The Efficacy of Acetaminophen–Caffeine Compared to Ibuprofen in the Control of Postoperative Pain After Periodontal Surgery: A Crossover Pilot Study

Rashwan, Weam

doi:10.1902/jop.2009.080637

Cited by 26 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies have investigated the effect of different NSAIDs to control postoperative pain after open‐flap surgery with generally favorable results . However, to the author's knowledge there was no available study on the use of topical NSAIDs at donor site wound model after periodontal plastic surgery.…”

Section: Discussionmentioning

confidence: 99%

Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo‐controlled study

İşler

Eraydin

Akkale

et al. 2018

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo‐controlled study

İşler

Eraydin

Akkale

et al. 2018

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

“…On the other hand, caffeine can increase gastrointestinal movements and increase absorption of other analgesics. Therefore, presence of caffeine along with other analgesics is recommended to increase their efficacy (13). Mehrvarz et al compared the analgesic effects of naproxen, Novafen and tramadol in preventing pain after radicular surgeries with those of a placebo and reported that all the three medications were effective (14).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Analgesic Effects of Novafen and Ibuprofen after Periodontal Surgeries

Babaloo

Rahbar

Ghasemi

et al. 2017

ABCMed

View full text Add to dashboard Cite

Introduction: Management of pain after dental procedures is one of the most important issues for dentists. Non-steroidal antiinflammatory agents, such as ibuprofen, are one of the most commonly used medications to relieve pain. Recently a new medication, Novafen, has been introduced into the Iranian pharmaceutical market, which is a combination of ibuprofen, acetaminophen and caffeine. Considering the importance of management of pain after periodontal surgeries and a paucity of studies in this respect, the present study was undertaken to compare the analgesic efficacy of Novafen and ibuprofen in alleviating pain after periodontal surgeries. Materials and methods: In the present controlled randomized clinical trial, 30 systemically healthy subjects with moderate to severe generalized chronic periodontitis, who were candidates for flap surgeries were evaluated in two groups with 30 areas in each group (two areas in each patient). After the periodontal surgical procedures, the subjects in group 1 received Novafen capsules (containing 325 mg of acetaminophen, 200 mg of ibuprofen and 40 mg of caffeine) and the subjects in group 2 received ibuprofen (400 mg). The medications were selected from one pharmaceutical company and the patients only used the medications they received. The severity of pain was determined and compared at 3-minute, 1-hour and 3-hour intervals using VAS and 1, 2 and 3 days postoperatively using VRS. Results: Severity of pain at 30-minute interval in the Novafen group was significantly less than that in the ibuprofen group, with no significant differences at 1- and 3-hour intervals. However, VRS revealed significantly less pain 1, 2 and 3 days postoperatively in the Novafen group compared to the ibuprofen group. Conclusion: Based on the results of the present study, it can be concluded than Novafen can be more effective after periodontal surgeries in alleviating pain. However, its pain control capacity was similar to that of ibuprofen during the early postoperative hours, with better performance 1‒3 days postoperatively.Key words: Novafen; ibuprofen; pain relief; periodontal surgery; Analgesia;

show abstract

“…In an experimental pain model, paracetamol (1,000 mg) when combined with caffeine (130 mg) had a sustained antinociception‐enhancing effect [30]. Moreover, the combination of paracetamol and caffeine has been shown to be as efficacious as ibuprofen after periodontal surgery [31] and naproxen sodium in tension‐type headache [32]. However, few studies have evaluated the efficacy of a caffeine‐analgesic combination vs the same analgesic alone.…”

Section: Introductionmentioning

confidence: 99%

A Risk-Benefit Assessment of Paracetamol (Acetaminophen) Combined with Caffeine

Palmer¹,

Graham²,

Williams³

et al. 2010

Pain Med

View full text Add to dashboard Cite

show abstract

The Efficacy of Acetaminophen–Caffeine Compared to Ibuprofen in the Control of Postoperative Pain After Periodontal Surgery: A Crossover Pilot Study

Abstract: Acetaminophen, 500 mg, with caffeine, 30 mg, can be used efficiently in controlling postoperative pain after open flap debridement, especially in patients with gastric ulcers or bleeding tendency because acetaminophen is less hazardous than ibuprofen.

Cited by 26 publications

References 38 publications

Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo‐controlled study

Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo‐controlled study

Comparison of Analgesic Effects of Novafen and Ibuprofen after Periodontal Surgeries

A Risk-Benefit Assessment of Paracetamol (Acetaminophen) Combined with Caffeine

Contact Info

Product

Resources

About