The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis

Hsiao, An-Fang; Lien, Yi-Chieh; Tzeng, I‐Shiang; Liu, Chien-Ting; Chou, Sheng-Hsun; Horng, Yi-Shiung

doi:10.1016/j.ctim.2021.102775

Cited by 25 publications

(46 citation statements)

References 49 publications

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“…Our analysis found that Zingiberaceae plants, especially ginger, have a positive effect on knee osteoarthritis (Araya‐Quintanilla et al, 2020; Bannuru et al, 2018; Bartels et al, 2015; Dai et al, 2021; Daily et al, 2016; Gong, 2017; Hsiao et al, 2021; Onakpoya et al, 2017; Wang, Singh, et al, 2021; Zeng et al, 2021), migraine (Chen & Cai, 2020), and subjective chronic pain, where the meta‐analysis of subjective chronic pain showed publication bias (Lakhan et al, 2015; Xu et al, 2020). Of these, the qualities of evidence for relief of knee osteoarthritis, migraine and subjective chronic pain were rated as low.…”

Section: Resultsmentioning

confidence: 90%

“…Cur supplementation has been reported to significantly reduce knee osteoarthritis pain (GRADE level: moderate) (Onakpoya et al, 2017) and muscle soreness after exercise (GRADE level: low) (Fang & Nasir, 2020). Nevertheless, study on Cur as an intervention has not shown an effect of attenuating knee osteoarthritis pain (GRADE level: low) (Hsiao et al, 2021). One study on ginger as an intervention failed to show an effect of relieving pain (GRADE level: very low) (Araya‐Quintanilla et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…In terms of antioxidant effects, low-quality meta-analyses indicated that ginger of the Zingiberaceae plants and the functional components Bannuru et al, 2018;Bartels et al, 2015;Dai et al, 2021;Daily et al, 2016;Gong, 2017;Hsiao et al, 2021;Onakpoya et al, 2017;Wang, Singh, et al, 2021;Zeng et al, 2021), migraine (Chen & Cai, 2020), and subjective chronic pain, where the meta-analysis of subjective chronic pain showed publication bias (Lakhan et al, 2015;Xu et al, 2020). Of these, the qualities of evidence for relief of knee F I G U R E 3 Proportions of significant/ not-significant studies between Zingiberaceae plants/Cur and health outcomes osteoarthritis, migraine and subjective chronic pain were rated as low.…”

Section: Antioxidant Effects Of Zingiberaceae Plants/curmentioning

confidence: 99%

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Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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This umbrella review is to recapitulate and grade the available evidence of associations between consumption of Zingiberaceae plants/curcumin (Cur) and multiple health‐related outcomes. This study included 161 meta‐analyses of randomized controlled trials in 76 articles with 67 unique health outcomes. Data on heterogeneity and publication bias are considered to assess the quality of evidence. Based on the different impact of Zingiberaceae plants/Cur on human health, the advantages outweigh the disadvantages. Zingiberaceae plants/Cur can mainly improve metabolic syndrome, non‐alcoholic fatty liver disease, cardiovascular disease, and some chronic inflammatory diseases, likewise, obviously relief the pain of osteoarthritis and related diseases. Ginger supplements have been shown to improve vomiting during pregnancy and to relieve nausea and vomiting caused by chemotherapy and surgery. The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Beneficial associations were found with Cur intervention in gastrointestinal, neurological and oral diseases. Zingiberaceae plants/Cur are generally safe and favorable for multiple health outcomes in humans. High‐quality research is further needed to prove the observed associations.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Section: Antioxidant Effects Of Zingiberaceae Plants/curmentioning

confidence: 99%

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Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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“…As there were no identified placebo-controlled studies using the KOOS in curcumin trials, we estimated the sample size based on studies using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score as an outcome measure. In a meta-analysis comprising 5 studies, an effect size of 0.787 compared to the placebo was identified [ 14 ]. However, as higher doses were often administered, a more conservative effect size of 0.55 was predicted.…”

Section: Methodsmentioning

confidence: 99%

An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study

et al. 2021

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Curcumin, a phytochemical from the spice turmeric, has anti-inflammatory properties and has been shown to have pain-relieving effects. In this 8-week, randomised, double-blind, placebo-controlled study, 101 adults with knee osteoarthritis received either 500 mg twice daily of a standardised curcumin extract (Curcugen®) or placebo. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score (KOOS), knee pain ratings, Japanese Orthopaedic Association Score for Osteoarthritic Knees (JOA), PROMIS–29, and performance-based testing comprising the 40-m fast-paced walk test, 6-min walk test, timed up-and-go test, and 30-s chair stand test. Compared to the placebo, curcumin significantly reduced the KOOS knee pain score (p = 0.009) and numeric knee pain ratings (p = 0.001). Curcumin was also associated with greater improvements (p ≤ 0.05) than the placebo on the timed up-and-go test, 6-min walk test, and the JOA total score; but not the 30-s chair stand test or 40-m fast-paced walk test. Pain-relieving medication was reduced in 37% of participants on curcumin compared to 13% on placebo. The findings support the potential efficacy of curcumin for the treatment of osteoarthritis of the knee but studies of longer duration, varying treatment doses, differing curcumin extracts, and the use of other objective outcome measures will be helpful to expand on these findings.

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“…It possesses a wide array of functional characteristics, including antioxidant and anti-inflammatory [ 15 ] as well as antiviral, antibacterial, and antifungal properties [ 16 ]. Curcumin has been extensively investigated for its cellular and molecular modes of action against cancer [ 17 , 18 ], diabetes [ 19 ], neurological ailments [ 20 ], and osteoarthritis [ 21 ], and even entered several clinical trials [ 22 , 23 ]. Curcumin inhibits cancer cell proliferation [ 24 , 25 ], DNA repair along the p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis [ 26 , 27 ], metastasis by the NF-κB/c-JUN/MMP pathway [ 28 ], and the CXC-chemokine/NF-κB signaling pathway [ 29 , 30 , 31 ] as well as angiogenesis by the protein kinase C/NF-κB/AP-1 pathway [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors

Saeed

Yücer

Dawood

et al. 2022

IJMS

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The improvement of cancer chemotherapy remains a major challenge, and thus new drugs are urgently required to develop new treatment regimes. Curcumin, a polyphenolic antioxidant derived from the rhizome of turmeric (Curcuma longa L.), has undergone extensive preclinical investigations and, thereby, displayed remarkable efficacy in vitro and in vivo against cancer and other disorders. However, pharmacological limitations of curcumin stimulated the synthesis of numerous novel curcumin analogs, which need to be evaluated for their therapeutic potential. In the present study, we calculated the binding affinities of 50 curcumin derivatives to known cancer-related target proteins of curcumin, i.e., epidermal growth factor receptor (EGFR) and nuclear factor κB (NF-κB) by using a molecular docking approach. The binding energies for EGFR were in a range of −12.12 (±0.21) to −7.34 (±0.07) kcal/mol and those for NF-κB ranged from −12.97 (±0.47) to −6.24 (±0.06) kcal/mol, indicating similar binding affinities of the curcumin compounds for both target proteins. The predicted receptor-ligand binding constants for EGFR and curcumin derivatives were in a range of 0.00013 (±0.00006) to 3.45 (±0.10) µM and for NF-κB in a range of 0.0004 (±0.0003) to 10.05 (±4.03) µM, indicating that the receptor-ligand binding was more stable for EGFR than for NF-κB. Twenty out of 50 curcumin compounds showed binding energies to NF-κB smaller than −10 kcal/mol, while curcumin as a lead compound revealed free binding energies of >−10 kcal/mol. Comparable data were obtained for EGFR: 15 out of 50 curcumin compounds were bound to EGFR with free binding energies of <−10 kcal/mol, while the binding affinity of curcumin itself was >−10 kcal/mol. This indicates that the derivatization of curcumin may indeed be a promising strategy to improve targe specificity and to obtain more effective anticancer drug candidates. The in silico results have been exemplarily validated using microscale thermophoresis. The bioactivity has been further investigated by using resazurin cell viability assay, lactate dehydrogenase assay, flow cytometric measurement of reactive oxygen species, and annexin V/propidium iodide assay. In conclusion, molecular docking represents a valuable approach to facilitate and speed up the identification of novel targeted curcumin-based drugs to treat cancer.

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The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis

Cited by 25 publications

References 49 publications

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors

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