dressings. Relatively new methods are intralesional injections of verapamil and 5-fluorouracil. Enalapril and troglitazone, which are currently used in the treatment of hypertension and diabetes, are expected to be of use as well. Biological drugs like monoclonal antibodies against tumor growth factor (TGF)-β1, TGF-β2 and vascular endothelial growth factor and analogues of TGF-β3 are also potential solutions in the treatment of keloids. Further studies on the treatment of keloids should result in more efficient therapies. K Ke ey y w wo or rd ds s: :

show abstract

The efficacy of silicone gel for the treatment of hypertrophic scars and keloids

Cited by 82 publications

References 15 publications

The Use of Silicone Adhesives for Scar Reduction

The Use of Silicone Adhesives for Scar Reduction

Reacción a un tatuaje de henna negra tratado con furoato de mometasona y gel de silicona: Caso clínico

Keloids: current prophylactic and therapeutic methods

Contact Info

Product

Resources

About