The efficacy of neutron radiation therapy in treating salivary gland malignancies

Timoshchuk, Mari-Alina; Dekker, Preston; Hippe, Daniel S.; Parvathaneni, Upendra; Liao, Jay J.; Laramore, George E.; Dillon, Jasjit K.

doi:10.1016/j.oraloncology.2018.11.006

Cited by 23 publications

(13 citation statements)

References 25 publications

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“…A study on 140 cases found that post-treatment trismus occurred in 56%, acute mucositis and xerostomia occurred in approximately 88% and 89% of patients, respectively, and osteoradionecrosis was reported in 5.7% of patients 72 . In the version 2.2019 of the NCCN guidelines for head and neck tumours 7 , there is the following statement: “Results from a retrospective cohort study including 545 patients with salivary gland tumours treated between 1997 and 2010 showed better local control and survival outcomes with neutron therapy, relative to photon therapy 73 . However, risk of late effects with neutron therapy is high and tends to increase over time, with estimates as high as 20% at 9 years.…”

Section: Treatmentmentioning

confidence: 99%

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis

Cantù

2021

Acta Otorhinolaryngol Ital

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SUMMARY The purpose of this review is to analyse the very large number of studies (sometimes contradictory) on adenoid cystic carcinoma (ACC). This second part provides a critical analysis of various treatment described in the literature. Anywhere the primary tumour is located, the most common treatment for ACC is complete surgical resection, with or without post-operative radiotherapy (PORT), while conventional photon and/or electron radiotherapy alone and chemotherapy are commonly used in unresectable or metastatic disease. Fast neutron radiotherapy was used in the past with good local results, but the risk of late effects was high and tended to increase over time. Modern carbon-ion radiotherapy seems to be a valid option in selected cases. The quite universally accepted poor prognostic factors are advanced stage, perineural and intraneural invasion, involved margins, and initial presence or later development of neck metastases. The impact of histologic grade on prognosis is controversial. Owing to the long natural history of ACC, the follow-up for patients must be at least 10 years long.

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Section: Treatmentmentioning

confidence: 99%

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis

Cantù

2021

Acta Otorhinolaryngol Ital

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“…The most recent retrospective cohort study was reported in 2019 by Timoshchuk et al [ 58 ]. A total of 545 patients with salivary gland malignancies treated using FNT between 1997 and 2010 were identified.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

“…The 6- and 10-year local regional control rates were 84% and 79%, respectively. Of the patients, 3% experienced osteoradionecrosis, which the authors noted was comparable to photon treatment [ 58 ]. Previous retrospective series have reported rates of oral complications after FNT for salivary gland cancers, including posttreatment trismus in 56% of patients, acute mucositis in 88% of patients, and acute xerostomia in 89% of patients [ 59 ].…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

Ebner

Malouff

Frank

et al. 2021

International Journal of Particle Therapy

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Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

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“…This is caused by low Linear Energy Transfer (LET) produced by photons [21]. Higher LET such as neutron, and heavy-ion result in more unrepairable double-stranded breaks of DNA within the cell directly; whereas, conventional radiotherapy relies on the formation of free radicals and reactive oxygenated species (ROS) that damage DNA indirectly (table 1) [22].…”

Section: Acknowledgmentmentioning

confidence: 99%

Radiotherapy in Inoperable Mucoepidermoid Parotid Cancer: A Case Report

Octavianus

Kodrat

2021

Indonesian Journal of Cancer

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Introduction: Salivary gland cancer is an uncommon malignancy in the head and neck. The most common histopathologic type in salivary gland malignancies is mucoepidermoid carcinoma (MEC). Radiotherapy has a role in salivary gland malignancy, especially in inoperable cases and postoperative settings. Definitive or postoperative radiotherapy with or without chemotherapy can improve locoregional control (LRC) in patients with parotid mucoepidermoid carcinoma. Case Presentation: We report a case of a 77-year-old male with inoperable MEC of the right parotid, who received definitive radiotherapy. From the three-month evaluation after radiation therapy, we found a significant reduction in the tumor mass. Conclusions: Surgery remains the treatment of choice for patients with salivary gland malignancies. Definitive radiotherapy can be a treatment modality in inoperable cases or patients who refuse surgery. Although the result is not satisfactory, radiotherapy can still give clinical benefits to patients.

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The efficacy of neutron radiation therapy in treating salivary gland malignancies

Cited by 23 publications

References 25 publications

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis

The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

Radiotherapy in Inoperable Mucoepidermoid Parotid Cancer: A Case Report

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