The Efficacy and Safety of Hyaluronic Acid Microinjection for Skin Rejuvenation in Vietnam

Trọng, Hào Nguyễn; Phuong, Thao Vu Thi; Nguyen, Thuong Van; Thai, Ha Vu; Huu, Nghi Dinh; Nguyet, Minh Vu; Hau, Khang Tran; Gandolfi, Marco; Satolli, Francesca; Feliciani, Claudio; Tirant, Michael; Vojvodić, Aleksandra; Lotti, Torello

doi:10.3889/oamjms.2019.059

Cited by 5 publications

(17 citation statements)

References 6 publications

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“…HA filler injections used to enhance lip fullness indicated that HA is safe and effective (17). Consistent with these results, 93% of participants in the HA face microinjection procedure felt satisfied with no remarkable adverse effects (18). HA dermal fillers have evolved in recent years, and some complications have been associated with their use.…”

Section: Introductionsupporting

confidence: 53%

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

2023

JPTCP

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Background: The use of non-invasive cosmetic procedures such as Botulinum toxin and hyaluronic acid filler (HA) are commonly used in cosmetic and therapeutic. However, BOTOX therapy is generally considered safe and without significant adverse effects. However, these treatments' impacts must be understood and investigated thoroughly. The objective of this prospective study was to evaluate the impact of using injections of hyaluronic acid filler (HA) and BOTOX on some human biochemical parameters, CBC, and inflammatory markers. Methods: Eighty-five subjects who have undergone BOTOX and/or HA injections were recruited. Samples of study and control groups were collected into EDTA for CBC and serum tubes for the analysis of the rest of the parameters. Results: Our results revealed that using BOTOX and HA filler has no significant effect on ALT, AST, GGT, and CK-MB levels (p-value > 0.05). While there was a decrease in ALP level in subjects injected with both BOTOX and HA filler. Moreover, we discovered that two of our study groups had significantly higher serum LDH levels than the control group. CRP, TNF-α, and IL-17 were elevated in the study group compared with the control group. However, this difference was statistically insignificant (p-value > 0.05). Conclusion: Accordingly, using BOTOX and HA filler may result in mild changes in clinical laboratory tests. Future investigations are now necessary to highlight the influence of these cosmetic procedures on various clinical laboratory parameters.

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Section: Introductionsupporting

confidence: 53%

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

2023

JPTCP

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“…A high level of satisfaction with the appearance of the facial skin after tear trough and temporal fossa augmentation was noted by Tung et al, and Berguiga et al 32,33 Jegasothy et al, 34 also reported beneficial effects (wrinkle depth reduction, improved skin hydration, firmness and elasticity) of low molecular nano-hyaluronic acid injections. Positive changes in the appearance of the facial skin after HA treatment (improved firmness and pigmentation) were observed by Landi et al 35 Trong et al 36 also documented improved skin elasticity and wrinkle depth reduction, while Baspeyras et al, 37 observed significant improvement in skin hydration, firmness and viscoelasticity after HA microinjection treatment. A statistically significantly improved radiance, pigmentation and hydration were observed by Sparavigna et al, 38 in the process of treating skin with symptoms of ageing and photoaging.…”

Section: Discussionmentioning

confidence: 84%

<p>Subjective Evaluation of the Results of Injectable Hyaluronic Acid Fillers for the Face</p>

Matecka¹,

Lelonkiewicz²,

Pieczyńska³

et al. 2020

CIA

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Background: Skin ageing is a physiological process, progressive and irreversible. Hyaluronic acid injection treatments are used to correct the signs of skin ageing. Material and Methods: Hyaluronic acid was implanted in the area of the cheek and the forehead aesthetic units in 57 women, aged 35−55 years. Apart from the clinical observation, self-assessment of the therapeutic results was conducted. The "My skin" questionnaire was used for subjective evaluation of the treatment results. Results: Mean wrinkle score in the pre-menopausal group changed after the treatment, from 3.2±0.6 to 1.1±0.3 and from 3.2±0.6 to 0.8±0.6 for the forehead and the cheek esthetic units, respectively. In the post-menopausal group, the score decreased from 3.8±0.4 to 1.7± 0.7 and from 3.2±0.617 to 0.8± 0.6 for the forehead and the cheek esthetic units, respectively. The changes were age-dependent. Improved appearance of the facial skinhigher satisfaction with skin tone and scentwas reported after hyaluronic acid injections. Higher subjective perception of improvement corresponded to older age, irrespectively of the menopausal status. Correlations between age and the effect of the treatment on maintaining proper skin hydration as well as between improved appearance of the forehead area and feelings of autonomy and well-being were found. Conclusion: Hyaluronic acid injections significantly improved the subjective perception and overall assessment of the scent and appearance of the facial skin.

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“…10 Biophysical measurements and colorimetry showed improvement in both superficial and deep skin hydration, erythema, PH of skin, and sebum produc tion. [1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail.…”

Section: Treatment Characteristics and Injection Techniquesmentioning

confidence: 91%

“…[1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail. Although electron microscopy showed neocollagenesis of smaller caliber collagen fibers, but the result was not statistically significant.…”

Section: Treatment Characteristics and Injection Techniquesmentioning

confidence: 91%

“…Treatment sessions for non-cross-linked HA were between 1 and 6 at weekly-to-bimonthly interval, and for cross-linked HA were Fourteen studies used mesotherapy compounds for face rejuvenation with contradictory results. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Ten studies revealed significant improvement in clinical features, biophysical measurements, and histological and ultrasound evaluation. Results of these studies confirmed efficacy of non-cross-linked HA on fine lines for both static and dynamic rhytids.…”

Section: Treatment Characteristics and Injection Techniquesmentioning

confidence: 99%

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Employing hyaluronic acid‐based mesotherapy for facial rejuvenation

Iranmanesh

Khalili

Mohammadi

et al. 2022

J of Cosmetic Dermatology

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Background Mesotherapy is a method of treatment in which biocompatible substances are injected in small aliquots into different levels of skin. This technique can be used for facial rejuvenation. Aim To comprehensively evaluate efficacy of different hyaluronic acid (HA) materials for skin rejuvenation, and discuss longevity of these products, potential adverse effects, and different injection techniques. Material and Methods We searched Pubmed, Scopus, Web of science, Google Scholar, Embase, Cochrane Library, and Science direct until April of 2022. Thirty‐four articles were selected including 23 articles about non‐cross‐linked HA and 11 articles about cross‐linked HA. Results Eleven and five different non‐cross‐linked HA and cross‐linked HA materials were utilized, respectively. Treatment sessions for non‐cross‐linked HA were between 1 and 6 at weekly‐to‐bimonthly interval, and for cross‐linked HA were 1–3 at 4–36 weeks apart. In most of the studies, serial micropuncture technique with 23–32 gauge needles was used for injection. Other injection techniques were Nappage (picotage), depot and micro‐linear. Conclusion Mesotherapy with HA‐based fillers is a favorable method for restoring youthful appearance, rejuvenation, and revitalization of skin. Proper selection and precise placement of HA in desired level of dermis is an essential key to optimize improvement and minimize side effects including skin irregularities and Tyndall effect. Adjuvant therapy with additional rejuvenation procedures to enhance esthetic results is required especially in elderly individuals with severe photodamaged skin. Moreover, preservation of esthetic results requires maintenance therapy every few months.

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The Efficacy and Safety of Hyaluronic Acid Microinjection for Skin Rejuvenation in Vietnam

Cited by 5 publications

References 6 publications

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

<p>Subjective Evaluation of the Results of Injectable Hyaluronic Acid Fillers for the Face</p>

Employing hyaluronic acid‐based mesotherapy for facial rejuvenation

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