The efficacy of povidone-iodine, hydrogen peroxide and a chemical multipurpose contact lens care system against Pseudomonas aeruginosa on various lens case surfaces

Yamasaki, Katsuhide; Mizuno, Yohei; Kitamura, Yoshiyuki; McCanna, David J.; Ngo, William; Jones, Lyndon

doi:10.1016/j.clae.2020.02.012

Cited by 8 publications

(16 citation statements)

References 35 publications

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“…Also, as Acanthamoeba are eukaryotic organisms, as are humans, there is the probability that killing these would have toxic effects on human cells, so getting the right balance between killing the amoebae and toxicity to human cells may be difficult. The five most commonly used disinfectants in contact lens care solutions are hydrogen peroxide, PHMB (polyhexanide; polyaminopropyl biguanide; also known as Dymed®), polyquaternium-1 (PQ1, also known as POLYQUAD®), myristamidopropyl dimethylamine (MAPD, also known as ALDOX®) and alexidine, although another MPDS uses polylysine as the main disinfectant [260,[292][293][294][295][296][297] (Table 4). Some care solutions combine some of the above agents or incorporate additional agents (i.e., amidoamine and chlorite) to boost antimicrobial efficacy.…”

Section: Disinfectantsmentioning

confidence: 99%

“…Some care solutions combine some of the above agents or incorporate additional agents (i.e., amidoamine and chlorite) to boost antimicrobial efficacy. More recently, a solution containing povidone-iodine has been introduced into the marketplace, especially in Japan [296,297]. The latter system comprises a contact lenses storage case, diluent and a tablet containing povidone-iodine at 500 ppm, giving 50 ppm active iodine [296].…”

Section: Disinfectantsmentioning

confidence: 99%

“…Iodine penetrates microbial cell walls, oxidises their constituents disrupting their C-H, N-H, and S-H bonds, and integrates within the cells as well to minimise toxicity [298,[304][305][306]. Similar to hydrogen peroxide-systems, povidone-iodine requires neutralization, in this case through the addition of an ascorbic acid tablet to complete neutralization [297]. The liberation of iodine gas during the disinfection process of contact lenses also enables disinfection even of surfaces not in direct contact with the disinfecting solution [297].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…Similar to hydrogen peroxide-systems, povidone-iodine requires neutralization, in this case through the addition of an ascorbic acid tablet to complete neutralization [297]. The liberation of iodine gas during the disinfection process of contact lenses also enables disinfection even of surfaces not in direct contact with the disinfecting solution [297].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

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BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Disinfectantsmentioning

confidence: 99%

Section: Disinfectantsmentioning

confidence: 99%

Section: Mechanism Of Actionmentioning

confidence: 99%

Section: Mechanism Of Actionmentioning

confidence: 99%

See 2 more Smart Citations

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

show abstract

“…Other studies have reported that povidone-iodine is effective against planktonic and adhered bacteria as well as Acanthamoeba, and the results of the current experiments agree with these previous studies. 39,41,42,44 The relationship between drying the lens case and contamination has been previously evaluated. Lens cases whose insides were wet when collected showed significantly higher contamination than dry ones, 27 and air-drying significantly decreased bacterial biofilm compared with recapping using Biotrue.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hygiene Procedures on Lens Case Contamination with Povidone-Iodine or Multipurpose Disinfecting Solutions

Nakagawa¹,

Nakagawa²,

Willcox

et al. 2021

Optom Vis Sci

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SIGNIFICANCE:A multipurpose disinfecting solution (MPDS), which contains povidone-iodine (PI) as a disinfectant, has high disinfecting efficacy not only on planktonic bacterium but also on the case biofilms. The addition of case hygiene practice removed more bacteria from cases than MPDS alone. PURPOSE:This study compared the ability of two MPDSs, one containing PI and another containing polyaminopropyl biguanide and polyquaternium, to reduce bacterial numbers in solution or adhered to the cases following case hygiene procedures.METHODS: Bacterial strains (Delftia acidovorans, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Serratia marcescens, Staphylococcus aureus, and Staphylococcus epidermidis) were exposed to the MPDSs for the recommended disinfection times, and the viable number evaluated according to ISO 14729. Cases were inoculated with bacterial strains and incubated for 24 hours to allow for biofilm formation. Cases were disinfected with both disinfecting solutions for 4 hours and rinsed, followed by recapping or air-drying, or tissue-wiping and air-drying for 18 hours. The number of survivors was counted using standard culture techniques. RESULTS:Both products exceeded the recommended 3-log reduction against planktonic bacteria. Regarding biofilm, after rinsing and recapping wet, the numbers of D. acidovorans (mean difference [95% confidence interval] log 10 colony-forming units per case, −2.9 [0.8 to −4.6], P < .01), P. aeruginosa (−2.0 [0.5 to −3.1], P < .01), S. marcescens (−1.7 [0.8 to −3.5], P < .05), and S. epidermidis (−2.1 [0.6 to −3.5], P < .05) in PI cases were significantly lower than in the dual-disinfectant MPDS storage cases. After air-drying, the PI storage cases had significantly lower numbers of S. maltophilia (−2.6 [0.6 to −4.0], P < .01), D. acidovorans (−1.6 [0.7 to −3.3], P < .05), and S. aureus (−1.6 [0.7 to −3.1], P < .05). The addition of tissue-wiping reduced the bacterial numbers in the MPDS storage cases to levels in the PI storage cases. CONCLUSIONS: Contact lens users should be recommended to tissue-wipe and air-dry their lens storage cases after disinfection with regular MPDS.

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Exploring Potentials and Constraints of H2O2 Water Disinfection for Household Settings

Silva

Sabogal-Paz

2021

Water Air Soil Pollut

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The efficacy of povidone-iodine, hydrogen peroxide and a chemical multipurpose contact lens care system against Pseudomonas aeruginosa on various lens case surfaces

Cited by 8 publications

References 35 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Effect of Hygiene Procedures on Lens Case Contamination with Povidone-Iodine or Multipurpose Disinfecting Solutions

Exploring Potentials and Constraints of H2O2 Water Disinfection for Household Settings

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