The efficacy and tolerability of 5‐aminolevulinic acid 5% thermosetting gel photodynamic therapy (PDT) in the treatment of mild‐to‐moderate acne vulgaris. A two‐center, prospective assessor‐blinded, proof‐of‐concept study

Abstract

This proof-of-concept study supports the efficacy of 5% ALA thermosetting gel red-light PDT in inflammatory acne of the face with a relevant clinical improvement of inflammatory lesions with a very good tolerability profile. Clinical improvement was maintained in the medium term (Trial Registration Number: ISRCTN66066651).

Fluorescence Diagnostics and Photodynamic Therapy In Cancer

“…35 patients were examined. The results of the study confirmed the effectiveness of this method despite the reduction of ALA concentration (97). Figure 11)…”

An overview of treatment options for mild‐to‐moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines

“…Depending on the wavelength, lasers act at different levels 32,33 ; in particular the infrared rays act on the sebaceous gland causing a thermal coagulation and consequently a reduced sebum production. 30 These include herbium glass and YAG laser. Other lasers that are used in acne are the diode laser and the pulse dye.…”

“…Its efficacy in the treatment of acne has been shown by several studies 28,29 . A two‐center, prospective assessor‐blinded, proof‐of‐concept study assessed the effectiveness of PDT with red light in combination with 5% gel aminolevulinic acid in the treatment of the inflammatory component of mild‐to‐moderate acne 30 . Thirty‐five patients with moderate acne were enrolled and clinical status was assessed considering Global Acne Grade System (GAG) at baseline and after three sessions of PDT (each of 15 minutes) with a statistically significant reduction of GAG score ( P = .0001) 30 …”

“…30 Thirty-five patients with moderate acne were enrolled and clinical status was assessed considering Global Acne Grade System (GAG) at baseline and after three sessions of PDT (each of 15 minutes) with a statistically significant reduction of GAG score (P = .0001). 30…”

Aminolevulinic acid photodynamic therapy for folliculitis decalvans: A case report

“…According to PDT in the treatment of mild‐to‐moderate acne vulgaris, 2 a 5.0% ALA solution was freshly prepared with ALA powder (Shanghai Fudan‐Zhangjiang BioPharmaceutical, Shanghai, China) in a dark room. Before the therapy was started, the patient's scalp was cleaned with iodine, and we used sterile disposable needles to remove the crust of the lesions.…”