The efficacy for unresectable hepatocellular carcinoma may be improved by transcatheter arterial chemoembolization in combination with a traditional Chinese herbal medicine formula

Yu, Yang; Lang, Qing-bo; Chen, Zhe; Li, Bai; Yu, Chaoqin; Zhu, Dong‐Ya; Zhai, Xiaofeng; Ling, Changquan

doi:10.1002/cncr.24567

Cited by 43 publications

(37 citation statements)

References 53 publications

(33 reference statements)

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“…In China, traditional Chinese medicine has been widely used in all aspects of liver cancer, including surgery, interventional and targeted therapy, even as a single treatment for advanced liver cancer, and has been confirmed to effectively control cancer progression, improve quality of life and prolong survival times, to some extent, in liver cancer patients (7)(8)(9)(10). Liver Yin deficiency is one of the common syndromes included in or accompanying liver cancer (11,12).…”

Section: Introductionmentioning

confidence: 99%

Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells

Shen

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Liver cancer ranks as the fifth most prevalent malignancy of all cancers worldwide. According to the principles of traditional Chinese medicine, liver Yin deficiency is a common clinical syndrome of liver cancer, and tonifying liver Yin is a common treatment method for liver cancer. However, no hepatocarcinoma-specific liver Yin tonifying formula has yet been established. In the present study, we established a liver cancer-specific combination of herbs, which we term liver Yin tonifying formula (LYTF). We found that LYTF inhibits the proliferation of Bel-7402 cells in a dose-and time-dependent manner. LYTF induces apoptosis in Bel-7402 cells, which is accompanied by activation of caspases-8, -9 and -3. Pan-caspase blocking completely abrogates LYTF-induced apoptosis and partially abrogates LYTF-induced proliferation inhibition. LYTF also induces cell senescence, as indicated by a large and flattened morphology, senescence-activated β-galactosidasepositive staining and G0/G1 cell cycle arrest, accompanied by the up-regulation of p16 and p21 and the down-regulation of retinoblastoma protein phosphorylation. These findings suggest that LYTF is effective in inhibiting the growth and survival of hepatocarcinoma cells through the induction of apoptosis and cell senescence. Our study also provides insight into traditional Chinese medicine methods used for the treatment of liver cancer.

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Section: Introductionmentioning

confidence: 99%

Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells

Shen

et al. 2011

Experimental and Therapeutic Medicine

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“…TCM has been used to improve efficacy of TACE. JDF granule preparation, a traditional Chinese herbal formula, combined with TACE may prolong survival time in patients with unresectable hepatocellular carcinoma [75] . Shentao Ruangan pill based herbal therapy in combination with TACE could prolong survival time in patients with middleadvanced stage liver cancer [76] .…”

Section: Tcm In Combination With Tacementioning

confidence: 99%

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Wang

2015

WJH

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and other TCM syndromes (Zheng). Modern treatments such as surgery, transarterial chemoembolization (TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma. AbstractTraditional Chinese medicine (TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency REVIEWSubmit a

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“…Secondly, TCM can significantly inhibit liver tumor growth and angiogenesis [76,77], while restraining the progress of liver cancer [78,79]. Thirdly, TCM can promote the immune response and improve the QOL of the patient by protecting life functions [74,80], and then prolong survival of patients and improve the prognosis of patients with unrespectable HCC [70,[81][82][83]. Thus, the local application of TCM combined with systemic therapy might be an effective measure of non-operational therapy for treating HCC [11,84].…”

Section: Combination Of Tcm and Interventional Therapy For Treatment mentioning

confidence: 99%

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

Feng¹,

Zhu²,

Hu³

et al. 2017

Cancer Rep Rev

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide with a high mortality, and still there are only few effective methods to treat it. To this end, alternative medicines from traditional Chinese medicine (TCM) are being investigated for their ability to eliminate the tumor or halt its progression. A large number of studies have shown that TCM can be an effective approach to treat the HCC in clinical trials when used alone or in combination with other therapies. Thus, TCM has made significant progress, and has begun to gain worldwide popularity for promoting healthcare and HCC treatment. Because of this progress, periodic summaries are needed to facilitate further research for the use of TCM to treat HCC. This paper provides a comprehensive summary of this work with regard to the following aspects: herbalist views on the etiology and therapeutic principles for treatment of HCC, treating HCC by TCM alone, treating HCC with TCM in combination with resection, chemotherapy, radiotherapy and interventional therapy, and other therapies. Additionally, the current main problems and future application prospects for treatment of HCC by TCM described, which could provide scientific guidance for clinician as well as references for the treatment of other cancers.

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The efficacy for unresectable hepatocellular carcinoma may be improved by transcatheter arterial chemoembolization in combination with a traditional Chinese herbal medicine formula

Cited by 43 publications

References 53 publications

Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells

Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

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