The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck

Abstract

Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. Within the head and neck, adenoid cystic carcinoma and mucosal melanoma are two such histologies, being radioresistant and lying closely proximal to critical structures. Here, we review the use of particle irradiation for adenoid cystic carcinoma and mucosal melanoma of the head and neck.

Pulmonary adenoid cystic carcinoma ‐ a spectrum of disease: two case reports

“…Importantly the reduced risk of secondary malignancies associated with proton therapy is relevant given the young age and long term survival of many of these patients. 19 In conclusion, despite a historic slow growing nature, our case series reflects the anecdotal spectrum experience in real world clinical practice. This tumour demonstrates huge variability not only in histopathology but also the acuity of presentation, symptomatology and prognosis.…”

“…Case number one is consistent with published case series demonstrating good outcomes with this treatment approach. Importantly the reduced risk of secondary malignancies associated with proton therapy is relevant given the young age and long term survival of many of these patients 19 …”

Fulminant Adenoid Cystic Carcinoma of the Maxillary Sinus – A Rare Finding: Case Report

“…The radical resection of the ACK of the maxillary sinus with accompanying neck dissection and adjuvant radiotherapy are the decisive therapy pillars (18). In selected cases, especially in the case of pronounced findings, radiation with protons can also be carried out (19).…”

Recent Advances, Systemic Therapy, and Molecular Targets in Adenoid Cystic Carcinoma of the Head and Neck

“…Even though fast neutron therapy (FNT) seemed to be a promising treatment procedure, it received less consideration in clinical trials due to limited availability, high costs, and challenges with healthy tissue toxicity in treatment cohorts. Side effects such as posttreatment trismus, acute mucositis, and acute xerostomia have been reported [ 60 , 61 ]. Still, the latest case studies including neutron radiation treatment in ACC report a 10-year OS of 62% and osteoradionecrosis rates comparable to that of photon radiation treatment (2–7%) [ 62 ].…”